NMR-based serum metabolomics reveals diabetes-linked metabolic reprogramming in early-stage chronic kidney disease [0.03%]
基于核磁共振的血清代谢组学揭示了慢性肾脏病早期糖尿病相关代谢重构
Upasna Gupta,Amrita Sahu,Anupama Kaul et al.
Upasna Gupta et al.
Early-stage chronic kidney disease (CKD) is usually asymptomatic, and the presence of type 2 diabetes mellitus (T2DM) accelerates metabolic alterations long before conventional clinical markers detect changes. Despite their strong clinical ...
Simultaneous analysis of various anticancer drugs by supercritical fluid chromatography-mass spectrometry. Part II: Method validation and comparison with liquid chromatography [0.03%]
多种抗肿瘤药物同时分析的超临界流体色谱-质谱法（第二部分）：方法验证与液相色谱比较
Virginie Vallet,Nathalie Nguyen,Serge Rudaz et al.
Virginie Vallet et al.
A complete SFC-MS/MS method validation enabling the simultaneous trace-level analysis of 27 conventional anticancer drugs (CADs) was performed. The selected drugs were the following: 5-fluorouracil, azacitidine, busulfan, carboplatin, cispl...
First enantioselective determination of N-ethylpentedrone and its major phase-1 metabolites using supercritical fluid chromatography coupled with tandem mass spectrometry and its application to human oral fluid and urine samples [0.03%]
使用超临界流体色谱-串联质谱法首次对映选择性测定N-乙基戊嘟酮及其主要I相代谢产物及其在人体口腔液体和尿液样品中的应用
Saba Jorbenadze,Aluda Tchelidze,Giorgia Sprega et al.
Saba Jorbenadze et al.
The enantioselective bioanalysis of synthetic cathinones and their metabolites remains analytically challenging. Due to the basic nature of these compounds, mobile phases with elevated pH are preferable for their analysis in high-performanc...
Optimized UHPLC-derivatization method for low-level nitrite detection in pharmaceutical excipients [0.03%]
用于药物辅料中低浓度亚硝酸盐检测的优化UHPLC 衍生化方法
Róbert Kormány
Róbert Kormány
This work presents a method optimization strategy for determining nitrite ions in pharmaceutical excipients. After derivatization, nitrite ions were analyzed using ultra-high-pressure liquid chromatography with UV detection. The article det...
Microstructural analysis of PLGA-PEG-PLGA copolymer based on NMR spectroscopy using model compounds [0.03%]
基于模型化合物的NMR光谱分析PLGA-PEG-PLGA共聚物的微观结构
Bartosz Strus,Jerzy Sitkowski,Arkadiusz Szterk
Bartosz Strus
This study presents a novel strategy for studying the microstructure of PLGA-PEG-PLGA triblock copolymers synthesized via the ROP mechanism using various organic catalysts. The use of model copolymers (PLG-PEG-PLG, PLA-PEG-PLA) and multidim...
A universal immunocapture LC-MS/MS method for humanized IgG1-based drugs in cynomolgus monkeys [0.03%]
一种用于食蟹猴中人源化IgG1类药物的通用免疫捕获LC-MS/MS方法
Pei Pang,Pingping Yin,Yimin Tao et al.
Pei Pang et al.
The application of immunocapture LC-MS/MS in drug testing has expanded considerably over the past decade, offering significant advantages in analysis, development, and identification. In this study, we developed and validated a universal im...
Pharmacokinetic-pharmacodynamic modeling of Laportea bulbifera extract in adjuvant-induced arthritis rats via joint cavity microdialysis [0.03%]
微透析联合腔给药法评价拉波尔tea bulbifera茎提取物治疗佐剂型大鼠关节炎的药代动力学和量效关系研究
Siying Chen,Dan Lu,Kang Yang et al.
Siying Chen et al.
This study developed a local pharmacokinetic-pharmacodynamic (PK-PD) model for Laportea bulbifera extract (LBE) in the joint cavity of adjuvant-induced arthritis (AA) rats using microdialysis technology. A stable intra-articular microdialys...
LC-MS/MS metabolite profiling, molecular networking and cyclooxygenase inhibition activity of Hornstedtia conoidea and Etlingera elatior extracts: In vitro and in silico insights [0.03%]
Hornstedtia conoidea和Etlingera elatior提取物的LC-MS/MS代谢组学、分子网络分析及体外和基于计算机的环氧化酶抑制活性研究
Jason C Alcano,Anna Karen C Laserna,Mark Tristan J Quimque et al.
Jason C Alcano et al.
Inflammation is a complex physiological response implicated in infectious and metabolic diseases. Although nonsteroidal anti-inflammatory drugs (NSAIDs) effectively reduce inflammation through cyclooxygenase (COX) inhibition, their poor iso...
Unraveling the phenolic profiles of Clinopodium bolivianum (Benth.) Kuntze and Minthostachys mollis (Benth.) Griseb.: A comprehensive LC-QtoF metabolomic study of underexplored Peruvian medicinal plants [0.03%]
基于LC-QtoF代谢组学的秘鲁药用植物Clinopodium bolivianum（Benth）. Kuntze和Minthostachys mollis（Benth）. Griseb.酚类化合物剖面解析及综合评价研究
Natalia García-Acosta,Ignacio Moratilla-Rivera,Marta Jordán et al.
Natalia García-Acosta et al.
Medicinal plants remain a primary healthcare resource worldwide, particularly in regions with strong cultural traditions and limited economic development. In Peru, muña [Minthostachys mollis (Benth.) Griseb.] and inca muña [Clinopodium bo...
Study of GJKBW against RA based on the Chinmedomics combined LIP-MS molecular fishing technology: A new strategy for discovering the therapeutic material basis [0.03%]
基于中医药信息学结合液相质谱分子钓技术的葛均波方抗炎作用物质基础研究新策略
Xin Zha,Long-Yu Yao,Wen-Wei Gong et al.
Xin Zha et al.
Rheumatoid arthritis (RA) is a major chronic autoimmune disease. Current conventional drugs face significant challenges, including severe side effects, high recurrence rates, and unsuitability for long-term use. In contrast, traditional Chi...