Development of novel nanoliposomes co-loaded with ROR1 inhibitor and Ce6 for the treatment of EGFR-TKIs resistant NSCLC by synergistic targeted inhibitor therapy and photodynamic therapy [0.03%]
开发新型纳脂质体共载ROR1抑制剂和Ce6用于表皮生长因子受体- TKI耐药非小细胞肺癌的协同靶向抑制和光动力治疗
Fang Luo,Huiyin Yang,Jie Liu et al.
Fang Luo et al.
Currently, developing effective treatments for epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) resistant non-small cell lung cancer (NSCLC) is one of the main research focuses in the field. Receptor tyrosine kinase-l...
Talaromyces spp. are tunable producers of light-activated secondary metabolites with anticancer potential [0.03%]
可调节产生光激活次级代谢产物的瘤盘菌物种具有抗癌潜力
Angelika Seeber,Vanessa Kern,Carmen Bendetta et al.
Angelika Seeber et al.
Photodynamic therapy (PDT) is a promising treatment strategy for resistant or non-surgical tumors. To develop photosensitizers tailored to specific cancer types, new chemical scaffolds are needed. Macrofungi have recently been identified as...
Delphinidin inhibits retinal photochemical damage by regulating the cGAS-STING pathway to suppress NCOA4-mediated ferritinophagy [0.03%]
delphinidin通过调节cGAS-STING信号通路抑制NCOA4介导的铁死亡自噬依赖性铁耗竭从而保护视网膜免受光损伤
Hansheng Wang,Yanfeng Zhu,Xiaolong Song et al.
Hansheng Wang et al.
Retinal photochemical damage is associated with the development of ocular diseases, yet its underlying mechanisms are incompletely defined, and therapeutic strategies are limited. Delphinidin, an anthocyanidin with broad pharmacological act...
Electrostatically assembled gold nanocluster-enhanced porphyrinic metal-organic framework nanozymes for oxygen-boosted photodynamic therapy of hypoxic tumors [0.03%]
用于缺氧肿瘤光动力疗法的静电组装金纳米团簇增强型卟啉金属有机框架类酶纳米材料
Ao He,Juan Zhou,Jing Zhu et al.
Ao He et al.
Tumor hypoxia severely limits the therapeutic efficacy of photodynamic therapy (PDT), which relies on molecular oxygen to generate cytotoxic reactive oxygen species (ROS). Herein, an electrostatically assembled gold nanocluster-porphyrinic ...
Genetically encoded near-infrared fluorescent protein probes based on biliverdin enable optical imaging of injury-associated phosphatidylserine in biological systems [0.03%]
基于胆绿素的遗传编码近红外荧光蛋白探针能够在生物系统中实现损伤相关磷脂酰丝氨酸的光学成像
Jing Hu,Lusheng Wu,Xueying Chen et al.
Jing Hu et al.
Optical imaging of injury-associated membrane events remains challenging because conventional fluorescent probes are often limited by tissue autofluorescence, shallow light penetration, and heterogeneous dye-to-protein labeling. Here, we re...
Guiyun Shi,Kairui Wei,Ruocun Wang et al.
Guiyun Shi et al.
Photobiomodulation (PBM) involves the application of low-intensity visible or near-infrared light (600-1100 nm) to tissues. PBM demonstrates considerable potential in chronic wound healing, neurodegenerative disease intervention, and adjunc...
Antimicrobial photodynamic therapy improves wound quality and tissue repair in diabetic foot ulcers: A randomized double blind controlled clinical trial [0.03%]
光动力治疗改善糖尿病足溃疡的质量和组织修复：一项随机双盲对照临床试验
Priscilla Farias Chagas,Thais Barbosa Dos Santos,Gesiane Dos Santos Trivino et al.
Priscilla Farias Chagas et al.
Diabetic foot ulcers have a substantial negative impact on patients' quality of life. This double blind, randomized clinical trial evaluated the association of antimicrobial photodynamic therapy (aPDT) used as an adjunct to standard wound c...
First integrated assessment of potential cutaneous vitamin D production in Riyadh: A decade of ground based measurements and culturally tailored scenario modelling [0.03%]
利雅得十年来的地面测量和文化定制情景模型的首次综合评估：潜在皮肤维生素D生成量
Abdullrahman Maghrabi,Latifah Shaber,Abdulah AlDosari et al.
Abdullrahman Maghrabi et al.
Despite abundant solar radiation year-round, vitamin D deficiency remains paradoxically widespread in Saudi Arabia - a persistent "sunshine paradox." This study presents the first integrated, decade-long assessment of potential cutaneous vi...
Improving the efficiency of a bioaerosol disinfection reactor by using ultraviolet C light-emitting diodes and titanium dioxide photocatalyst [0.03%]
基于TiO2光催化剂和UV-C LED的生物气溶胶消解反应器性能研究
Chien-Ping Wang,Bo Yu Liao,Fan-Chun Hsieh et al.
Chien-Ping Wang et al.
This study used ultraviolet (UV)-C light-emitting diodes (LEDs) and titanium dioxide (TiO2) photocatalyst to design a high-efficiency bioaerosol disinfection reactor. It conducted experiments and simulations to investigate the effects of ba...
Use of honey-derived silver nanoparticles associated with low-level laser therapy for bone defect repair in rats [0.03%]
蜂蜜衍生的银纳米颗粒联合低强度激光治疗修复大鼠骨缺损的效果研究
Armélio Vasconcelos de Siqueira Neto,Ana Claudia Souza Abreu,Carla Beatriz Dos Santos Torres et al.
Armélio Vasconcelos de Siqueira Neto et al.
Bone tissue possesses intrinsic regenerative capacity after bone defect repairs; however, delayed or compromised healing may require adjuvant therapeutic interventions. This controlled experimental study investigated the effects of low-leve...