Comprehensive solution NMR characterization of bivalirudin, a direct thrombin inhibitor peptide, and its process impurities by heteronuclear spectral fingerprinting at natural isotopic abundance [0.03%]
全同位素天然丰度下杂核谱指纹图谱在直接凝血酶抑制剂肽巴利用定及其工艺杂质的综合性NMR表征
Subrata H Mishra,Anupreet Kaur,Duyen Vu et al.
Subrata H Mishra et al.
Bivalirudin is a 20-residue synthetic peptide that functions as a bivalent thrombin inhibitor by simultaneously engaging thrombin's active site and exosite I. Despite its widespread clinical use, comprehensive NMR-based characterization of ...
Md Shah Alam,Kanti Sapkota,Jacob Hill
Md Shah Alam
A unique combination of properties, such as heat resistance, transparency, and high deformability, has led to wide adoption of silicone rubber as a material of construction in medical devices. Potential toxicity of medical devices and their...
Differential impedimetric sensing of arboviruses using a lectin-modified hybrid polypyrrole-gold nanoparticle platform [0.03%]
基于金纳米粒子-聚吡咯杂化平台的凝集素阻抗传感检测虫媒病毒
Vitoria R R Oliveira,Alberto G Silva-Junior,Marli T Cordeiro et al.
Vitoria R R Oliveira et al.
Arboviruses remain a major global public health concern, particularly Dengue (DENV), Zika (ZIKV), and Chikungunya (CHIKV), whose co-circulation and overlapping symptoms lead to challenging diagnosis. Due to their sensitivity and compatibili...
Unravelling metabolites conferring intestinal protection in asymptomatic first-degree relatives of patients with celiac disease [0.03%]
无症状乳糜泻患者一级亲属肠道保护代谢物的研究
Deepti Upadhyay,Prasenjit Das,Siddhartha Dattagupta et al.
Deepti Upadhyay et al.
Celiac disease (CeD) is an autoimmune enteropathy; nearly 60-80% of first-degree relatives (FDRs) of CeD patients carry HLA-DQ2/DQ8 haplotypes; however, only 7.5% of them develop enteropathy. This suggests the modulation of biochemical and ...
Biomimetic chromatographic descriptors for modeling therapeutic, toxic, and lethal blood concentration endpoints: convergence with conventional physicochemical properties [0.03%]
用于模拟治疗、毒性和致死的血药浓度终点的仿生色谱描述符：与传统的物理化学性质的一致性
Chrysanthos Stergiopoulos,Klara Valko
Chrysanthos Stergiopoulos
Blood concentration thresholds associated with therapeutic, toxic, and lethal effects reflect distribution-related processes but also pharmacodynamic, clinical, and forensic factors. This study examined whether biomimetic chromatographic de...
Implications of formulation change on the in-use stability of compounded pemetrexed infusion bags: Impact of excipients, solvent and storage conditions [0.03%]
配制的培美曲塞输液袋配方变更对其使用稳定性的的影响：辅料、溶剂和储存条件的影响
Loup Nobilet,Philippe-Henri Secretan,Audrey Solgadi et al.
Loup Nobilet et al.
Pemetrexed diluted infusions are often prepared in advance for hospital use. Since patent expiry of the originator, several generics with different formulations and stability claims have become available, but the influence of formulation va...
Development and validation of reversed phase-high-performance liquid chromatography method for simultaneous quantification of temozolomide and alpha-lipoic acid in bulk and lipidic nanovesicles [0.03%]
用于批量和脂质纳米囊泡中替莫唑胺和α-硫辛酸的同时定量的反相高效液相色谱法的开发与验证
Sajidul Hoque,Vinod L Gaikwad
Sajidul Hoque
A new and precise single-isocratic reversed-phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for the simultaneous analysis of Temozolomide (TMZ) and Alpha-lipoic acid (ALA) in bulk and lipidic nanove...
Electron-activated dissociation for structural resolution of lipid isomers: Principles, performance, and the path to routine workflows [0.03%]
电子活化解离法解析脂质异构体结构：原理、性能和常规工作流程的路径
Carolina Gonzalez-Riano
Carolina Gonzalez-Riano
Lipids encode critical biological information not only through their class and sum composition, but also through fine structural features, including fatty acyl chain stereospecific numbering (sn) position in glycerolipids and glycerophospho...
Forced degradation study of abacavir using the electrochemistry-mass spectrometry setup [0.03%]
高效液相色谱-电化学检测器-串联质谱法研究阿巴卡韦的强制降解行为
Filip Vymyslický,Jan Fischer,Jakub Heřt et al.
Filip Vymyslický et al.
This article investigates the electrochemical oxidation of abacavir using a simple online setup, coupling an electrochemical flow cell with a mass spectrometer, as an alternative approach to forced oxidative degradation studies. Electrochem...
Synergistic profiling of Angelicae sinensis Radix-Cinnamomi Cortex: Comparative pharmacokinetics, tissue distribution, excretion, and in sillico metabolism prediction [0.03%]
当归与肉桂药效物质的协同分析及其比较药动学、组织分布、排泄和体外代谢预测研究
Wenkai He,Shuyi Liao,Yiping Jiang et al.
Wenkai He et al.
Angelicae sinensis Radix-Cinnamomi Cortex herb pair (ACHP) is extensively utilized in traditional Chinese medicine (TCM) formulas to dispel cold, tonify kidney yang and relieve pain. However, the in vivo dynamics of its bioactive constituen...