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Jiuwei Qianghuo Granules (JWQHG), a classical traditional Chinese medicinal preparation composed of nine herbs, has been widely used in clinical practice for centuries. However, its chemical composition and metabolic fate in vivo remain ins...
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Fast, noninvasive and cost-effective methods for screening colorectal cancer (CRC) before uncomfortable colonoscopy are highly desirable. This study aimed to explore the feasibility of using near-infrared spectroscopy (NIRS) combined with a...
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Gangling Xu,Sihan Wei,Gang Wu et al.
Gangling Xu et al.
Antibody-drug conjugates (ADCs) combine the dual characteristics of antibody targeting and high payload potency. ADCs represent a key technology in targeted therapy and have become a major direction in "precision" medicine. Charge variants ...
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The significant impact of depression on human life has attracted great attention. However, the unclear and highly complex pathogenesis of depression has resulted in the limited efficacy of currently available antidepressants. Therefore, it ...
Simultaneous quantification of fat- and water-soluble vitamins in serum by valve-mediated dual LC-MS/MS [0.03%]
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Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the benchmark platform for multiplex vitamin quantification, yet simultaneous determination of chemically disparate fat-soluble (FSVs) and water-soluble vitamins (WSVs) remains an...
Counterfeit thyroid medications: A comprehensive analysis of the composition of products seized by law enforcement using liquid chromatography coupled with mass spectrometry [0.03%]
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Drug counterfeiting is a global public health challenge affecting both developed and developing countries. This study reports the first comprehensive quality assessment of falsified medicinal products containing thyroid hormones (liothyroni...
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Kaining Zhou et al.
Traditional Chinese medicine (TCM) injections require stringent batch-to-batch quality control. This study established a digital, multidimensional fingerprinting workflow for Ixeris sonchifolia (Bunge) Hance injection (ISHI), integrating: (...
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Jiajun Weng,Luyao Huan,Shiyu Zhang et al.
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Chuanzhi Qingyu (CZQY) recipe is clinically used for the secondary prevention and treatment of cardiovascular diseases associated with atherosclerosis (AS) However, the potential active components and underlying molecular mechanisms require...
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Infant and baby foods may contain nitrate and nitrite due to the accumulation of these ions in plant-based ingredients, and although nitrate itself is not acutely toxic, its potential conversion to nitrite and subsequent health risks necess...