Local delivery of rhBMP-2 affects systemic metabolic response during healing of critically-sized segmental defects in a rat model [0.03%]
局部应用rhBMP-2对大鼠 critical size 缺损愈合过程中全身代谢反应的影响研究
Elisabeth M Schwiebert,Lia K Strait,Samuel G Moore et al.
Elisabeth M Schwiebert et al.
Understanding the biological mechanisms behind fracture nonunions and their treatments remains incomplete. Since these mechanisms are linked to phenotypic expression, studying the longitudinal metabolic profile of bone regeneration has emer...
Subtype-specific bone mineralization defects and early treatment amelioration in murine models of autosomal recessive osteopetrosis revealed by Raman spectroscopy [0.03%]
拉曼光谱揭示的自体显性遗传性大理石骨病小鼠模型的亚型特异性骨矿化缺陷和早期治疗改善作用
Marco Ventura,Victor Alcolea-Rodriguez,Chiara Agrimi et al.
Marco Ventura et al.
Autosomal recessive osteopetrosis is a rare genetic disorder caused by impaired osteoclast function, leading to excessive bone mass, defective remodeling, and fragility fractures. While bone density alterations are well recognized, composit...
Validation of 3D-DXA-derived proximal femur measurements against QCT across international clinical cohorts [0.03%]
基于国际临床队列的三维数字化射线透视骨密度仪测量股骨近端参数与定量计算机断层扫描结果之间的对比验证研究
Marta I Bracco,Dennis M Black,Teruki Sone et al.
Marta I Bracco et al.
Three-dimensional dual-energy X-ray absorptiometry (3D-DXA) reconstructs proximal femur models from standard scans to estimate cortical and trabecular bone parameters. The aim of this study was to evaluate 3D-DXA against quantitative comput...
Lrsam1 deficiency suppresses osteoclastogenesis and attenuates bone loss through the JNK2-NFATc1 axis [0.03%]
Lrsam1缺陷通过JNK2-NFATc1轴抑制破骨细胞生成并减轻骨丢失
Xiaohe Wang,Gang Yu,Chao Fang et al.
Xiaohe Wang et al.
Excessive osteoclast-mediated bone resorption is a major contributor to osteoporosis and other osteolytic diseases. Here, we investigated the role of the E3 ubiquitin ligase Lrsam1 in osteoclastogenesis and bone metabolism using myeloid-spe...
Development of the Fibrodysplasia Ossificans Progressiva FLare EXperience Revised (FOP-FLEX-R©) Questionnaire: A patient-reported outcome measure [0.03%]
纤维发育不良进行性骨化症（FOP）病发体验问卷修订版（FOP-FLEX-R版）的开发：患者报告的结果测量指标
Robert J Pignolo,Edward C Hsiao,Mona Al Mukaddam et al.
Robert J Pignolo et al.
Background: Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare, genetic disorder mainly characterized by progressive heterotopic ossification (HO). Flare-ups in FOP, involving soft tissue swelling, pain, warmth,...
"Weekend warrior" physical activity pattern and risk of low bone mass and related fractures: Results from two nationwide population-based surveys [0.03%]
周末运动与低骨量及骨折风险的关联：全国两份基于人口的调查结果
Yuan-Wei Zhang,Peng Wei,Li-Song Feng et al.
Yuan-Wei Zhang et al.
Background: Physical activity (PA) is crucial for maintaining bone mass. However, it remains unclear whether the "weekend warrior" (WW) pattern, namely condensing moderate-to-vigorous physical activity (MVPA) into 1 or 2 ...
EP4 agonist KMN-159 induces osteogenesis in rodent and porcine dental models [0.03%]
EP4激动剂KMN-159在啮齿类和猪牙模型中诱导成骨作用
Thomas A Owen,Phillip Rzeczycki,Natalia Da Ponte Leguizamon et al.
Thomas A Owen et al.
The selective EP4 receptor (PTGER4) agonist KMN-159 stimulates osteoblast function and may support applications in dental bone tissue regeneration and tissue engineering. The goal of this study was to further validate stimulation of osteoge...
Morphological micro-computed tomography assessment of cleaned freeze-dried compacted cancellous bone allografts [0.03%]
清洁冷冻干燥的松质骨同种异体移植骨的微结构评估
D Putzer,C Spiegel,J Pallua et al.
D Putzer et al.
Bone grafting is widely used in reconstructive surgery, with allogeneic grafts serving as an important alternative to autologous bone. The influence of compaction on the microarchitecture of cleaned cancellous bone allografts remains insuff...
Childhood cancer survivors with premature ovarian insufficiency have low bone mineral density at long term follow-up [0.03%]
长期随访发现儿童期癌症幸存者卵巢功能不足患者骨密度低
Axel Netterlid,Helena Mörse,Kristina E Åkesson et al.
Axel Netterlid et al.
Background: Childhood cancer survivors (CCS) are reported to have decreased bone mineral density (BMD). Purpose: Is premature ovarian i...
TGF-β1-regulation of bone formation via the miR-3064-3p/HDAC4/Runx2 axis: In vitro and in vivo studies [0.03%]
转化生长因子β1通过miR-3064-3p/组蛋白去乙酰化酶4/Runt相关基因2轴调节骨形成的体内和体外研究
Iyyappan Saranya,Dilipkumar Preetha,Sasi Nivruthi et al.
Iyyappan Saranya et al.
Transforming growth factor-beta1 (TGF-β1) regulates bone formation through Runx2, a bone transcription factor, and Runx2 activity is regulated by several coactivators and corepressors. Histone deacetylase 4 (HDAC4) functions as a transcrip...