A tumor-pH-responsive phthalocyanine as activatable type I photosensitizer for improved photodynamic immunotherapy [0.03%]
一种肿瘤pH响应型酞菁光敏剂用于增强光动力免疫治疗
Ling Zhang,Rong-Bin Que,Ting-Ting Ke et al.
Ling Zhang et al.
The development of a simple drug formulation capable of achieving both activatable type I photoreaction and tumor-responsive release of immunomodulator is crucial for advancing photodynamic immunotherapy (PDIT). Herein, we present a nanostr...
Fabrication of highly biocompatible SiO2@Au-BSA nanoconjugates: Towards a promising thermal therapy route [0.03%]
高生物相容性的SiO2@Au-BSA纳米复合材料的制备：一种前景广阔的热疗途径
Rubén Gutiérrez-Fuentes,Libertad Juárez-Santacruz,Issis Claudette Romero-Ibarra et al.
Rubén Gutiérrez-Fuentes et al.
SiO2@Au nanoshells have gained relevance in recent years, especially in biomedical areas, acting as thermal therapy agents due to their high capacity to absorb light and transform it into heat that increases the temperature of the medium. T...
ct-DNA compaction by nanoparticles formed by silica and gemini surfactants having hydroxyl group substituted spacers: In vitro, in vivo, and ex vivo gene uptake to cancer cells [0.03%]
羟基取代spacer的二氧化硅和双子表面活性剂纳米粒子介导的ct-DNA压缩：体外、体内及组织切片水平的基因传递至癌细胞
Shalini Dyagala,Sayantan Halder,Rishika Aggrawal et al.
Shalini Dyagala et al.
Hybrid nanoparticles formed by Silica (SiO2) coated with cationic gemini surfactants with variable hydroxyl group substituted spacers, 12-4(OH)-12,2Br- and 12-4(OH)2-12,2Br- have shown a great extent of compaction of calf thymus DNA (ct-DNA...
Microbiome shifts elicited by ornamental lighting of granite facades identified by MinION sequencing [0.03%]
基于MinION测序的花岗岩幕墙装饰照明引起的微生物群变化
Anxo Méndez,Francesca Maisto,Jelena Pavlović et al.
Anxo Méndez et al.
Night-time outdoor illumination in combination with natural sunlight can influence the visible phototrophic colonizers (mainly algae) growing on stone facades; however, the effects on the microbiome (invisible to the naked eye) are not clea...
The interplay between LHCSR and PSBS proteins provides photoprotection in Chlamydomonas reinhardtii pgr5 mutant under high light [0.03%]
LHCSR和PSBS蛋白互作可增强绿藻 Reinhardtii pgr5突变体的高光保护能力
Ranay Mohan Yadav,Nisha Chouhan,Jerome Xavier Gunasekaran et al.
Ranay Mohan Yadav et al.
Cyclic electron transport (CET) is a vital alternative route that protects against photodamage and aids in energy production. This process depends on proton gradient regulation 5 (PGR5) and PGRL1-dependent pathways associated with CET. The ...
Lysosome-localization and tumor-targeting of novel photosensitizers enhance the ablation of cancer [0.03%]
新型光敏剂定位至溶酶体并针对肿瘤增强癌症消融作用
Jiahui Li,Guodong Wang,Yuhan Mai et al.
Jiahui Li et al.
Lysosomes are promising therapeutic targets for cancer therapy due to their essential function and increased vulnerability in cancer cells. Herein, we report a new category of cationic photosensitizers (compounds 1-3) containing a quaternar...
In vitro and in vivo investigation of the inhibitory effects of Sinoporphyrin sodium-mediated Sonodynamic therapy on human oral squamous cell carcinoma [0.03%]
体外和体内研究塞诺吡啶钠介导的声动力学治疗对人类口腔鳞状细胞癌的抑制作用
Guogang Dong,Limin Jia,Shuhua Gao et al.
Guogang Dong et al.
Objective: Sonodynamic therapy (SDT) is an innovative, non-invasive approach to cancer treatment, by using low-intensity ultrasound to trigger the activation of sonosensitizers localized within cancerous cells. This curre...
Alterations in the mechanical properties of single dsDNA molecules, bare or cell-encapsulated, upon exposure to UVA-only radiation and sunlight [0.03%]
纯紫外线和阳光对单链双链DNA分子（带或不带细胞）力学性质的影响
Sourav Mondal,Sangheeta Bhattacharjee,Jayita Biswas et al.
Sourav Mondal et al.
Exposure to ultraviolet radiation, which leads to the formation of mutagenic and cytotoxic DNA lesions such as cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts (6-4 PPs), can be potentially fatal. The way UVA forms DNA lesions and...
Novel synthetic UV screen compounds inspired in mycosporine-like amino acids (MAAs): Antioxidant capacity, photoprotective properties and toxicity [0.03%]
受麦角固醇类似氨基酸（MAAs）启发的新型合成紫外遮蔽化合物：抗氧化能力，光防护性能和毒性
Félix L Figueroa,Pablo Castro-Varela,Julia Vega et al.
Félix L Figueroa et al.
The combination of environmental stress on the ozone layer, climate change and a greater sun exposure due to outdoor habits has led to an increase in skin cancer cases and other health issues related with UV radiation. Researchers are searc...
Synthesis of heavy-atom-free thienoisoindigo dye as near-infrared photosensitizer for type I photodynamic therapy and photoacoustic imaging [0.03%]
无重金属近红外光敏剂的合成及其在I型光动力治疗和光声成像中的应用研究
Feng Zhang,Hao Cai,Leichen Wang et al.
Feng Zhang et al.
Thienoisoindigo (TIIG) has been extensively employed as promising building block of near-infrared (NIR) dyes and organic semiconductor materials. Herein, heavy-atom-free TIIG-based NIR dye TIIGTPA is reported as photosensitizer for combinat...