Acquisition and transcriptomic analysis of tissue micro-regions using a capillary-based method [0.03%]
基于毛细管的方法获取并分析组织微区域的转录组信息
Kaiqiang Ye,Yunxia Guo,Ying Wang et al.
Kaiqiang Ye et al.
Profiling the site-specific transcriptomes of microregions of interest (mROIs) contributes to a complete understanding of multicellular organisms. However, the simple and efficient isolation of mROIs for spatially detecting gene expression ...
Identification of anti-SARS-CoV-2 compounds from Qingwen Zhike prescription and exploration of their underlying mechanism by UPLC-Q-Exactive Orbitrap MS, high-throughput screening assays and transmission electron microscopy [0.03%]
基于UPLC-Q-Exactive Orbitrap MS、高通量筛选试验和透射电子显微镜技术的新冠肺炎治疗方剂“清瘟解毒颗粒”抗SARS-CoV-2成分及机制研究
Ping Zhao,Cai Zhang,Yue Che et al.
Ping Zhao et al.
Qingwen Zhike prescription (QWZK), a traditional Chinese medicine (TCM) hospital prescription developed in response to the corona virus disease 2019 (COVID-19) pandemic, has demonstrated efficacy in clinical practice. Nevertheless, its spec...
Untargeted metabolomics combined with lipidomics revealed the effects of myocardial infarction and exercise rehabilitation on blood circulation metabolism of patients based on liquid chromatography-mass spectrometry [0.03%]
基于液相色谱质谱的未靶向代谢组学结合脂质组学分析心梗患者冠心病康复对血液循环代谢影响
Na Wang,Huimin Li,Hao Wu et al.
Na Wang et al.
Myocardial infarction (MI) is a major cause of death worldwide. Exercise rehabilitation (ER) is a powerful tool to improve life quality and prognosis of MI patients. Herein, we developed an untargeted metabolomics combined with lipidomics m...
An exploratory multi-omics study reveals distinct molecular signatures of ulcerative colitis and Crohn's disease and their correlation with disease activity [0.03%]
一项探索性的多组学研究揭示了溃疡性结肠炎和克罗恩病的不同分子特征及其与疾病活动度的相关性
Nguyen Tran Nam Tien,Eun Jeong Choi,Nguyen Quang Thu et al.
Nguyen Tran Nam Tien et al.
Clinically heterogeneous spectrum and molecular phenotypes of inflammatory bowel disease (IBD) remain to be comprehensively elucidated. This exploratory multi-omics study investigated the serum molecular profiles of Crohn's disease (CD) and...
Joint proteomic and metabolomic analysis reveals renal metabolic remodeling of chronic heart failure mice [0.03%]
联合蛋白质组及代谢组分析揭示慢性心力衰竭小鼠肾组织的代谢重塑
Chunliu Wang,Jie Zhou,Pu Jia et al.
Chunliu Wang et al.
Pharmacologic intervention in chronic heart failure (HF) with renal insufficiency is one of the clinical challenges due to the fact that the mechanisms of cardio-renal interactions in chronic heart failure (CHF) progressing have not been fu...
A complementary and integrated strategy for multicomponent characterization and attribution of Danning tablet based on convergence and liquid chromatography combined with mass spectrometry [0.03%]
基于汇聚和液相色谱与质谱联用的丹宁片多组分特征及归属的互补及整合策略研究
Yu Wang,Zhengcai Ju,Linnan Li et al.
Yu Wang et al.
Danning tablet (DNT) is a traditional Chinese medicine (TCM) that contains seven herbal ingredients. It has been clinically used to treat liver and gallbladder diseases in humans. However, the complex composition of TCM prescriptions makes ...
Metabolic and molecular basis of flavonoid biosynthesis in Lycii fructus: An integration of metabolomic and transcriptomic analysis [0.03%]
基于代谢组学和转录组学分析的枸杞中黄酮类化合物生物合成的代谢及分子基础研究
Limei Tong,Yinxiu Jiang,Xinrun Zhang et al.
Limei Tong et al.
Flavonoids serve as bioactive components and contribute to medicinal and nutritional profile of Lycii fructus. However, there is limited information regarding the influence of ecological environments on the flavonoid biosynthesis pathway. I...
Dried blood spot LC-MS/MS quantification of voclosporin in renal transplant recipients using volumetric dried blood spot sampling [0.03%]
用于肾脏移植受者的体积干燥血点采样量化测定伏西普利拉浓度的LC-MS/MS方法
E Metscher,S Meziyerh,E J Arends et al.
E Metscher et al.
Voclosporin is a potent immunosuppressive agent currently approved for treating active lupus nephritis. Based on its potential antiviral activity, it has also been investigated as immunosuppressive agent in an investigator-initiated study i...
Highly sensitive ultra-high-performance liquid chromatography coupled with tandem mass spectrometry method for the multiplex analysis of levosimendan and its metabolites OR-1855 and OR-1896 in human plasma [0.03%]
人血浆中左西孟丹及其代谢产物OR-1855和OR-1896的高灵敏度超高效液相色谱串联质谱多重分析方法
Stéphane Bertin,François Versace,Thomas Mercier et al.
Stéphane Bertin et al.
Levosimendan is a positive inotrope and vasodilator used in patients with acute and chronic decompensated heart failure. It is metabolized into OR-1855 (inactive metabolite), which is further acetylated into OR-1896 (active metabolite havin...
Advancements in glycan analysis: high performance anion exchange chromatography-pulsed amprometric detection coupled with mass spectrometry for structural elucidation [0.03%]
糖类分析的新进展：高效能阴离子交换层析-脉冲安培检测与质谱联用技术的结构解析研究
Lin Yi,Yuxia Luo,Siqi Yang et al.
Lin Yi et al.
Carbohydrates are essential biomolecules that play a vital role in various biological processes across humans, plants, and bacteria. Despite their ubiquity, the structural elucidation of carbohydrates, particularly oligo- and polysaccharide...