Glycaemic burden disrupts innate immunity in TB by modulating CD206 expression and macrophage antimicrobial responses [0.03%]
高血糖通过调节CD206表达和巨噬细胞抗菌反应干扰结核病的固有免疫功能
Alisha Arora,Sudhasini Panda,Kalpana Luthra et al.
Alisha Arora et al.
Tuberculosis (TB) and diabetes mellitus (DM) represent a growing dual global health burden, with chronic hyperglycaemia recognized as a major modifier of host immunity against Mycobacterium tuberculosis (Mtb). Macrophages, central to pathog...
Dynamic kinetics and clinical utility of a ddPCR-based 3-gene host transcriptional signature for monitoring tuberculosis treatment response: a prospective multicenter study [0.03%]
动态定量3基因宿主转录特征监测结核病治疗反应的临床效用及动力学研究：一项前瞻性多中心研究
Qian Qiu,Bo Liu,Wei Zhang et al.
Qian Qiu et al.
Drug resistance in tuberculous meningitis: A laboratory-based observational study from Northern India's tertiary care referral centre [0.03%]
印度北部三级护理转诊中心结核性脑膜炎耐药性实验室观察研究
Kalpana Kuntal,Manu Singh,Parul Jain et al.
Kalpana Kuntal et al.
Tuberculous meningitis (TBM) is the most severe form of tuberculosis and is associated with high mortality and long-term neurological disability. Detection of drug resistance remains challenging because cerebrospinal fluid (CSF) specimens a...
Multiparametric flow cytometry immune profiling of pulmonary and extra-pulmonary tuberculosis reveals distinct blood-based biomarker signatures [0.03%]
多参数流式细胞仪免疫谱分析肺和肺外结核患者并发现基于血液的生物标志物特征签名
Kalaiarasan Ellappan,Noyal Mariya Joseph,Prakash Babu Narasimhan et al.
Kalaiarasan Ellappan et al.
This study investigated immune cell distributions, cell-specific immune markers, and selected biomarker targets in pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) using multiparametric flow cytometry (MFC). Whole blood w...
FadR subfamily of transcriptional regulators are dispensable for the pathogenesis of Mycobacterium tuberculosis [0.03%]
FadR亚家族转录调控因子对结核分枝杆菌毒力并非必不可少
Saurabh Chugh,Bhupinder Singh,Neeraj Kumar Chauhan et al.
Saurabh Chugh et al.
A diverse set of transcriptional regulators (TRs) enables Mycobacterium tuberculosis (M. tuberculosis) to reprogram its gene expression profiles to adapt and counteract the challenges imposed by the host during infection. FadR subfamily TRs...
Host-derived proteomic biomarkers for discriminating the tuberculosis disease spectrum in a Brazilian cohort [0.03%]
基于巴西队列的区分结核病谱系的宿主衍生蛋白组生物标志物
Matheus Rogerio Almeida,Anouk van Hooij,Louise Pierneef et al.
Matheus Rogerio Almeida et al.
Despite significant efforts to improve diagnostics, tuberculosis (TB) diagnosis still relies on clinical and laboratory methods limited by cost, expertise, and time. Early diagnosis is essential for effective management of pulmonary TB (PTB...
Association between gut microbiota and white matter microstructural damage in tuberculous meningitis patients [0.03%]
结核性脑膜炎患者肠道菌群与白质微结构损伤的关系
Zexuan Xu,Yanpin Liu,Yilin Wang et al.
Zexuan Xu et al.
Background: Tuberculous meningitis (TBM), the most severe form of tuberculosis, may involve the gut-brain axis. This study investigated the link between TBM, brain white matter integrity measured by diffusion tensor imagi...
Context-dependent transcriptional and epigenetic reprogramming shapes neutrophil antimicrobial and immunoregulatory functions in tuberculosis [0.03%]
转录和表观遗传重编程在白细胞中的作用：影响肺结核中白细胞的抗菌和免疫调节功能
Cicero José Luíz Dos Ramos Almeida,Ricardo Cardoso Castro,Priscilla Mariane Cardoso-Silva et al.
Cicero José Luíz Dos Ramos Almeida et al.
Inflammatory microenvironments regulate immune cell differentiation, activation, and programming. Although traditionally considered terminally differentiated effectors, neutrophils can acquire distinct functional states in response to envir...
Discovery and identification of a handwritten laboratory notebook by Albert Calmette and Camille Guérin describing experimental studies and development of the BCG vaccine for tuberculosis at the Institut Pasteur [0.03%]
卡尔梅特和盖林关于卡介苗实验研究与开发的笔记手稿的发现与鉴定：巴斯德研究院档案中的结核病疫苗故事
Lou Migliorini,David A Schwartz
Lou Migliorini
Background: The Bacille Calmette-Guérin (BCG) vaccine against tuberculosis is the most widespread vaccine in the world. Discovered by French investigators Albert Calmette and Camille Guérin at the Pasteur Institute, it ...
Delineating the potential of bioenergetics in drug discovery against Mycobacteriumabscessus [0.03%]
划定生物能学在分枝杆菌药物发现中的潜力
Swati Meshram,Puja Kumari Agnivesh,Nitin Pal Kalia
Swati Meshram
Pulmonary and skin infections caused by Mycobacterium abscessus, a rapidly growing non-tuberculous mycobacterium (NTM), are becoming increasingly prevalent worldwide. Managing these infections is particularly challenging due to the bacteriu...