Fluence-dependent infrared photobiomodulation remodels chromatin architecture to enhance chemosensitivity in head and neck tumors [0.03%]
剂量依赖性的红外光生物调节可重塑头颈部肿瘤的染色质结构以增强其化学敏感性
Mariana B Ramos-Pinto,Manoela D Martins,Cristiane H Squarize et al.
Mariana B Ramos-Pinto et al.
Photobiomodulation (PBM) therapy has emerged as a noninvasive therapeutic modality capable of modulating cellular processes through the targeted delivery of light. In this study, we investigated the effects of an infrared PBM on adenoid cys...
Photobiomodulation presents an anti-inflammatory effect, reflecting on the expression of receptors related to the pain process in a collagenase-induced tendinitis experimental model [0.03%]
光生物调制通过调节与炎性痛有关的受体表达在胶原酶诱导的肌腱炎模型中表现出抗炎作用
Yose Marie Elizabeth E Silva,Patrícia de Viveiros Tavares Alves,Rachel Bharbara Maccheronio Dalmaso et al.
Yose Marie Elizabeth E Silva et al.
Pain associated with tendinopathy is a common and difficult to treat. A therapeutic strategy to control some chronic painful processes is the use of benzodiazepines, which act on their GABA receptors, producing a sedative and analgesic effe...
One-pot synthesis of conjugated small molecules for construction of NIR fluorescence/photoacoustic dual-modal imaging nanoagents with improved photothermal/photodynamic/chemodynamic effects [0.03%]
一步合成共轭小分子构建近红外荧光/光声双模成像纳米剂并改善其光热/光动力/化学动力效应
Jiaqi Li,Yanqin Huang,Guice Ding et al.
Jiaqi Li et al.
Theranostic nanoagents based on conjugated small molecules (CSMs) have attracted widespread interest in fluorescence (FL)/photoacoustic (PA) imaging and phototherapy for cancer, because CSMs exhibit not only excellent photophysical properti...
Soranjidiol as a photosensitizer: Mechanistic insights into its photochemistry and photoinduced tautomerization [0.03%]
Soranjidiol作为光敏剂：其光化学及光诱导互变异构化机理的见解
Maciej Spiegel
Maciej Spiegel
This study employs computational chemistry to evaluate soranjidiol as a potential one- and two-photon photosensitizer in photodynamic therapy. Using density functional theory, its time-dependent counterpart, and molecular dynamics, the phot...
Stimulating angiogenesis and post-ischemic tissue repair: Optimizing photobiomodulation parameters in vivo [0.03%]
调控光生物调节参数促进血管生成及缺血后组织修复的作用研究
Jaroslava Joniová,Clémence Bechelli,Sébastien Déglise et al.
Jaroslava Joniová et al.
Photobiomodulation (PBM) therapy, a non-invasive therapeutic approach utilizing red and near-infrared light at sub-thermal irradiances, presents significant potential in promoting angiogenesis and tissue repair. This study optimized PBM par...
Role of UVA-driven cellular senescence via mTOR activation in dihydrotestosterone-induced hair loss in androgenetic alopecia mouse model [0.03%]
DHT通过mTOR激活引起的UVA诱导的细胞衰老在雄激素性秃发小鼠模型中的作用研究
Dongfan Wei,Hongyan Zhang,Wen Xu et al.
Dongfan Wei et al.
Background: Androgenetic alopecia (AGA) is one of the most common forms of hair loss, and recent studies suggest that dihydrotestosterone (DHT)-induced senescence of dermal papilla cells (DPCs) plays a crucial role in its...
Therapeutic potential of wavelength-dependent photobiomodulation on gut inflammation in an in vitro intestinal model [0.03%]
波长依赖性光生物调节在体外肠道模型中治疗肠炎的潜力研究
Myungji Kang,Jihye Jo,Hwarang Shin et al.
Myungji Kang et al.
Recently, photobiomodulation (PBM) has emerged as a novel therapeutic approach for modulating the gut microbiome, offering potential for the regulation of intestinal inflammation. Although PBM has been primarily used for various clinical ap...
Infrared-A (IR-A) modulates the p53 pathway and diurnal clock in human skin and subcutaneous adipose tissue in vivo [0.03%]
红外线A（IR-A）调节体内人类皮肤和皮下脂肪组织中的p53通路和昼夜节律钟
Iina-Maria Häggqvist,Juha Jernman,Erna Snellman et al.
Iina-Maria Häggqvist et al.
Infrared-A (IR-A) radiation is thought to protect the skin from damage due to ultraviolet radiation and alter its carcinogenic potential, possibly by preventing keratinocyte apoptosis via p53 pathway modulation. Solar radiation, including I...
Hydroxyl-tunable type I photosensitizer based on curcumin for photodynamic therapy against hypoxic tumor cells [0.03%]
一种基于羟基可调式姜黄素I型光敏剂的乏氧肿瘤细胞光动力疗法
Yanping Wang,Tong Mu,Xuewei Li et al.
Yanping Wang et al.
The development of effective approaches to design type-I photosensitizers is of great importance due to their less oxygen content dependency. In this work, we report a simple strategy for the preparation of type-I photosensitizer (CNOH) by ...
Paeoniflorin protected UVA-exposed skin fibroblasts from caspase-3/GSDME mediated pyroptosis [0.03%]
芍药苷通过抑制caspase-3切割GSDMD和GSDME保护UVA诱导的成纤维细胞焦亡
Dongxin Shi,Haitao Chu,Yijun Sun et al.
Dongxin Shi et al.
Background: UVA radiation can impact fibroblasts and leads to alterations in dermal connective tissue. Pyroptosis is a form of regulated cell death characterized by gasdermin-mediated membrane pore formation and release o...