Prospective evidence for the gut-bone axis in osteoporotic fractures: Insights from genetic prediction and metabolite mediators [0.03%]
肠道-骨骼轴在骨质疏松性骨折中的前瞻性证据：来自遗传预测和代谢物介导的启示
Binjie Zhu,Xinghao Yu,Huimin Lu et al.
Binjie Zhu et al.
Objective: To clarify the causal role of gut microbiota in osteoporotic fracture and identify underlying metabolic pathways. Method: We...
Does exercising during peri- or early post-menopause prevent bone and muscle loss: A systematic review [0.03%]
围绝经期和早期绝经后锻炼可以防止骨质和肌肉流失吗？一项系统综述
Patrick W Whitman,Christina J Alexander,Leah Kaluta et al.
Patrick W Whitman et al.
Introduction: The highest rate of bone and muscle loss occurs during the menopause transition. Yet, most clinical exercise trials have excluded peri- and early post-menopausal female participants. This systematic review a...
Altered digit tip blastema differentiation and bone regeneration in skeletally mature Ts65Dn Down syndrome mice [0.03%]
骨骼成熟的Ts65Dn唐氏综合征小鼠改变的数字尖端芽分化和骨再生
Sarah M Wolff,Ling Yu,Mingquan Yan et al.
Sarah M Wolff et al.
Down syndrome (DS), the result of Trisomy 21 (T21), is associated with accelerated aging and impacts many organ systems across the lifespan, including the musculoskeletal system. Skeletal deficits such as low bone mineral density predispose...
Chronic kidney disease- mineral and bone disorder in autosomal dominant policystic kidney disease [0.03%]
常染色体显性多囊肾病的慢性肾脏病矿物质和骨代谢异常
S Lai,A M Perrotta,L Tartaglione et al.
S Lai et al.
Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic disorder characterized by bilateral renal cysts that detach from parental tubules, progressively leading to renal function loss. Patients with ADPKD represent a...
Advancing patient evidence in XLH (APEX): Baseline analysis of a global data unification program [0.03%]
低磷血症患者的全球数据统一计划(APEX)基线分析
Thomas O Carpenter,Seiji Fukumoto,Dieter Haffner et al.
Thomas O Carpenter et al.
Purpose: X-linked hypophosphatemia (XLH) is a rare, genetic, progressive, lifelong disorder caused by pathogenic variants in the PHEX gene, leading to excess fibroblast growth factor 23 (FGF23) and renal phosphate wasting...
LIPUS promotes osteogenesis via the mcirc_9393-miR-217/326-SIRT1 axis in porous Ti6Al4V scaffolds [0.03%]
低强度脉冲超声通过mcirc_9393-miR-217/326-SIRT1轴促进多孔Ti6Al4V支架成骨作用
Hongjuan Cao,Yue Yu,Lin Wu et al.
Hongjuan Cao et al.
The repair of critical-sized bone defects remains a significant clinical challenge. Low-intensity pulsed ultrasound (LIPUS) in conjunction with scaffolds has emerged as a promising therapeutic approach. However, the osteogenic mechanisms of...
Effect of a combination of cumulative remnant cholesterol and systemic inflammation on the risk of fragility fracture: A prospective cohort study [0.03%]
残留胆固醇与系统性炎症的联合作用对脆性骨折风险的影响：一项前瞻性队列研究
Xiaoli Hou,Fuyuan Cao,Nan Zhang et al.
Xiaoli Hou et al.
We aimed to evaluate the effect of a combination of the cumulative remnant cholesterol (cumRC) concentration and the cumulative monocyte/lymphocyte ratio (cumMLR) or the cumulative systemic inflammation response index (cumSIRI) on the risk ...
Bone loss and impaired formation are associated with shared vascular changes in type 1 and type 2 diabetic mice with systemic microangiopathy [0.03%]
I型和II型糖尿病小鼠全身微血管病变与骨丢失及形成障碍的关系及其共享的血管变化
Solène Viallon,Dalia Ibarissen,Elodie Fauritte et al.
Solène Viallon et al.
Diabetes increases fracture risk, due to multifactorial bone fragility. Since bone vascularization is essential for bone health, we hypothesized that vascular alterations contribute to diabetic bone disease. We used two models of type 1 (T1...
Clinical evidence linking osteoporosis and the gut microbiome in postmenopausal females: A systematic review [0.03%]
绝经后女性骨质疏松和肠道微生物群的临床证据：系统性综述
Kyungjae Lee,Hojun Kim,Jing-Hua Wang
Kyungjae Lee
Background: Recent studies have highlighted the intricate relationship between gut microbiome (GM) and osteoporosis (OP), particularly in postmenopausal females. However, the precise mechanisms underlying this association...
Enhancing Wnt signaling lowers fracture incidence in a severe mouse model of Osteogenesis Imperfecta [0.03%]
增强Wnt信号可降低严重成骨不全症小鼠模型的骨折发生率
Giulia Montagna,Stephanie Lee,Austin Baacke et al.
Giulia Montagna et al.
Increased fracture is a hallmark feature of the skeletal disorder Osteogenesis Imperfecta (OI). A neutralizing antibody against sclerostin, an endogenous Wnt signaling inhibitor, has been FDA-approved for osteoporosis and is now in clinical...