Development of an immobilized Mycobacterium tuberculosis purine nucleoside phosphorylase platform for ligand fishing and inhibition assays [0.03%]
一种用于诱饵发现和抑制实验的固定化的分枝杆菌鸟嘌呤核糖核苷酸磷酸酶平台的发展
Isabella Sant&#x;Anna,Rafaella Silva Arêdes,Walter Claudino P de Souza et al.
Isabella Sant&#x;Anna et al.
Purine nucleoside phosphorylase (PNP) from Mycobacterium tuberculosis (MtPNP) plays a crucial role in purine metabolism, making it an attractive target for developing new tuberculosis treatments. In this study, we developed a ligand screeni...
Determination of sacubitril and seven sartan drugs in serum samples by online solid phase extraction-liquid chromatography-tandem mass spectrometry [0.03%]
在线固相萃取-液相色谱-串联质谱法测定血浆中沙库必曲酯和七种沙坦类药物
Yanan Guo,Shuang Cao,Bin Geng et al.
Yanan Guo et al.
An online solid phase extraction-ultra performance liquid chromatography-tandem mass spectrometry detection method was developed for the simultaneous determination of sacubitril and seven sartan drugs in blood serum in this study. The compo...
Nitrogen dioxide sterilization of a set of five ophthalmic active pharmaceutical ingredients: Impact on impurity profile and content [0.03%]
二氧化氮对五种眼科原料药物活性成分进行灭菌：对杂质谱和含量的影响
Elias Vanneste,Quinten Speleers,Anke Meyers et al.
Elias Vanneste et al.
Literature about sterilization of pharmaceutical substances is limited. The aim of this study was to evaluate the effect of nitrogen dioxide (NO2) sterilization, a new emerging technology, on five different ophthalmic active pharmaceutical ...
Discovery of potential female-specific biomarkers for major depressive disorder by LC-MS-based metabolomics [0.03%]
基于LC-MS的代谢组学发现潜在女性特异性抑郁症生物标志物
Yi Wang,Dongcao Xu,Xinxin Liu et al.
Yi Wang et al.
The prevalence of major depressive disorder (MDD) is higher in females than males, emphasizing the need to identify gender-specific biomarkers to improve diagnosis accuracy. In this study, a cross-sectional investigation with 258 samples wa...
Comparative analysis of various senescence inducers in proximal renal tubular cells [0.03%]
不同衰老诱导剂对近端肾小管细胞的作用机制比较研究分析
Piyaporn Rattananinsruang,Chadanat Noonin,Visith Thongboonkerd
Piyaporn Rattananinsruang
Senescence in renal cells has attracted wide attention as the critical factor promoting renal fibrosis and chronic kidney disease. Establishing a reliable cellular model is essential to study mechanisms underlying renal cell senescence. Her...
Portable Raman spectroscopy and fourier transform near infrared spectroscopy for the quantification of different sinomenine hydrochloride crystal forms [0.03%]
便携式拉曼光谱和傅里叶变换近红外光谱定量不同氯化辛可宁盐晶型研究
Zehua Ying,Zixuan Yan,Xuting Guo et al.
Zehua Ying et al.
The objective of this paper is to rapidly and accurately quantify the content of the dominant crystal form of Sinomenine hydrochloride (SH) and to evaluate the respective characteristics of Raman spectroscopy and Fourier transform near infr...
Probe electrospray ionization coupled to a quadrupole time-Of-flight: A feasibility study for the detection of cocaine and its derivatives in oral fluid [0.03%]
探针电喷雾离子化与四级杆飞行时间联用法检测口腔液体中可卡因及其衍生物的可行性研究
Elisa Jousselin,Elies Zarrouk,Pauline Griffeuille et al.
Elisa Jousselin et al.
Probe Electrospray Ionization (PESI) is an atmospheric pressure ionization method that can be directly coupled with a mass spectrometer to allow ultrafast analyses without chromatographic separation and with minimal sample preparation. Usin...
Development and validation of an analytical method for the simultaneous quantitation of posaconazole Form I and Form-S in oral suspensions [0.03%]
新型口服悬液中泊沙康唑一型和S型定量分析方法的开发与验证研究
Michail Lykouras,Christos Kontoyannis,Malvina Orkoula
Michail Lykouras
Any polymorphic conversion of an active pharmaceutical ingredient (API), even if partial, is likely to lead to changes in its efficiency and safety. Posaconazole, an antifungal drug, is detected as Form-S in the commercially available oral ...
Rapid and simple fluorescent detection of chlorogenic acid in Aidi injection using aggregation-induced emission (AIE) nanoclusters [0.03%]
基于聚集诱导发光(AIE)纳米团簇快速检测艾迪注射液中的绿原酸
Pengwei Zhao,Zhixuan Song,Yunhan Li et al.
Pengwei Zhao et al.
Chlorogenic acid (CGA) is a key component in Aidi injection, known for its anti-cancer properties and ability to reduce toxicity. Therefore, accurate detection of CGA levels in Aidi injection is essential for monitoring therapeutic efficacy...
Brewer's spent grain as a potential sorbent for toxicology methods: Application to antidepressant analysis in urine [0.03%]
啤酒豆粕作为毒理学方法潜在吸附剂的应用：用于尿液中抗抑郁药分析的研究
Letícia Birk,Bruno Pereira Dos Santos,Daniela Souza Ossanes et al.
Letícia Birk et al.
The use of antidepressants is well-documented for several health conditions. The determination of these drugs in biological fluids is often important in intoxication cases. However, appropriate sample preparation needs to be employed, such ...