Volatilomic analysis of blood and urine by headspace solid-phase microextraction gas chromatography/mass spectrometry for complementary assessment of chronic kidney disease [0.03%]
顶空固相微萃取气相色谱/质谱挥发性组学分析在慢性肾脏病互补诊断中的应用研究
Giulia My,Angiola Forleo,Alessandra Aloisi et al.
Giulia My et al.
Chronic Kidney Disease (CKD) is a progressive disorder requiring strategies for early detection and disease stratification. In this context, volatilomics represents a promising analytical approach for investigating metabolic alterations thr...
An analytical quality by design-guided method development for the quantification of N-nitroso-fluoxetine to support mitigation strategies for a fluoxetine drug product [0.03%]
支持氟西汀药物产品的缓解策略的N-亚硝基-氟西汀定量分析的质量源于设计的的方法开发
Yue Zhang,Pierre-Yves Sacré,Bruno Streel et al.
Yue Zhang et al.
This work focused on N-nitroso-fluoxetine, a N-nitrosamine drug substance-related impurity (NDSRI) formed in fluoxetine-containing products via nitrosation pathways. N-nitroso-fluoxetine was previously detected above the established safety ...
High-throughput screening and quantification of eight anti-dandruff agents and antibiotics in hair care products by direct analysis in real-time high-resolution mass spectrometry and HPLC [0.03%]
基于直接电离高分辨质谱和HPLC的头发护理产品中八种去屑剂及抗生素的高通量筛查与定量方法研究
Jing Sun,Dan-Yi Jiang,Hui-Min Qiang et al.
Jing Sun et al.
Unregistered and excessive use of restricted anti-dandruff agents and the illegal addition of prohibited antibiotics in hair care products pose growing concerns, but monitoring is complicated by lack of integrated screening workflows, as we...
Biosensing technologies for cannabinoid monitoring in pain management: Current methods, clinical needs, and translational challenges [0.03%]
疼痛管理中的大麻素监测生物传感技术：当前方法、临床需求和转化挑战
Shakti Banik,Jessica Fales,Jong-Hoon Kim
Shakti Banik
Cannabinoids such as Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are increasingly explored for chronic and neuropathic pain management. Still, their clinical use remains limited by variable formulations, uncertain therapeutic range...
Identification of related substances in baloxavir marboxil using 2D-LC-Q-TOF/MS [0.03%]
采用二维液相色谱-四极杆飞行时间质谱法分析巴洛沙韦的杂质
Zhi-Tong Liu,Meng Ji,Yan-Rong Yao et al.
Zhi-Tong Liu et al.
Baloxavir marboxil, a novel RNA polymerase inhibitor for the treatment of influenza, suppresses viral replication at the initiation stage of RNA transcription and has demonstrated significant clinical efficacy in reducing viral load and rap...
In depth study on the mechanism of Xiao-Chai-Hu-Tang in ameliorating irinotecan-induced intestinal toxicity and enhancing antitumor immunity via intestinal microbiota and fecal metabolomics [0.03%]
小柴胡汤改善伊立替康致肠道毒性的机制及其通过肠菌和粪便代谢组提升抗肿瘤免疫能力的深入研究
Yangyang Zhang,Xia Cao,Zong Hou et al.
Yangyang Zhang et al.
Irinotecan (CPT-11) is a cornerstone chemotherapeutic for advanced colorectal cancer (CRC), but its clinical use is limited by dose-dependent gastrointestinal (GI) toxicity. Xiao-Chai-Hu-Tang (XCHT), a classical traditional Chinese medicine...
Rapid screening of physicochemical compatibility between co-administered injectable drugs using thermal and spectroscopic approaches [0.03%]
基于热分析和光谱法的注射给药合用药物物理化学相容性快速筛选方法研究
Pedro A Granados,Ingrid A Santana,Ana Luiza Lima et al.
Pedro A Granados et al.
The concomitant administration of injectable drugs in hospital settings frequently involves extemporaneous combinations within the same infusion line, often without compatibility evaluation. This practice may compromise drug stability and p...
Comprehensive solution NMR characterization of bivalirudin, a direct thrombin inhibitor peptide, and its process impurities by heteronuclear spectral fingerprinting at natural isotopic abundance [0.03%]
全同位素天然丰度下杂核谱指纹图谱在直接凝血酶抑制剂肽巴利用定及其工艺杂质的综合性NMR表征
Subrata H Mishra,Anupreet Kaur,Duyen Vu et al.
Subrata H Mishra et al.
Bivalirudin is a 20-residue synthetic peptide that functions as a bivalent thrombin inhibitor by simultaneously engaging thrombin's active site and exosite I. Despite its widespread clinical use, comprehensive NMR-based characterization of ...
Md Shah Alam,Kanti Sapkota,Jacob Hill
Md Shah Alam
A unique combination of properties, such as heat resistance, transparency, and high deformability, has led to wide adoption of silicone rubber as a material of construction in medical devices. Potential toxicity of medical devices and their...
Differential impedimetric sensing of arboviruses using a lectin-modified hybrid polypyrrole-gold nanoparticle platform [0.03%]
基于金纳米粒子-聚吡咯杂化平台的凝集素阻抗传感检测虫媒病毒
Vitoria R R Oliveira,Alberto G Silva-Junior,Marli T Cordeiro et al.
Vitoria R R Oliveira et al.
Arboviruses remain a major global public health concern, particularly Dengue (DENV), Zika (ZIKV), and Chikungunya (CHIKV), whose co-circulation and overlapping symptoms lead to challenging diagnosis. Due to their sensitivity and compatibili...