Biotransformation analysis of daidzin in vitro based on fecal bacteria and probiotics [0.03%]
基于粪便菌群和益生菌的染料木素体外代谢研究分析
Yuqing Wang,Zhe Li,Dongxue Wu et al.
Yuqing Wang et al.
Daidzin, as one of isoflavone glycosides, has been reported to have multiple activities with few absorbed into body. However, the metabolic behavior of daidzin by intestinal flora has not been researched, that this defect severely constrain...
Identification and quality control of isomers in Huo-Xiang-Zheng-Qi Mixture using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry and inductive effects analysis [0.03%]
基于诱导效应分析的藿香正气合剂异构体的识别与质量控制-赵锋；侴万营；侴石磊；侴程远；侴发洋；侴金鹏；侴明月；侴铭浩；侴家琪；侴雨桐；侴雨轩
Yourun Chen,Chongyang Wang,Kaiwen Zhang et al.
Yourun Chen et al.
Huo-Xiang-Zheng-Qi Mixture is a renowned traditional Chinese medicine formula used to treat ailments associated with dampness pathogens. This study employed ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight...
Plasma bile acid profile analysis by liquid chromatography-tandem mass spectrometry and its application in healthy subjects and IBD patients [0.03%]
高效液相色谱-串联质谱法检测血浆游离胆汁酸并初步应用于健康人和IBD患者中
Xuepeng Gong,Dong Liu,Lu Liu et al.
Xuepeng Gong et al.
Bile acids (BAs), not only promote the absorption of fat-soluble nutrients and regulate the metabolism of multiple substances but also have a potential role as diagnostic and prognostic indicators in a variety of diseases such as cholestasi...
Evaluation study of congelex laxative granules based on HPLC fingerprint, multi-component content determination, and chemometrics [0.03%]
基于HPLC指纹图谱、多成分含量测定及化学计量学的肠乐颗粒质量评价研究
Chengjialu Qian,Shizhao Wang,Hongyan Chen
Chengjialu Qian
Congelex Laxative Granules is an in-house preparation of Hebei Provincial Hospital of Traditional Chinese Medicine. This study aims to establish the HPLC fingerprint of Congelex Laxative Granules and evaluate its quality using chemometric m...
Dispersive microextraction techniques as efficient strategies for the analysis of saliva: A comprehensive review [0.03%]
高效提取技术在唾液分析中的应用：综述
Andreu L López-Juan,Luis Miguel Moreno-Calleja,Juan L Benedé et al.
Andreu L López-Juan et al.
This review article brings together two of the current hot-spots in the field of analytical chemistry, and more specifically in the sample preparation stage: the use of dispersive microextraction techniques, and the analysis of saliva. Due ...
Comprehensive pharmacokinetic profiling of twelve compounds from Phellinus Igniarius extract in rats by UHPLC-MS/MS [0.03%]
高效液相色谱-质谱法测定灰黄孢层孔菌提取物中12种化合物在大鼠体内的药代动力学参数
Peng Zhao,Caixia Li,Shuting Zhou et al.
Peng Zhao et al.
The medicinal fungus Phellinus Igniarius (P. igniarius) has been demonstrated to possess a variety of pharmacological effects, including anti-oxidant, anti-tumor, blood circulation promotion, anti-diarrheal and sedative properties, etc. In ...
Strategies for automated affinity purification-resin screening for non-traditional biopharmaceuticals in the discovery space [0.03%]
发现空间中用于非传统生物制药的自动化亲和纯化树脂筛选策略
Jordan R Cave,Alexey A Makarov,Gregory F Pirrone
Jordan R Cave
Biotherapeutics occupy a significant portion of the pharmaceutical pipeline and are projected to continue growing in sales and scope. Further, the field is advancing novel and more complex molecules beyond monoclonal antibodies including mu...
Investigation of metabolite profiles of kidney tissues in rats treated with favipiravir drug: An NMR-based metabolomics study [0.03%]
基于核磁共振代谢组学的法匹拉韦药物致大鼠肾脏损伤的代谢轮廓研究
Zeynep Rozerin Çevik,Ali Erdoğan,Akın Mumcu et al.
Zeynep Rozerin Çevik et al.
In response to the urgent need for effective treatments during the rapid spread and high mortality rate of COVID-19, existing drugs were repurposed for potential antiviral effects, including favipiravir, originally designed as an RNA-depend...
Plasma metabolomic signatures after oral administration of ritonavir in COVID-19 treatment via chemometrics-assisted UPLC/Q-TOF/MS/MS [0.03%]
基于化学计量学辅助UPLC/Q-TOF/MS/MS分析的口服利托那韦治疗新冠肺炎后血浆代谢标志物的变化特征研究
Fatma Demirkaya Miloglu,Burak Bayrak,Busra Yuksel et al.
Fatma Demirkaya Miloglu et al.
Understanding the pharmacodynamics of ritonavir through metabolomics offers insights into its side effects and helps in the development of safer therapies. This study aimed to investigate the effects of ritonavir treatment on the metabolic ...
Saba Jorbenadze,Giorgia Sprega,Aluda Chelidze et al.
Saba Jorbenadze et al.
N-(3-hydroxyacyl)glycines are compounds of remarkable interest due to their biogenic origin and bioactivity and as precursors of the corresponding 3-acyloxy derivatives which represent an important class of bioactive products of bacterial o...