Characterization of main degradation products from dendrobine under stress conditions by multistage cleavage of UPLC-ESI-IT-TOF [0.03%]
应力条件下石斛碱主要降解产物的多级裂解UPLC-ESI-IT-TOF质谱鉴定
Hengju Zhou,Meiling Zeng,Keyong Geng et al.
Hengju Zhou et al.
Dendrobine is a sesquiterpene alkaloid primarily used in the treatment of inflammatory diseases, immune system disorders, and conditions related to oxidative stress. To understand the possible degradation pathways of dendrobine for its qual...
Implementation of a novel method for the determination of plasma protein binding of highly bound compounds using the equilibrium dialysis method coupled with extraction to the organic phase and its comparison to known methods [0.03%]
一种新的利用平衡透析结合有机相萃取测定高血浆蛋白结合化合物的方法及其与已知方法的比较
Dawid Gogola,Sanja Novak Ratajczak,Ewelina Gabor-Worwa et al.
Dawid Gogola et al.
Accurate determination of plasma protein binding (PPB) is crucial in understanding the pharmacokinetics and pharmacodynamics of drugs, particularly for highly bound compounds where traditional methods may fall short. In this study, we prese...
Analysis of Pz-1, a promising therapeutic for organophosphorus poisoning from rodent plasma by liquid chromatography-tandem mass spectrometry [0.03%]
液相色谱-串联质谱分析鼠血浆中的新型有机磷中毒治疗药物Pz-1
Khadija Bilkis,Moustafa M R Khalaf,Darci M Fink et al.
Khadija Bilkis et al.
Organophosphorus (OP) pesticides (e.g., parathion) and nerve agents (e.g., soman) can produce acute and long-term neurological problems. Exposure to OP chemicals is responsible for an estimated 200,000 deaths annually. Pz-1 (N-(5-(tert buty...
Impact of sample heterogeneity on the evaluation of uncertainty from sampling and analytical steps in pharmaceutical analysis [0.03%]
样品异质性对药品分析中取样和检测不确定度评估的影响
Victória Aparecida Vit Crivilari,Jean Bispo Dos Santos,Felipe Rebello Lourenço
Victória Aparecida Vit Crivilari
Measurement uncertainty is a critical factor in the reliability of pharmaceutical analyses, since it directly affects batch acceptance and regulatory compliance. While analytical uncertainty has been extensively studied, uncertainty arising...
Equipmentless point-of-care testing of dengue antibodies using ELISA and smartphones [0.03%]
基于ELISA和智能手机的无需设备登革热抗体床旁检测技术
Diego Mendicino,Christian Avalos,Romina Chiaraviglio et al.
Diego Mendicino et al.
Infections with the dengue virus affect more than 100 million people every year. The infected can present a mild form of the disease or a severe form, which can, eventually, lead to death. Dengue prevails in tropical and subtropical regions...
Development and validation of an LC-MS/MS method for quantification of Osimertinib and its two metabolites AZ7550 and AZ5104 in human plasma including long-time storage [0.03%]
一种用于人体血浆中奥希替尼及其两种代谢物AZ7550和AZ5104长期储存定量分析的LC-MS/MS方法的开发与验证
Eva Greibe,Boe Sorensen,Peter Meldgaard et al.
Eva Greibe et al.
Osimertinib (AZD9291) is a widely used tyrosine kinase inhibitor for the treatment of non-small cell lung cancer patients with activating EGFR mutations. However, the correlation between dose and efficacy has been debated for several years....
A simple LC-MS/MS assay for the quantification of E6011, a novel anti-fractalkine monoclonal antibody, in cynomolgus monkey serum - comparison with ligand binding assay [0.03%]
一种简单LC-MS/MS测定法用于量化新型抗fractalkine单克隆抗体E6011的猴子血清分析与配体结合测定比较
Kenji Kita,Haruna Ono,Tomoko Kojima et al.
Kenji Kita et al.
E6011 is a monoclonal antibody that is currently under development for the treatment of rheumatoid arthritis. While ligand binding assays (LBAs) are typically employed for the determination of therapeutic antibodies, ultra-performance liqui...
Zeynep Özdemir,Selen Al,Aykut Kul et al.
Zeynep Özdemir et al.
Epilepsy is a major disease affecting millions of people worldwide. Carbamazepine is on the World Health Organization's list of essential medicines and is one of the most prescribed medicines for treating epilepsy. It has a narrow therapeut...
Development and validation of an UPLC-MS/MS method with polarity switching for simultaneous determination of 14 antiepileptic drugs and 2 metabolites in human serum [0.03%]
一种用于同时测定人血清中14种抗癫痫药物及其2种代谢产物的UPLC-MS/MS方法的开发与验证
Xiao-Han Peng,Yan-Lin Zhao,Zhong Huang et al.
Xiao-Han Peng et al.
Currently, treatment with antiepileptic drugs (AEDs) is still the first choice for epileptic patients, while monitoring their blood concentrations is undoubtedly beneficial for minimizing their adverse side effects and optimizing their ther...
A simple automated assay format for measuring multiple immune checkpoint inhibitors [0.03%]
一种用于测量多种免疫检查点抑制剂的简单自动化测定格式
Ragnhild V Nome,Øystein Flatebø,Sigurd Leinæs Bøe et al.
Ragnhild V Nome et al.
Immune checkpoint inhibitors (ICIs) have improved survival rates in oncology, but there is a rising concern for immune-related adverse health outcomes. Monitoring drug serum concentration would enable tailored dosing, however this strategy ...