A comprehensive multi-layered analysis reveals genetic pleiotropy underlying coronary artery calcification and bone mineral density [0.03%]
全面的多层分析揭示冠状动脉钙化和骨矿密度的遗传多效性
Tao Han,Yang Qu,Jiangbo Zhu et al.
Tao Han et al.
Objectives: Subclinical atherosclerosis and osteoporosis are often accompanied, but their common mechanisms remain unclear. This study aims to investigate the pleiotropic relationship underlying coronary artery calcificat...
Age-related response to 12-month romosozumab in treatment-naïve Japanese women aged 55-100 years with primary osteoporosis [0.03%]
日本绝经后妇女（55-100岁）12个月Romosozumab治疗的年龄反应性分析：ROMOSO JAPAN研究的事后分析
Takaomi Kobayashi,Tomonori Kobayakawa,Yukio Nakamura
Takaomi Kobayashi
This study aimed to investigate the age-related bone mineral density (BMD) response to romosozumab. A prospective cohort study was conducted on 221 treatment-naïve women aged 55-100 years with primary osteoporosis who initiated a 12-month ...
Angiotensin receptor blockers (ARBs) but not angiotensin converting enzyme inhibitors (ACE-Is) are associated with lower osteoclast activity and higher bone mineral density: Results from the TUDA study [0.03%]
血管紧张素受体阻滞剂（而非血管紧张素转换酶抑制剂）与较低的破骨细胞活性和较高的骨密度相关：图尔萨糖尿病研究的结果
Donal Fitzpatrick,Eamon Laird,Mary Ward et al.
Donal Fitzpatrick et al.
Introduction: The renin-angiotensin system (RAS) is implicated in osteoclast activation and bone loss. We investigated the relationship of angiotensin receptor blockers (ARBs) or angiotensin-converting enzyme inhibitors (...
Response to 'reconsidering bone-muscle interactions in obese older adults with type 2 diabetes: Methodological limitations and future directions' [0.03%]
对“重新考虑肥胖的2型糖尿病老年人的骨肌相互作用：方法局限性及未来研究方向”的回应
Costas Glavas,Jakub Mesinovic,Peter R Ebeling et al.
Costas Glavas et al.
Bone size and sex are key determinants of the longitudinal bone phenotype trajectory in aging males and females [0.03%]
骨大小和性别是决定男性和女性衰老过程中纵向骨骼表型轨迹的关键因素
Annabel R Bugbird,Lauren A Burt,Danielle E Whittier et al.
Annabel R Bugbird et al.
Introduction: A previously developed phenotyping model groups common combinations of bone characteristics into three primary phenotypes: healthy, low volume, and low density from high resolution peripheral quantitative co...
Corrigendum to "Comparing bone and muscle parameters in community-dwelling older adults with obesity, with or without type 2 diabetes mellitus" [Bone 202 (2026) 117680] [0.03%]
“社区居住的老年人肥胖伴或不伴有2型糖尿病患者的骨肌参数比较”一文的勘误项（卷202，2026年，117680）
Costas Glavas,Jakub Mesinovic,Peter R Ebeling et al.
Costas Glavas et al.
Published Erratum
Bone. 2025 Nov 5:117706. DOI:10.1016/j.bone.2025.117706 2025
Bone morphogenetic protein-2-independent bone formation by human iPSC-derived megakaryocytes and platelets [0.03%]
人多能干细胞来源的巨核细胞和血小板在骨形态发生蛋白2非依赖性骨形成中的作用
Norichika Mizuki,Michiaki Mukai,Yasuhiro Shiga et al.
Norichika Mizuki et al.
Bone regeneration (BR) is an ongoing challenge in biomedical research. While recombinant human bone morphogenetic protein-2 (rhBMP-2) is available for clinical use, its side effects remain a concern. Patient-derived platelet-rich plasma has...
Melatonin promotes osteogenic differentiation of BMSCs by regulating circZFAND1/miR-433-3p/DKK1 pathway through melatonin receptor-dependent m6A modification of circZFAND1 [0.03%]
褪黑素通过依赖于褪黑素受体的m6A修饰circZFAND1调节circZFAND1/miR-433-3p/DKK1信号轴促进BMSCs成骨分化
Yubo Shi,Jianzhou Yu,Yanqing Wu et al.
Yubo Shi et al.
An effective approach for treating osteoporosis (OP) is to focus on restoring the osteogenic ability of bone marrow-derived mesenchymal stem cells (BMSCs). Melatonin (MEL) has been found to possess the capability to enhance osteogenesis. Ne...
The impact of preoperative bone mineral density on outcomes following lower extremity megaprosthetic reconstruction for oncologic resections [0.03%]
术前骨矿物质密度对恶性肿瘤切除后下肢 mega prosthesis 重建效果的影响分析
Alexandra N Krez,Nicole L Levine,Kevin A Wu et al.
Alexandra N Krez et al.
Background: While megaprosthetic reconstructions have been instrumental in restoring patients' functional abilities, surgeons remain cautious of revision risk. This is the first study to assess the impacts of preoperative...
Craniofacial fibrous dysplasia: Long-term postoperative outcomes in a retrospective case series with up to 40 years of follow-up [0.03%]
颅面纤维畸形的长期术后结果：一项回顾性病例系列研究（随访长达40年）
Pin-Ru Chen,Kai-Ti Chuang,Po-Fang Wang et al.
Pin-Ru Chen et al.
Background: Craniofacial fibrous dysplasia (CFD) is a non-malignant disease characterized by fibro-osseous lesions in the affected bones. Management is multidisciplinary, with surgery often serving as the mainstay of trea...