Bone microarchitecture and strength in men with prostate cancer with and without prevalent vertebral fractures at the initiation of androgen deprivation therapy [0.03%]
前列腺癌伴或不伴有椎骨骨折的男性在开始雄激素剥夺治疗时的骨微结构和强度
Marsha M van Oostwaard,Melissa S A M Bevers,Johanna H M Driessen et al.
Marsha M van Oostwaard et al.
Androgen deprivation therapy (ADT) in prostate cancer (PCa) is associated with an increased fracture risk. However, studies on the prevalence of low areal bone mineral density (aBMD) and vertebral fractures (VFs) at the initiation of ADT an...
Integrating single-cell and bulk transcriptome analysis of fibroblast growth factor 23 (FGF23)-producing mesenchymal tumors reveals molecular basis of its secretory phenotype [0.03%]
整合单细胞和批量转录组分析成纤维细胞生长因子23（FGF23）产生的间充质肿瘤，揭示其分泌表型的分子基础
Sofia A Gronskaia,Ruslan M Deviatiiarov,Vladimir P Chekhonin et al.
Sofia A Gronskaia et al.
Tumor-induced osteomalacia (TIO) is a rare disorder caused by a phosphaturic mesenchymal tumor (PMT) secreting fibroblast growth factor 23 (FGF23). The aim of this study was to analyze PMTs for their transcriptomic characteristics. We perfo...
Childhood obesity influences mid-to-late life bone health through shared genetic architecture [0.03%]
儿童肥胖通过共同的遗传结构影响中年至晚期骨骼健康
Maoyao Xia,Yang Qu,Bowen Lei et al.
Maoyao Xia et al.
Background: Despite higher body mass index (BMI) in adulthood being widely acknowledged as protective for bone mineral density (BMD), the effect of childhood BMI on adult BMD remains inconclusive. This study aims to eluci...
Involvement of impaired phosphate production and aberrant extracellular ATP signaling in the pathogenesis of hypophosphatasia: Analysis of ALPL-Knockout human iPS cell models [0.03%]
磷生成障碍和异常的细胞外ATP信号在低磷血症发病机制中的作用：ALPL敲除人类IPS细胞模型分析
Miwa Yamazaki,Ayu Ueta,Tatsuro Nakanishi et al.
Miwa Yamazaki et al.
Hypophosphatasia (HPP) is caused by inactivating variants of ALPL, the gene encoding tissue non-specific alkaline phosphatase (TNSALP). In order to deepen our understanding of the pathogenic mechanisms of HPP, we herein generated ALPL-knock...
Understanding the genetic basis of medication-related osteonecrosis of the jaw: A systematic review [0.03%]
理解与药物相关的颌骨坏死的遗传基础：系统性综述
Sonya Radi,Deborah Sarah Jans,Catalina Moreno-Rabié et al.
Sonya Radi et al.
Medication-related osteonecrosis of the jaw (MRONJ) is an adverse event often associated with the use of antiresorptive drugs. This systematic review aims to identify genes and their polymorphisms associated with the risk of developing MRON...
The microstructure of metastatic bone lesions suggests tumor mediated alterations in bone mineralization [0.03%]
骨转移病灶的微细结构提示肿瘤介导的骨矿化改变
Hanwen Fan,Zhan Xu,Carla Berrospe Rodriguez et al.
Hanwen Fan et al.
Breast, prostate and lung cancer cells frequently metastasize to bone, leading to disruption of the bone microstructure. This study utilized mechanical testing with micro-CT imaging, digital volume correlation (DVC), and atomic force micros...
The adiponectin agonist AdipoRon accelerates osteoporosis development in two different models and modulates adipocyte differentiation [0.03%]
脂肪细胞增生调节剂AdipoRon加速两种不同模型的骨质疏松症的发展并调节脂肪细胞分化
Julia Halper,Sarah Nicolas,Federica Gilardi et al.
Julia Halper et al.
Osteoporosis is an increasing concern in the aging population worldwide, culminating in increased economic concerns and diminished quality of life. Similarly, disturbances of lipid metabolism and adipocytes accumulate more and more in weste...
Impact of baseline PINP on the BMD increase with romosozumab, teriparatide, and denosumab in treatment-naïve primary osteoporosis: A retrospective cohort study [0.03%]
基线PINP对初治原发性骨质疏松患者使用Romosozumab、特立帕肽及地舒单抗治疗后BMD增幅的影响：回顾性队列研究
Yuki Etani,Takaaki Noguchi,Toshitaka Yukishima et al.
Yuki Etani et al.
Purpose: To investigate the impact of baseline total N-terminal propeptide of procollagen (PINP) levels on increases in bone mineral density (BMD) after treatment with romosozumab (ROMO), teriparatide (TPTD), and denosuma...
Plasma proteomic markers of pain and emotional dysfunction in fibrous dysplasia/McCune-Albright syndrome [0.03%]
纤维性骨发育不良/麦卡恩-阿尔布赖特综合征的血浆蛋白标记物疼痛和情感障碍
Camryn Berry,Evan E Hsu,Courtney LeSon et al.
Camryn Berry et al.
Pain in Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) remains poorly understood and inadequately managed due to uncertainties regarding clinical or biological drivers. This cross-sectional pilot study aimed to use plasma proteomics to...
The role of probiotics in modulating RANKL in osteoporosis: A systematic review of animal interventional studies and RCTs [0.03%]
益生菌通过调节骨代谢中的RANKL信号通路防治骨质疏松症的机制：系统综述及动物实验和随机对照试验的元分析
Fatemeh Hamedi-Kalajahi,Mohammad Alizadeh,Sorayya Kheirouri
Fatemeh Hamedi-Kalajahi
Background: Osteoporosis is a major global health concern characterized by reduced bone mass and structural deterioration. The RANK/RANKL/OPG signaling pathway plays a pivotal role in bone remodeling, particularly in oste...