Fecal metabolic biomarkers associated with insomnia severity: A study on 5-hydroxyindoleacetic acid, octopamine, oleoylethanolamide, and elaidic acid [0.03%]
与失眠严重程度相关的粪便代谢生物标志物：5-羟基吲哚乙酸、八胺、油醇乙醇酰胺和反式油酸的研究
Yinuo Wu,Xiaoli Li,Haixia Feng et al.
Yinuo Wu et al.
Insomnia is increasingly recognized as a disorder with complex metabolic underpinnings. We investigated the changes in fecal metabolite levels of 5-hydroxyindoleacetic acid (5-HIAA), octopamine (OA), oleoylethanolamide (OEA), and elaidic ac...
Detection and localization of single-nucleotide mutations in synthetic oligonucleotides by ultra-high-performance liquid chromatography coupled with high-resolution tandem mass spectrometry [0.03%]
超高灵敏度的寡核苷酸单碱基突变检测及定位新技术
Mohamed A Gab-Allah,Hyojin Hwang,Mingyu Kim et al.
Mohamed A Gab-Allah et al.
Accurate detection of point mutations in mitochondrial DNA (mtDNA) is crucial for diagnosing various mitochondrial disorders. In this study, we developed an ultra-high-performance liquid chromatography coupled with high-resolution tandem ma...
Development and validation of an UPLC-MS/MS method for simultaneous determination of meropenem and its open-ring metabolite in human serum and cerebrospinal fluid with application to clinical samples [0.03%]
人血清和脑脊液中美罗培南及其开环代谢物的UPLC-MS/MS测定法的建立与验证及在临床样本中的应用
XiangLong Chen,Jinhui Xu,Chengliang Wang et al.
XiangLong Chen et al.
Central nervous system (CNS) infections require adequate drug exposure at the site of action, yet antibiotic meropenem (MER) shows limited cerebrospinal fluid (CSF) penetration and easily undergoes non-enzymatic degradation to an inactive o...
Cost-effective routine pharmaceutical testing using radial flow stream splitting HPLC columns: Quantitative analysis and performance metrics in the analysis of over-the-counter drugs [0.03%]
低成本的常规药物测试使用径向流动分流HPLC柱：非处方药分析中的定量分析和性能指标
Michalina McDermott,Zachary Sargeant,Christopher E Karlsen et al.
Michalina McDermott et al.
The demand for rapid and reliable analytical methods in the pharmaceutical industry continues to grow, with Ultra-/High-Performance Liquid Chromatography (U/HPLC) remaining the gold standard for impurity profiling, quantification of active ...
Sequential digestions enable identification and quantification of rapid aspartic acid isomerization in the CDR of a monoclonal antibody light chain [0.03%]
连续消化可使抗体轻链可变区内快速发生天冬氨酸异构化的鉴定与定量
Jérôme Jonveaux,Marc Faudon,Pauline Heymes et al.
Jérôme Jonveaux et al.
Isomerization of aspartic acid (Asp) to isoaspartic acid (isoAsp) within the complementarity-determining regions (CDRs) of monoclonal antibodies (mAbs) can lead to conformational changes that decrease antigen-binding affinity. Although isom...
Corrigendum to 'A liquid biopsy-RNAseq method for monitoring the expression of genes involved in drug disposition: proof-of-concept application to cholestatic liver disease' [J. Pharm. Biomed. Anal. (2025) 269: 117244] [0.03%]
关于“一种用于监测参与药物处置的基因表达的液体活检-RNAseq方法：在胆汁淤积性肝病中的概念验证应用”的勘误修正论文
Amit Dahal,Teresa Sierra,Colleen M Hayes et al.
Amit Dahal et al.
Comprehensive pharmacokinetic and tissue distribution study of α,ω-dipropionic acid polyethylene glycol (PA-PEG₁₂-PA) in rats using a validated UPLC-MS/MS method [0.03%]
基于UPLC-MS/MS验证方法的α, ω-二丙酸聚乙二醇（PA-PEG₁₂-PA）在大鼠体内综合药代动力学及组织分布研究
Meichen Liu,Yalin Yu,Yifei Jing et al.
Meichen Liu et al.
While polyethylene glycol (PEG) is an extensively utilized pharmaceutical polymer with established biocompatibility and regulatory acceptance, the in vivo pharmacokinetics of its bifunctional derivatives, such as α,ω-dipropionic acid poly...
Chemical profiling and multi-dimensional pharmacokinetic analysis of shengmaiyin oral liquid for cardiac dysfunction [0.03%]
用于心血管功能不全的生脉饮口服液的质量化学及多维药代动力学研究
Lifeng Zhao,Siyang Wu,Xin Yu et al.
Lifeng Zhao et al.
Shengmaiyin oral liquid (SMY), formulated with schisandra chinensis, red ginseng, and Ophiopogon japonicus, is widely used for treating cardiac dysfunction (CD). However, its functional chemical basis and pharmacological profiles remain ins...
The discovery of pharmacodynamic material basis and mechanism of Shuganning injection in treating damp-heat jaundice syndrome: Combining metabolomics and serum pharmacochemistry [0.03%]
疏肝宁注射液治疗湿热黄疸证的药效物质基础及机制研究：基于代谢组学和血清药物化学的结合分析
Yanmei He,Xiao Lin,Wanwan Zhong et al.
Yanmei He et al.
Shuganning injection (SGNI) is derived from Yinchenhao decoction and has the functions of promoting diuresis, reducing jaundice and protecting the liver. It is primarily utilized in the treatment of liver diseases, particularly damp-heat ja...
The mechanism of acetyl-L-carnitine on colorectal cancer and its metabolomic study [0.03%]
乙酰左卡尼汀调控结直肠癌的作用机制及其代谢组学研究
Jiayu Ning,Cuixin Cai,Xingxing Fan et al.
Jiayu Ning et al.
Colorectal cancer (CRC) is a prevalent malignancy worldwide, with increasing incidence and mortality rates. Acetyl-L-carnitine (ALC), a natural form of L-carnitine, possesses anti-inflammatory, free radical-scavenging, and mitochondrial mem...