Development of an LC-MS/MS method for the simultaneous quantification of 11 perfluoroalkyl compounds in mouse plasma for toxicokinetic applications [0.03%]
用于毒代动力学应用的小鼠血浆中11种全氟烷基化合物的同时定量的LC-MS/MS方法的开发
Chloé Ml Argoul,Yannick Dauwe,Laïla Lakhal et al.
Chloé Ml Argoul et al.
Following regulatory pressure, the manufacture of long-chain per- and polyfluoroalkyl substances (PFAS) has been phased out, and alternatives such as short-chain homologs and ether-PFAS have replaced the bioaccumulative long-chain PFAS. How...
Dual recombinase polymerase amplification system combined with lateral flow immunoassay for simultaneous detection of Staphylococcus aureus and Vibrio parahaemolyticus [0.03%]
基于重组酶聚合酶扩增技术的双重病原菌检测试纸条的研究与应用
Yan Zhang,Xiaofeng Liu,Jiawei Luo et al.
Yan Zhang et al.
Development of a highly sensitive visualization platform for multiplex genetic detection could significantly improve efficiency and reliability of on-site detection of foodborne pathogens. In this study, coupling recombinase polymerase ampl...
Application of bifunctional monomer surface MIP with MOFs nanocomposite for efficient trapping and analysis of luteolin in compound Anoectochilus roxburghii (Wall.) Lindl. oral liquid [0.03%]
双功能单体表面分子lynotein@MOFs纳米复合材料在复方石斛口服液中龙胆素的制备及测定中的应用研究
Qiuhua Zhang,Youjia Wu,Pingping Wu et al.
Qiuhua Zhang et al.
Luteolin is one of the bioactive components from the compound Anoectochilus roxburghii (Wall.) Lindl. oral liquid (CAROL), which was reported to have excellent hepatoprotective and anti-inflammatory activities. However, the enrichment and q...
Application of a dual channel MPTS-modified two-dimensional cell membrane chromatography system for rapid screening of effective ingredients in Saposhnikovia divaricata targeting inflammatory macrophages and fibroblast synovial cells in the treatment of rheumatoid arthritis [0.03%]
当归切片中针对炎症性滑膜成纤维细胞及巨噬细胞的抗风湿药效物质筛查分离及鉴定研究
Yueyue Li,Yanqiu Gu,Yuhuan Shi et al.
Yueyue Li et al.
Saposhnikovia divaricata (SD) is a traditional Chinese medicine (TCM) which has been commonly used for the treatment of rheumatoid arthritis (RA). However, its active components and mechanism of anti-RA are still unclear. Targeting rheumato...
Identification and pharmacological properties of 2-(1H-indazole-3-carboxamido)-3,3-dimethylbutanoate (MDMB-INACA), N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1H-indazole-3-carboxamide (ADB-INACA), and N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-hexyl-1H-indazole-3-carboxamide (ADB-HINACA) [0.03%]
MDMB-INACA、ADB-INACA和ADB-HINACA的鉴定及其药理性质研究
Fangqi Cao,Shuchen Yu,Xiujuan Chen et al.
Fangqi Cao et al.
Synthetic cannabinoids (SCs) are an evolving class of new psychoactive substances (NPS) with structurally various compounds that are increasing over the past few years. Therefore, they are initially hard to identify because of the lack of a...
Three sample preparation methods for clinical determination of CDK4/6 inhibitors with endocrine therapy in breast cancer patient plasma using LC-MS: Cross-validation (red), ecological (green) and economical (blue) assessment [0.03%]
乳腺癌患者血浆中CDK4/6抑制剂与内分泌治疗临床测定的三种样品前处理方法：对比验证（红色）、生态（绿色）和经济（蓝色）评估
Lu Turković,Zvonimir Mlinarić,Mila Lovrić et al.
Lu Turković et al.
Cyclin D-dependent kinase 4/6 inhibitors palbociclib, ribociclib and abemaciclib, in combination with aromatase inhibitors anastrozole and letrozole or oestrogen receptor degrader fulvestrant, are being assessed as candidates for therapeuti...
A multi-band spectral data fusion method for improving the accuracy of quantitative spectral analysis [0.03%]
一种提高定量光谱分析精度的多带光谱数据融合方法
Ling Lin,Shuo Wang,Kang Wang et al.
Ling Lin et al.
The signal-to-noise ratio of the spectrum is a critical determinant of detection accuracy in compositional analysis utilizing spectroscopy. The spectral data acquired by the spectrometer, while intended to capture essential sample character...
Feasibility of a direct binding electrochemiluminescence assay to detect anti-drug antibodies against therapeutic peptides [0.03%]
针对治疗性肽药物直接结合的电化学发光法检测抗药物抗体的可行性研究
Ruoxuan Sun,Janey Ronxhi,Xuemei Yang et al.
Ruoxuan Sun et al.
The emergence of anti-drug antibodies (ADAs) poses significant impacts on the bioactivity and toxicity of biotherapeutics including proteins and peptides. Developing reliable assays to monitor the magnitudes of ADAs in blood samples is ther...
Proteomics exploration of metformin hydrochloride for diabetic kidney disease treatment via the butanoate metabolism pathway [0.03%]
氯化二甲双胍治疗糖尿病肾脏疾病的丁酸代谢通路蛋白质组学研究
Jinxuan Chai,Yan Wang,Sifan Guo et al.
Jinxuan Chai et al.
Diabetic nephropathy (DKD) is a diabetesrelated kidney injury with an increasing incidence every year. Metformin hydrochloride (MET), a cornerstone treatment for glucose lowering, has been widely reported for the treatment of DKD, but the s...
Preparation of amyloid N-terminal nonapeptide imprinted monolithic column and evaluation of adsorption properties [0.03%]
β-淀粉样肽N端九肽印迹整体柱的制备及吸附性能评价
Zehui Wei,Wenxin Liu,Jun Zhang et al.
Zehui Wei et al.
A novel β-amyloid protein capillary microextraction column was designed and prepared using epitope molecular imprinting technology for specific recognition of trace β-amyloid proteins in complex biological matrices. Using N-terminal nonap...