Ernesto Canalis,Jungeun Yu,Emily Denker et al.
Ernesto Canalis et al.
A 2-month-old female child presented with a low-trauma femoral fracture, low bone mass, bowing of long bones, loss of height of a thoracic vertebra, and Wormian bones. Exome sequencing revealed the presence of a novel heterozygous 4006G > C...
Bone mineral density response to romosozumab in post-menopausal women: A prospective observational real-world study [0.03%]
关于romosozumab治疗绝经后妇女骨密度真实世界研究的前瞻性观察性研究
Evelien Gielen,Nadjia Amini,Désirée Coppens et al.
Evelien Gielen et al.
Background: Romosozumab is approved in Europe for severe osteoporosis in postmenopausal women at high risk of fracture including older women, but whether bone mineral density (BMD) response varies with age remains unknown...
Osteocyte differentiation requires glucose metabolism, but mature osteocytes display metabolic flexibility [0.03%]
成骨细胞分化需要葡萄糖代谢，但成熟成骨细胞表现出代谢可塑性
Matthew Prideaux,Mathilde Palmier,Yukiko Kitase et al.
Matthew Prideaux et al.
Recent research has identified metabolic pathways which play key roles in the differentiation and function of osteoblasts and osteoclasts. However, the mechanisms by which osteocytes, the most numerous cells in bone, meet their energetic de...
Effect of photobiomodulation on femoral fracture specimens in rats with experimentally induced osteoporosis [0.03%]
光生物调节对实验性骨质疏松大鼠股骨骨折标本的影响
João Matheus Fonseca E Santos,Rafaela Sandro Stuque,Gabriel Conceição Brito et al.
João Matheus Fonseca E Santos et al.
Bone repairing is a complex mechanism that demands good bodily conditions to happen; however, some systemic conditions can negatively influence this process, such as some chronic inflammatory conditions and changes in the microarchitecture ...
Loss of Tsc1 in Osterix-expressing cells leads to greater bone mass and strength in mice [0.03%]
Tsc1在Osterix表达细胞中的丧失导致小鼠骨量和强度增加
Han Kyoung Choi,Thomas Kim,Xiaoxi Wei et al.
Han Kyoung Choi et al.
Tuberous sclerosis complex 1 (Tsc1) negatively regulates mTORC1 signaling, but its role in postnatal skeletal development is not fully understood. Previous studies using various Cre drivers to target osteoblasts or mesenchymal lineage cells...
Autosomal recessive hypophosphatemic rickets type 2 (ARHR2): Is phosphate supplementation safe? [0.03%]
autosomal recessive假性羟磷酸盐佝偻病2型（ARHR2）：补充磷安全吗？
Martin Munteanu,Frank Rutsch,Yvonne Nitschke et al.
Martin Munteanu et al.
Introduction: Autosomal recessive hypophosphatemic rickets type 2 (ARHR2) is an ultra-rare disorder characterized by renal phosphate wasting and patients may exhibit an increased risk of vascular calcification. Phosphate ...
Cathepsin K-lineage cells and mechanical loading independently modulate bone mass in the murine tibia [0.03%]
猫溶酶体K型细胞和机械加载独立调节小鼠胫骨质量
Tyler J McNeill,Seoyeon Bok,Branden R Sosa et al.
Tyler J McNeill et al.
The ability of bone to adapt to external mechanical loads has been extensively studied, with mechanical stimuli increasing cortical and cancellous bone mass. However, the stem cell basis underlying this response is not well understood. To d...
Corrigendum to "Calorie restriction induces mandible bone loss by regulating mitochondrial function" [Bone 2025 Jan. 190:117326. doi: 10.1016/j.bone.2024.117326] [0.03%]
“热量限制通过调节线粒体功能诱导下颌骨丢失”的勘误声明（Bone杂志，2025年1月，卷号：190，DOI: 10.1016/j.bone.2024.117326）
Linyi Liu,Phuong T Le,Victoria E DeMambro et al.
Linyi Liu et al.
Published Erratum
Bone. 2025 Oct 29:117692. DOI:10.1016/j.bone.2025.117692 2025
Revealing early subchondral bone structural changes in osteoarthritis progression in a collagenase-induced mouse model using microCT [0.03%]
微计算机断层扫描下胶原酶诱导小鼠模型骨关节炎早期软骨下骨结构变化的研究
Han Liu,Zihui Li,Catherine E Davey et al.
Han Liu et al.
Osteoarthritis (OA) is the most prevalent joint disorder affecting millions of people worldwide, and involves deterioration to subchondral bone. This study aims to reveal the early bone microstructural changes at high temporal resolution in...