Inosine ameliorated bone destruction and inflammation in rheumatoid arthritis via inhibiting osteclastogenesis and synovial fibroblasts activation [0.03%]
次黄嘌呤改善类风湿性关节炎骨破坏和炎症的机制研究
Xia-Nan Wu,Ke Dong,Li Liu et al.
Xia-Nan Wu et al.
This study aim to investigate the effects of inosine on rheumatoid arthritis (RA) disease and explore the potential mechanism. Collagen-Induced Arthritis (CIA) rats were used to investigate the effects of inosine on bone destruction and inf...
Association of metabolic score for visceral fat with fragility fracture risk: The combined and mediating roles of arterial stiffness [0.03%]
内脏脂肪代谢积分与骨折风险的相关性：动脉僵硬的联合及中介作用
Lu Guo,Shaoxuan Wei,Qian Liu et al.
Lu Guo et al.
Objectives: To investigate the combined effect of the metabolic score for visceral fat (METS-VF) and arterial stiffness on fragility fractures, and to further examine whether arterial stiffness, measured by brachial-ankle...
ED-71 alleviates OVX-induced osteoporosis by inhibiting macrophage senescence through SIRT1/PGC-1α pathway: A potential therapeutic approach [0.03%]
ED-71通过SIRT1/PGC-1α途径抑制巨噬细胞衰老从而缓解卵巢切除诱导的骨质疏松症：一种潜在的治疗方法
Yaqiu Fu,Lingxiao Meng,Minglei Zhang et al.
Yaqiu Fu et al.
Postmenopausal osteoporosis (PMOP) is a prevalent condition among postmenopausal women, closely linked to estrogen deficiency, aging, and oxidative stress. Cellular senescence, through mechanisms such as the senescence-associated secretory ...
Pain intensity in patients with genetic metabolic bone diseases: an observational study [0.03%]
遗传性代谢骨病患者的疼痛强度：一项观察性研究
Mattia Morri,Morena Tremosini,Cristiana Forni et al.
Mattia Morri et al.
Objective: The aim of this study was to describe the intensity of the pain in patients with genetic metabolic bone disease and to identify possible risk factors. ...
AI-supported opportunistic detection of vertebral fractures on routine CT scans: Diagnostic performance and clinical relevance [0.03%]
基于人工智能的常规CT扫描中机会性椎体骨折检测：诊断性能和临床意义
Martina Behanova,Anton Sokhan,Judith Haschka et al.
Martina Behanova et al.
Background: Vertebral fractures (VFs) are among the most common osteoporotic fractures, yet they are frequently underdiagnosed and left untreated. The use of an artificial intelligence (AI) tool may support improved detec...
Influence of pressure on mandibular angiosomes: What implications for decellularization? [0.03%]
压力对下颌血管区域的影响：对于脱细胞有什么启示？
Corentin Serra,Romain Monchaux,Benjamin Salmon et al.
Corentin Serra et al.
The vascularization of bone still holds several unknowns, crucial to future developments in reconstructive surgery: both for bone transplantation and decellularized allograft. This study introduces a novel method to analyze pressure-depende...
Enhanced fracture repair in p21-/- mice is mediated through increased callus mineralization [0.03%]
p21缺陷小鼠骨折修复增强是由矿化增加介导的
Alexandra Olsen,Priyatha Premnath,Scott Brunet et al.
Alexandra Olsen et al.
Fracture healing is a complex, multi-phase process involving mesenchymal progenitor cell (MPC) recruitment, chondrogenesis, osteogenesis and bone remodelling. The cyclin-dependent kinase inhibitor p21 is known to regulate cell cycle progres...
CTLA4-Ig sustains osteogenic potential and inhibits osteoclastogenesis in Staphylococcus aureus osteomyelitis [0.03%]
CTLA4-Ig维持金黄色葡萄球菌骨髓炎中的成骨潜能并抑制破骨细胞生成
Rongjie Lin,Yiqing Huang,Zhenbin Chen et al.
Rongjie Lin et al.
Osteomyelitis (OM) is a severe bone-destructive disease characterized by infection and inflammation. Transcriptomic analysis of datasets GSE18043 and GSE30119 identified CTLA4 as a key regulator associated with immune modulation and osteoge...
Accelerometer-derived daily impact score is positively associated with bone strength accrual during adolescence [0.03%]
基于加速计的每日冲击评分与青春期骨强度积累呈正相关
Christina J Alexander,Heather M Macdonald,Heather A McKay et al.
Christina J Alexander et al.
Bone adapts to its loading environment throughout the lifespan, with rapid gains during adolescence. Accelerometers are commonly used to measure physical activity (PA) and examine its associations with bone outcomes; however, common approac...
The diagnostic utility of SATB2 immunohistochemistry as an adjunct for differentiating osteogenic from non-osteogenic bone tumors: A systematic review and Meta-analysis [0.03%]
SATB2免疫组化鉴别骨源性肿瘤与非骨源性肿瘤诊断价值的系统评价和 meta 分析
Yuchen Lou,Xuan Liu,Chenxiao Ma et al.
Yuchen Lou et al.
Background: This study aimed to evaluate the diagnostic value of special AT-rich sequence binding protein 2 (SATB2) in distinguishing between osteogenic tumors and non-osteogenic tumors, providing reliable scientific evid...