Multimodal safety assessment of repeated 650-nm red-light irradiation in chick retina [0.03%]
鸡视网膜重复暴露650nm红光的多模态安全评估研究
Chengjie He,Shiran Zhang,Yanjing Huang et al.
Chengjie He et al.
Purpose: To systematically evaluate the dose-dependent ocular safety profile and biological mechanisms of 650 nm repeated red-light (RL) therapy using the chick model. ...
A ClO--responsive porphyrin prodrug for fluorescence imaging and combined chemo-photodynamic treatment of hepatocellular carcinoma cells [0.03%]
一种用于肝癌细胞荧光成像及协同化疗与光动力治疗的ClO–响应型卟啉前药
Jinglin Gao,Lili Jia,Yibiao Liu et al.
Jinglin Gao et al.
The hypoxic tumor microenvironment (TME) of hepatocellular carcinoma (HCC) featured overexpressed hypochlorite (ClO-), which represented both a biochemical hallmark and a potential therapeutic trigger. Herein, POR-CA, a near-infrared (NIR) ...
Reversal of orthodontic movement-induced pulpal histological damages in diabetic rats by low-level laser therapy [0.03%]
低剂量激光治疗对糖尿病大鼠牙髓组织损伤的逆转作用研究
Luiz Guilherme Martins Maia,Caroline Alfaia-Silva,Matheus Antoni da Silva Costa et al.
Luiz Guilherme Martins Maia et al.
This study investigated the effect of low-level laser therapy (LLLT) on the pulpal alterations caused by tooth movement in diabetic rats. Forty-eight Wistar rats were divided into control (CTR), diabetic (DBT), and LLLT-treated counterparts...
Reversal of orthodontic movement-induced pulpal histological damages in diabetic rats by low-level laser therapy [0.03%]
低水平激光疗法对糖尿病大鼠正畸力致牙髓损伤修复的影响研究
Luiz Guilherme Martins Maia,Caroline Alfaia-Silva,Matheus Antoni da Silva Costa et al.
Luiz Guilherme Martins Maia et al.
This study investigated the effect of low-level laser therapy (LLLT) on the pulpal alterations caused by tooth movement in diabetic rats. Forty-eight Wistar rats were divided into control (CTR), diabetic (DBT), and LLLT-treated counterparts...
Melatonin as a noncanonical substrate in melanogenesis: Formation and photobiological properties of melanin-like hybrid pigments [0.03%]
褪黑素作为非经典底物在黑色素生成中的作用：类黑色素杂化色素的形成及其光生物学特性
Korneliusz D Banaś,Krystian Mokrzyński,Przemysław M Płonka
Korneliusz D Banaś
Melatonin is traditionally classified as a melanogenesis inhibitor. However, in some tissues it has been recently found to stimulate melanogenesis, paradoxically, with a parallel decrease of tyrosinase activity. This study explores this par...
Small-molecule NIR chemosensor for detecting hypochlorous acid within biosystem and visualizing cell deaths [0.03%]
用于生物系统中检测次氯酸和细胞死亡的可视化的小分子近红外化学传感器
Junyan Ma,Xiangtao Kong,He Li et al.
Junyan Ma et al.
Hypochlorous acid (HOCl), an essential endogenous reactive oxygen species, is integral to various physiological and pathological processes. It is a crucial biomarker linked to inflammation and hepatic damage. The application of near-infrare...
Development of novel nanoliposomes co-loaded with ROR1 inhibitor and Ce6 for the treatment of EGFR-TKIs resistant NSCLC by synergistic targeted inhibitor therapy and photodynamic therapy [0.03%]
开发新型纳脂质体共载ROR1抑制剂和Ce6用于表皮生长因子受体- TKI耐药非小细胞肺癌的协同靶向抑制和光动力治疗
Fang Luo,Huiyin Yang,Jie Liu et al.
Fang Luo et al.
Currently, developing effective treatments for epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) resistant non-small cell lung cancer (NSCLC) is one of the main research focuses in the field. Receptor tyrosine kinase-l...
Talaromyces spp. are tunable producers of light-activated secondary metabolites with anticancer potential [0.03%]
可调节产生光激活次级代谢产物的瘤盘菌物种具有抗癌潜力
Angelika Seeber,Vanessa Kern,Carmen Bendetta et al.
Angelika Seeber et al.
Photodynamic therapy (PDT) is a promising treatment strategy for resistant or non-surgical tumors. To develop photosensitizers tailored to specific cancer types, new chemical scaffolds are needed. Macrofungi have recently been identified as...
Delphinidin inhibits retinal photochemical damage by regulating the cGAS-STING pathway to suppress NCOA4-mediated ferritinophagy [0.03%]
delphinidin通过调节cGAS-STING信号通路抑制NCOA4介导的铁死亡自噬依赖性铁耗竭从而保护视网膜免受光损伤
Hansheng Wang,Yanfeng Zhu,Xiaolong Song et al.
Hansheng Wang et al.
Retinal photochemical damage is associated with the development of ocular diseases, yet its underlying mechanisms are incompletely defined, and therapeutic strategies are limited. Delphinidin, an anthocyanidin with broad pharmacological act...
Electrostatically assembled gold nanocluster-enhanced porphyrinic metal-organic framework nanozymes for oxygen-boosted photodynamic therapy of hypoxic tumors [0.03%]
用于缺氧肿瘤光动力疗法的静电组装金纳米团簇增强型卟啉金属有机框架类酶纳米材料
Ao He,Juan Zhou,Jing Zhu et al.
Ao He et al.
Tumor hypoxia severely limits the therapeutic efficacy of photodynamic therapy (PDT), which relies on molecular oxygen to generate cytotoxic reactive oxygen species (ROS). Herein, an electrostatically assembled gold nanocluster-porphyrinic ...