Glutathione peroxidase-like activity of natural and semisynthetic phenylpropanoids and cannabinoids: An analytical investigation by a GC-MS- and HPLC-DAD-based Iwaoka's assay [0.03%]
基于GC-MS和HPLC-DAD的Iwaoka测定法对天然和半合成茋类衍生物及大麻二酚类物质谷胱甘肽过氧化物酶类似活性的分析研究
Chiara Collevecchio,Serena Fiorito,Francesco Epifano et al.
Chiara Collevecchio et al.
The present study explores the glutathione peroxidase (GPx)-like mimicking activity of selected natural phenylpropanoids, their oxyprenylated derivatives, and natural and semisynthetic cannabinoids using a revised version of Iwaoka's assay ...
Analysis of gut microbiota and intestinal secondary bile acids metabolism in rats after short-term antibiotic treatment [0.03%]
短期抗生素干预对大鼠肠道菌群及肠内次级胆酸代谢的影响分析
Zhuan Yang,Xiaoping Zhang,Bo Lv et al.
Zhuan Yang et al.
Antibiotics have a profound impact on the overall taxonomic composition of gut microbiota. As gut microbiota influence host bile acids metabolism, changes in the composition of gut microbiota induced by antibiotics are certain to alter host...
Metabolic profiling of Gegen-Qinlian Decoction and its modified formula in gut microbiota from healthy individuals and ulcerative colitis patients with different syndromes using UHPLC-QTOF-MS/MS and an in vitro incubation model [0.03%]
基于UHPLC-QTOF-MS/MS和体外孵育模型的葛芩连汤及其化裁方对健康人和不同证型溃疡性结肠炎患者肠道菌群代谢轮廓的影响研究
Zhitian Peng,Xinyi Shi,Ying Peng et al.
Zhitian Peng et al.
The efficacy of Gegen-Qinlian Decoction (GQD) and its modified formula (MGQD) against ulcerative colitis (UC) with damp-heat syndrome (UC-DHS) is closely linked to gut microbiota-mediated biotransformation. Using UHPLC-QTOF-MS/MS, this stud...
Enantioselective high-performance liquid chromatography-tandem mass spectrometry method for bioanalysis and chemical and stereochemical stability study of N-ethylpentedrone [0.03%]
N-乙基pentдрone的生物分析及化学和立体化学稳定性研究的高通量液相色谱-串联质谱法
Saba Jorbenadze,Tamar Khatiashvili,Giorgia Sprega et al.
Saba Jorbenadze et al.
The first high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method was developed for enantioselective analysis of psychoactive compound N-ethylpentedrone. The method also enabled a detection of phase-1 metabolites...
Elucidating the therapeutic mechanisms of Erzhi Pills against adenine-induced chronic kidney disease: A multi-omics study [0.03%]
基于腺嘌呤诱导的慢性肾脏病模型的二至丸治疗机制的多组学研究
Zepeng Zhang,Yujie Dai,Dandan Xu et al.
Zepeng Zhang et al.
Erzhi Pill (EZP), a classic traditional Chinese medicine formula, shows promise in ameliorating chronic kidney disease (CKD), yet its comprehensive mechanisms remain elusive. This study aimed to systematically decipher the therapeutic effec...
Biopharmaceutical assessment of naloxone permeation through human respiratory epithelial tissues: A chromatographic-mass spectrometric approach with cloud based aerosol dosing and delivery [0.03%]
气溶胶递送和基于云的给药的高效液相色谱-质谱法测定人体呼吸上皮组织中纳洛酮渗透性的生物制药评估研究
Tasmin Ara Sultana,Diaa Shakleya,Dustin G Brown et al.
Tasmin Ara Sultana et al.
Understanding naloxone permeation is important for optimizing nasal delivery and supporting comparative assessment of nasal drug products. In this study, a stability-indicating LC-MS/MS method was developed and validated for the simultaneou...
Integrated metabolomic and proteomic analysis of cardiac tissues in a murine model of Kawasaki disease [0.03%]
川崎病小鼠模型心脏组织的整合代谢组学和蛋白质组学分析
Panpan Liu,Yiyi Shen,Mingyang Zhang et al.
Panpan Liu et al.
Kawasaki disease (KD) is an acute systemic vasculitis in children that can result in severe cardiac complications. This study utilized an integrated proteomic and metabolomic approach to explore molecular dynamics in cardiac tissue from a C...
LC-MS peptide mapping of monoclonal antibodies using the mirror proteases trypsin and Tryp-N [0.03%]
利用特异切割抗体轻链和重链的胰蛋白酶和Tryp-N进行抗体肽图检测分析研究论文
Domantas Sargautis,Bernd Thiede
Domantas Sargautis
Accurate characterization of the amino acid sequence and post translational modifications (PTMs) of monoclonal antibodies (mAbs) is essential for evaluating product quality. Peptide mapping through bottom-up LC/MS analysis is a key methodol...
Identification and characterization of trametinib degradation product employing Orbitrap LC-HRMS, and development of a robust, eco-friendly stability indicating method of analysis [0.03%]
基于轨道阱液相-高分辨质谱的曲美替尼降解产物鉴定及结构确证和环境友好型降解行为研究指示性分析方法的建立
Sohan G Jawarkar,Gayatri Amliyar,Nasir Khan et al.
Sohan G Jawarkar et al.
Trametinib is a selective MEK1/2 inhibitor approved for the treatment of various cancers. Stress testing of a drug is essential for understanding the stability profile and ensuring compliance with regulatory requirements during pharmaceutic...
Identification of leprosy reactions using Fourier transform infrared (FTIR) spectroscopy supervised by clinical evaluation [0.03%]
基于临床评价的傅里叶变换红外光谱识别麻风反应
Paulo Cezar de Moraes,Alessandra Koehler,Letícia Maria Eidt et al.
Paulo Cezar de Moraes et al.
Leprosy is a chronic granulomatous, infectious and disabling disease, whose etiological agents are Mycobacterium leprae and M. lepromatosis. Leprosy reactions are the main causes of peripheral nerve damage and sequelae of the disease. There...