Comparative effects of ovariectomy and chemically induced menopause on alveolar bone healing in zoledronate-treated female mice [0.03%]
卵巢切除和化学诱导绝经对唑来膦酸处理的雌性小鼠骨愈合的影响比较
Nataira Regina Momesso,Ana Carolina Zucon Bacelar-Marcolino,Claudia Cristina Biguetti et al.
Nataira Regina Momesso et al.
Alveolar socket is a highly dynamic site of bone remodeling and a clinically relevant model for studying healing disturbances associated with antiresorptive therapy. The present study aimed to investigate how different models of premature o...
Structural challenges in using Japanese claims databases for real-world evidence in osteoporosis research [0.03%]
日本骨质疏松症研究中使用理赔数据库产生真实世界证据的结构性挑战
Hiroshi Kawaguchi
Hiroshi Kawaguchi
Ixazomib treatment has a dual effect on bone remodeling in patients with multiple myeloma: follow-up results from a phase 2 clinical study [0.03%]
伊沙佐米治疗多发性骨髓瘤患者的骨骼双重作用：来自II期临床研究的随访结果
Mette Bøegh Levring,Marta Diaz-delCastillo,Michael Tveden Gundesen et al.
Mette Bøegh Levring et al.
Myeloma bone disease (MBD), a common complication in multiple myeloma (MM), causes increased risk of fractures leading to morbidity and impaired quality of life for patients. Proteasome inhibitors, a cancer-targeting therapy for MM, have be...
Exosomal miR-133b-3p modulates TGF-β1/Treg immunomodulation to ameliorate osteoporosis [0.03%]
外泌体介导的miR-133b-3p通过调节TGF-β1/Treg免疫反应改善骨质疏松症
Yun Zhao,Xingyao Yang,Jialun Wang et al.
Yun Zhao et al.
Purpose: Osteoporosis (OP) is influenced by dysregulated miRNAs, particularly during osteoblast differentiation. The precise mechanisms are still under debate. This study aimed to explore the impact of bone marrow mesench...
Sarah C Brennan,Jenny E Gunton,Arthur D Conigrave et al.
Sarah C Brennan et al.
Vitamin D is well-established in its essential role in maintaining bone health. In recent years, however, researchers have explored potential influences of vitamin D on extra-skeletal functions, with vitamin D deficiency being implicated in...
Łukasz Jaśkiewicz,Anna Romaszko-Wojtowicz,Grzegorz Chmielewski et al.
Łukasz Jaśkiewicz et al.
Myokines are cytokines secreted by skeletal muscle cells. These are cytokines with pleiotropic effects, which have receptors in different organs. Increased secretion of myokines is closely linked to physical activity, through which they aff...
Statins and longitudinal changes in vertebral bone mineral density in an emulated target trial: the multi-ethnic study of atherosclerosis [0.03%]
他汀类药物对腰椎骨密度纵向变化的影响：动脉粥样硬化的多种族研究中的模拟目标试验结果分析
Elena Ghotbi,Quincy A Hathaway,Roham Hadidchi et al.
Elena Ghotbi et al.
Background: Existing reports on the protective effects of statins on bone health have been conflicting, which may have been related to the diverse selectivity of studied populations. We aimed to evaluate the association b...
Feasibility, safety and efficacy of OsteoStrong® in postmenopausal women with low bone mineral density: A pilot study [0.03%]
低骨密度绝经后妇女使用OsteoStrong的可行性和有效性的安全性：一项试点研究
Jakub Mesinovic,Jack R Ryan,Carrie-Anne Ng et al.
Jakub Mesinovic et al.
OsteoStrong® is a brief, near-isometric loading exercise modality that targets bone health improvements by applying forces at relevant anatomical sites using specific equipment during ~10-min, once weekly sessions. Evidence on adherence, s...
Maxime Bedez,Alexandrine During,Cécile Olejnik
Maxime Bedez
Bone marrow adipose tissue (BMAT) is increasingly recognized for its role in bone physiology and pathology, yet its characteristics in the mandible remain poorly understood compared to long bones and vertebrae. This systematic review aimed ...
Dysregulation of bone and myocardial inorganic phosphate transporters and downstream cell signals in early-stage mild chronic kidney disease-mineral and bone disorder: An experimental study [0.03%]
轻度慢性肾脏病-矿物质和骨代谢紊乱早期阶段骨组织和心肌无机磷酸盐转运体及下游细胞信号失调：一项实验研究
Evdokia Bogdanova,Airat Sadykov,Galina Ivanova et al.
Evdokia Bogdanova et al.
Chronic kidney disease-mineral and bone disorder (CKD-MBD) significantly contributes to cardiovascular morbidity and mortality in CKD patients, raising questions about the molecular mechanisms linking cardiac and bone abnormalities. In this...