Relationship of growth in the first five years of life and risk of long bone fracture [0.03%]
儿童生命早期5年生长状况与长骨骨折风险的关系研究
Komal Gangar,Roshini Selladurai,Tamim Rajjo et al.
Komal Gangar et al.
Background: Birth size and early childhood growth can affect peak bone mass and later risk of osteoporosis and fracture. We examined the relationship between growth trajectory in the first 5 years of life and the risk of ...
Comment on "Impact of baseline PINP on the BMD increase with romosozumab, teriparatide, and denosumab in treatment-naïve primary osteoporosis: A retrospective cohort study" [0.03%]
关于“基线PINP对romosozumab、特立帕肽和地诺单抗治疗初治原发性骨质疏松患者骨密度增加的影响：一项回顾性队列研究”的评论
Daquan Liao,Xuezheng Zhu,Shiye Huang et al.
Daquan Liao et al.
Skin Advanced Glycation End Products (AGEs) are not associated with bone mineral density longitudinally: The Rotterdam Study [0.03%]
荷兰鹿特丹研究发现皮肤高级糖化终产物(AGEs)与骨密度纵向变化无关
Mengyuan Cai,Jinluan Chen,Jiawei Li et al.
Mengyuan Cai et al.
Background: Advanced glycation end products (AGEs), formed through non-enzymatic glycation of, e.g., proteins in collagen have been associated with prevalent fractures, but their relation with bone mineral density (BMD) a...
Decreased bone strength in skeletally mature female mice with T2D is associated with changes in OLCN and spatially compromised architecture [0.03%]
骨骼成熟的糖尿病小鼠骨强度降低与OLCN变化和空间结构受损有关
Carlos A Urrego,Benjamin S Sexton,David H Kohn
Carlos A Urrego
Women with Type-2 diabetes (T2D) have a higher incidence of fractures and associated mortality compared to men. However, most animal models for studying diabetes-induced bone effects use males and the impact of T2D on bone quality in skelet...
Piezo1-mediated mechanotransduction regulates diabetic osteoporosis and hyperglycemia via low-intensity pulsed ultrasound [0.03%]
压电蛋白1介导的机械转导通过低强度脉冲超声调节糖尿病性骨质疏松和高血糖
Mengshu Cao,Fang Pang,Xueyou Duan et al.
Mengshu Cao et al.
This study investigates the effects and mechanism by which low-intensity pulsed ultrasound (LIPUS) regulates osteoporosis and hyperglycemia in mice with type 1 diabetes mellitus (T1DM). The mice were randomly divided into four groups: norma...
FGF8 induces bone and joint regeneration at digit amputation wounds in neonate mice [0.03%]
FGF8诱导新生小鼠断趾伤口骨关节再生
Ling Yu,Mingquan Yan,Sarah M Wolff et al.
Ling Yu et al.
Due to increases in vascular diseases, the incidence of limb loss is predicted to more than double in the next quarter century. Therefore, developing a greater understanding of the latent regenerative capacity in mammals is a significant an...
A deep intronic PHEX variant in a large Danish family with hereditary hypophosphatemia and a milder skeletal, but more severe dental phenotype [0.03%]
丹麦一大家族遗传性低磷血症的深部内含子PHEX变异及其较轻的骨骼表型和更严重的牙齿表型
Jenny Blechingberg,Kristian Alsbjerg Skipper,Signe Sparre Beck-Nielsen et al.
Jenny Blechingberg et al.
Hereditary hypophosphatemia (HH) are rare diseases, characterized by excessive renal phosphate wasting, rickets and osteomalacia in growing children, and osteomalacia in adults. There are several types of HH caused by pathogenic variants in...
Association of frailty with incident fractures and the mediating effect of inflammatory biomarkers: a prospective cohort study from the UK Biobank [0.03%]
脆弱性与骨折发生关联及炎症生物标志物的中介作用：来自英国生物样本库队列研究的证据
Yi Zhang,Kai Zhang,Weizheng Kong et al.
Yi Zhang et al.
Background: Limited evidence exists regarding the association of frailty with fractures of different types and the potential mediating factors. This study investigated the prospective associations of frailty status with i...
Lyan Abdul Wadood,Victoria McHugh,Kristin K Clemens et al.
Lyan Abdul Wadood et al.
Background: Parkinson's Disease (PD) is a progressive neurodegenerative disorder that primarily affects the dopaminergic neurons in the basal ganglia. It leads to a range of motor symptoms such as tremors, bradykinesia, r...