A universal LC-HRMS workflow integrating targeted and untargeted strategies for rapid and comprehensive metabolite profiling of oligonucleotide-based therapeutics [0.03%]
一种集成靶向和非靶向策略的通用LC-HRMS工作流程，可快速全面地对寡核苷酸药物进行代谢产物谱分析
Yuqing Zhao,Yue Yang,Mingshe Zhu et al.
Yuqing Zhao et al.
Metabolite profiling and identification of oligonucleotide-based therapeutics (OBTs) is important in drug discovery and development. Conventional liquid chromatography-high resolution mass spectrometry (LC-HRMS) methods (using ProMass, BioP...
Simultaneous identification of 50 illegal adulterants in dietary supplements using high-performance liquid chromatography-single quadrupole mass spectrometry [0.03%]
一种用于膳食补充剂中同时鉴定50种非法添加物的高效液相色谱-单四极杆质谱法
Takayuki Sakai,Misa Tanaka,Yuki Azuma et al.
Takayuki Sakai et al.
Health hazards associated with the ingestion of dietary supplements containing illegal adulterants have been reported. High-performance liquid chromatographysingle quadrupole mass spectrometry (LC-MS) is useful for identification of illegal...
Preparation of Novel magnetic boronic acid-affinity material and investigation of adsorption performance toward ovalbumin [0.03%]
新型磁性硼酸亲和材料的制备及对卵清蛋白吸附性能的研究
Xiao Dong,Jianliang Li,Yixuan Ni et al.
Xiao Dong et al.
Glycoproteins play a crucial role in various biological processes, including protein folding, information transmission, nerve conduction, and molecular recognition. In this study, a novel magnetic phenylboronic acid-functionalized covalent ...
Development of a reliable and convenient lateral flow immunoassay for dihydromyricetin detection in Ampelopsis grossedentata samples [0.03%]
一种可靠简便的大型齿叶地菍中双氢杨梅素横向免疫层析检测方法开发研究
Xueyan Cui,Zhen Cao,Hailong Yu et al.
Xueyan Cui et al.
Dihydromyricetin, a flavonoid abundant in Ampelopsis grossedentata distributed across southern China, exhibits diverse pharmacological activities. In this study, a precise, sensitive, rapid, and reliable lateral flow immunoassay (LFIA) was ...
Quantification of Polymyxin E in Plasma and Epithelial Lining Fluid: Validation and Clinical Application [0.03%]
多黏菌素E在血浆和上皮细胞衬里液中的定量：验证及临床应用
Shengnan Zhang,Ruwei Yang,Hongyi Tan et al.
Shengnan Zhang et al.
Polymyxin E (PME) is an essential "last-resort" antibiotic for multidrug-resistant Gram-negative infections, but its narrow therapeutic window and high pharmacokinetic variability necessitate therapeutic drug monitoring (TDM). In this study...
A quantitative, broad-panel LC-MS/MS method for the analysis of intact steroid conjugates: A novel approach to steroid profiling for biomarker research in corticoid-dependent diseases [0.03%]
一种用于完整类固醇共轭物分析的定量、广谱LC-MS/MS方法：在皮质类固醇依赖性疾病生物标志物研究中进行类固醇谱分析的新方法
Eleanor North,Arne Gessner,Max Kurlbaum et al.
Eleanor North et al.
In endocrine oncology changes in hormone synthesis and metabolism play a major role in disease formation and progression. Accordingly, steroid metabolism is a possible pathophysiological factor in adrenal tumours and metabolic conjugates of...
A MA-SSA-optimized XGBoost-MLP framework using LIBS for rapid classification and quantitative analysis of heavy metals in traditional chinese medicines [0.03%]
基于LIBS的重金属快速分类和定量分析的MA-SSA优化的XGBoost-MLP框架
Abulimiti Yasen,Yuxia Zhou,Wenhan Gao et al.
Abulimiti Yasen et al.
Laser-Induced Breakdown Spectroscopy (LIBS) holds significant value for rapid elemental detection; however, strong spectral interference, matrix effects, and high-dimensional data characteristics pose considerable challenges to accurate qua...
Economical chiral and achiral separation of seven impurities in brivaracetam by supercritical fluid chromatography with polysaccharide-based chiral stationary phases [0.03%]
采用多糖手性固定相超临界流体色谱法对手性及非手性溴瓦酯胺杂质进行经济分离
Qingying Jia,Xiaodan Qiu,Xuejia Zhao et al.
Qingying Jia et al.
Due to the presence of multiple chiral centers in its structure, the analysis of brivaracetam and its enantiomers, diastereomers, as well as non-isomeric impurities imposes high requirements on the separation capability of chromatographic m...
Evaluation of photochemical behavior of ebastine and elucidation of its photoproducts [0.03%]
依巴斯汀光降解产物的研究及其生成途径分析
Kohei Kawabata,Yukina Tokunaga,Yoko Nunome et al.
Kohei Kawabata et al.
Ebastine (EB) is a second-generation histamine H1 receptor antagonist and utilized for the relief of allergy symptoms. In this study, the photodegradability of EB in an aqueous media was evaluated and the chemical structures of generated ph...
Identification and quantification of sesquiterpenes, alkaloids, flavonoids and coumarins in Artemisia annua L: Potential artemisinin activity-enhancing compounds [0.03%]
识别并量化艾纳香中的倍半萜、生物碱、黄酮和香豆素：潜在的提高青蒿素活性的成分
Jing Zhang,Shuaichen Zhang,Cheng Wang et al.
Jing Zhang et al.
Artemisia annua L. (qinghao) is renowned for its antimalarial properties, primarily attributed to artemisinin. However, the compounds that can enhance the antimalarial activity of artemisinin have not been fully explored. Here, we performed...