Identification of anti-NSCLC bioactive compounds from Euphorbia helioscopia L. through integrated pharmacological classification and metabolomics analysis [0.03%]
通过整合药理学分类和代谢组学分析从Euphorbia helioscopia L.中鉴定抗非小细胞肺癌活性化合物
Xiaomei Yu,Caihong Bai,Tao Wang et al.
Xiaomei Yu et al.
Euphorbia helioscopia L. (commonly known as Zeqi) has been reported to possess anti-tumor potential, however, its bioactive constituents and underlying molecular mechanisms against non-small cell lung cancer (NSCLC) remain to be elucidated....
Assessment of heavy metal contamination and source apportionment in smokeless tobacco products: Implications for human exposure and health risk [0.03%]
无烟烟草产品中重金属污染的评估及来源解析：对人类暴露和健康风险的影响
Rushikesh D Bandal,Saurabh Bodake,Sai Sharanya Pulimamidi et al.
Rushikesh D Bandal et al.
Smokeless tobacco (SLT) is highly used and associated with negative health effects, and therefore, it has to be strictly regulated. This study assessed the levels of heavy metals and their associated health hazards in SLT products found in ...
Study on the correlation between external traits and intrinsic quality of Pseudostellariae Radix based on intelligent sensory evaluation and DESI-MSI technology [0.03%]
基于智能感官评价和DESI-MSI技术的明党参药材外特征与内质相关性研究
Ziqiang Liu,Tongtong Han,Shiao Wu et al.
Ziqiang Liu et al.
Currently, the quality analysis methods for Pseudostellariae Radix (PR) are often time-consuming, costly, and operationally complex, which hinders growers, distributors, and consumers from making rapid, preliminary judgments regarding its i...
Stoichiometric simultaneous quantification of mycophenolate mofetil and mycophenolic acid in paired culture medium and cell extracts by common product ion LC-MS/MS [0.03%]
等摩尔同时定量培养基和细胞提取物中的霉酚酸酯和霉酚酸的常见产物离子LC-MS/MS方法
Ushio W Ishikawa,Hirotaka X Kanoh,Kei Irie et al.
Ushio W Ishikawa et al.
Mycophenolate mofetil (MMF) is an immunosuppressive prodrug whose efficacy depends on conversion to mycophenolic acid (MPA). Quantitative, stoichiometry-ready measurement of MMF-to-MPA conversion in matched extracellular and intracellular m...
UPLC-MS/MS method for quantifying non-stimulant ADHD medications in human breast milk and plasma: Application in a lactating patient receiving atomoxetine [0.03%]
一种用于人体乳汁和血浆中非兴奋性ADHD药物定量的UPLC-MS/MS方法：在使用阿托莫西汀治疗哺乳期患者中的应用
Ryoichi Aoyagi,Ayako Furugen,Ayako Nishimura et al.
Ryoichi Aoyagi et al.
Non-stimulant medications, such as atomoxetine (ATX) and guanfacine (GFC), are increasingly prescribed for attention-deficit/hyperactivity disorder (ADHD), including among women of childbearing age. However, experimental data on the transfe...
Top-down measurement uncertainty for subvisible particles by light obscuration in injections - Uncertainties from precision and recovery studies [0.03%]
基于注射液中亚可见颗粒光阻法的自上而下测量不确定度-来自精密度和回收率研究的不确定度
Matheus Bergamini Silva,Felipe Rebello Lourenço
Matheus Bergamini Silva
The subvisible particle counting by light obscuration is a critical quality control test in injectable drug products. Incorrect conformity decisions, particularly false acceptance of non-compliant batches, may result in significant health r...
Development and exploratory evaluation of a quantitative immunochromatographic assay for serum ACOX1 in intrahepatic cholestasis of pregnancy [0.03%]
宫内妊娠肝内胆汁淤积症定量免疫层析测定的建立及探索性评估研究
Jianyi Gao,Xiaojin Yang,Linxia Shuang et al.
Jianyi Gao et al.
Serum biomarkers play a key role in the early diagnosis and risk stratification of intrahepatic cholestasis of pregnancy (ICP). Our previous study showed that acyl-CoA oxidase 1 (ACOX1) was elevated in the serum and placenta of ICP patients...
Integration of multidimensional data acquisition and data processing strategy for comprehensive characterization of chemical constituents in Qingre Sanjie capsule by UPLC-TWIMS-QTOF-MS and molecular networking [0.03%]
基于UPLC-TWIMS-QTOF-MS和分子网络的青热三解胶囊化学成分整体识别的多维数据获取及处理策略集成整合研究
Shiyu Zhang,Siyi Ma,Xi Chen et al.
Shiyu Zhang et al.
Molecular networking (MN) is widely utilized in the compositional analysis of herbal medicines and complex formulations. While the technique effectively links compounds through shared MS2 fragmentation patterns and structural homology, it i...
Rapid subunit-level multi-attribute monitoring of succinimide and other PTMs for enhanced quality control of therapeutics antibodies [0.03%]
基于亚基水平的快速多属性监测技术评估药物抗体中的琥珀酸酯等PTMs改善质控标准
Jin Xu,Chenjing Xu,Gang Wu et al.
Jin Xu et al.
Succinimide (Asu), a critical intermediate in asparagine deamidation and aspartic acid isomerization, represents a potential critical quality attribute (CQA) of therapeutic antibodies but remains challenging to accurately quantify due to it...
Development of rapid diagnostic kit against sepsis: Barcode-based semi-quantitative measurement of C-reactive protein and lactate [0.03%]
一种快速诊断试剂盒的开发——基于条形码技术对C反应蛋白和乳酸进行半定量检测以对抗脓毒血症
Ege Gokce Savas,Ekrem Tinaz,Figen Coskun et al.
Ege Gokce Savas et al.
This study reports the development of a point-of-care (POC) detection platform integrating lateral flow immunoassays (LFIAs) and paper-based enzymatic sensors for the semi-quantitative measurement of C-reactive protein (CRP) and lactate, tw...