Metabolic characteristics of prostate cancer cells with high metastatic potential revealed by (S)-ethyl 1-(3-(4-chlorophenoxy)-2-hydroxypropyl)-3-(4-methoxyphenyl)-1H-pyrazole-5-carboxylate inhibition [0.03%]
(S)-乙基-1-(3-(4-氯苯氧基)-2-羟基丙基)-3-(4-甲氧基苯基)-1H-吡唑-5-羧酸酯抑制高转移性前列腺癌细胞的代谢特征
Baoyan Ding,Wei Meng,Xiaoling Zang et al.
Baoyan Ding et al.
A small molecule, (S)-ethyl 1-(3-(4-chlorophenoxy)-2-hydroxypropyl)-3-(4-methoxyphenyl)-1H-pyrazole-5-carboxylate (SEC), has been reported to be capable of suppressing metastasis of prostate cancer (PCa) cells. In this study, SEC was used t...
Integrated network pharmacology, mass cytometry and multi-omics analysis the effect of Jingfang granule on intestinal immune disorder in mice with cold-dampness syndrome [0.03%]
基于网络药理学、流式细胞术及多组学分析荆防颗粒干预寒湿证小鼠肠免疫紊乱的作用机制研究
Shirong Li,Mingfei Liu,Lihong Pan et al.
Shirong Li et al.
The pathogenesis of cold-dampness syndrome (CDS) is closely related to intestinal inflammation and immune disorders induced by cold-dampness pathogen. CDS is the root cause of a variety of chronic inflammatory and immune diseases. Jingfang ...
Unsaturated fatty acid profiles and prognostic significance in epilepsy patients: A comprehensive analysis using UPLC-MS/MS and SVM algorithm [0.03%]
癫痫患者的不饱和脂肪酸谱型及预后意义的全面分析研究——UPLC-MS/MS和SVM算法联合应用
Xiuwei Shen,Jiaying Wu,Tao Zhou et al.
Xiuwei Shen et al.
Unsaturated fatty acids (UFAs) play a crucial physiological role in human body. However, the concentration-related changes and prognostic significance of UFAs in epilepsyremain unclear. An optimized ultra-performance liquid chromatography-t...
Dynamic profiling of intra- and extra-cellular L/D-amino acids metabolism in colorectal cell and intestinal epithelial cell [0.03%]
结肠癌细胞和肠道上皮细胞内镜内外氨基酸代谢的动态分析
Wenchan Deng,Rongrong Huang,Yuanjiang Pan et al.
Wenchan Deng et al.
The metabolism process of amino acids is closely related to the growth of normal and cancer cells. It is still not clear how L/D-configuration amino acids participate in the metabolism of colorectal cell. Herein, intra- and extra-cellular m...
Development and validation of a liquid chromatography-tandem mass spectrometry assay for the simultaneous analysis of isoniazid and pyrazinamide in cerebrospinal fluid [0.03%]
脑脊液中异烟肼和吡嗪酰胺同时分析的液相色谱-串联质谱测定法的开发与验证
Sydwell Poulo Maputla,Anton Joubert,Sandra Castel et al.
Sydwell Poulo Maputla et al.
For the effective treatment of tuberculosis with first-line anti-tubercular drugs, drug concentrations need to be measured at the site of infection to determine drug exposure. To enable the measurement of the anti-tuberculosis drugs isoniaz...
Deeper insights into the stability of oxylipins in human plasma across multiple freeze-thaw cycles and storage conditions [0.03%]
人 plasma 样本多次冻融及不同储存条件对氧脂素稳定性的影响研究
Maria Moran-Garrido,Sandra M Camunas-Alberca,Jorge Sáiz et al.
Maria Moran-Garrido et al.
Oxylipins are signaling lipids derived from the oxidation of polyunsaturated fatty acids (PUFAs). In lipidomic studies, human plasma may be subjected to various storage conditions and freeze-thaw cycles, which may impact the analysis of the...
Lipidomic profiling of the febrile rat hypothalamus by the intervention of Artemisia japonica extracts [0.03%]
干预药用植物日本蒿素对发热大鼠下丘脑脂质组的影响分析
Xiaodong Zhang,Suqing Zhao,Yuxue Ma et al.
Xiaodong Zhang et al.
Artemisia species have been regarded as an important source of ethnic medicinal plants, such as A. annua and A. capillaris, both of which are widely used in clinical treatment. The clinical efficacy of A. japonica is similar to that of A. c...
LAP-MALDI MS analysis of amelogenin from teeth for biological sex estimation [0.03%]
用于性别鉴定的牙齿釉灵蛋白的LAP-MALDI质谱分析研究
Lily R Adair,Mary E Lewis,Matthew J Collins et al.
Lily R Adair et al.
The biological sex estimation of human individuals can be achieved by extracting fragments of the amelogenin protein from small areas of tooth enamel. The amelogenin gene can be found on both sex chromosomes (X and Y) with chromosome-specif...
High throughput bioanalysis of serum 7a-hydroxy-4-cholesten-3-one (C4) using LC-MS/MS: Devising an end-to-end single vial solution for a sample limited application [0.03%]
一种用于样本有限情况下的高通量生物分析方法：使用LC-MS/MS分析血清中的7α-羟基-4-胆固烯-3-酮(C4)，仅需一管样完成实验从头到尾的过程
Soumya Kandi,Sarah Blink Polakow,John P Savaryn et al.
Soumya Kandi et al.
Crohn's disease (CD) is characterized by chronic ileal/ileocolonic inflammation, and in some cases, can result in bile acid malabsorption (BAM) and subsequent bile acid diarrhea (BAD). Although BAD is common in CD, diagnosis is difficult. I...
Biodegradability of dietary supplements: Advanced analytical methods to study the environmental fate of artificial sweeteners and dyes [0.03%]
膳食补充剂的生物降解性：研究人造甜味剂和染料环境命运的先进分析方法
Luisa Mattoli,Giada Fodaroni,Giacomo Proietti et al.
Luisa Mattoli et al.
Artificial sweeteners (ASs) and dyes are widely used in foods, beverages and pharmaceutical and are recognized as emerging environmental contaminants due to their persistence and widespread occurrence. These substances often pass through th...