Nano-zirconium-silicate solid-phase extraction method for the rapid quantification of pyrrolizidine alkaloids from plant extracts by UHPLC-QTOF-MS [0.03%]
纳米层析硅酸锆固相萃取超高压液相色谱-高分辨质谱法快速测定植物中吡咯里西啶生物碱含量
Benedikt Schwarz,Shah Hussain,Christian W Huck et al.
Benedikt Schwarz et al.
The aim of this work was to develop and validate a rapid dispersive-solid-phase extraction method for the quantification of pyrrolizidine alkaloids (PA) from plant extracts. The method was focused on the significant removal of the intricate...
Rapid determination of etomidate and its structural analogues in e-liquid by probe electrospray ionization quadrupole time-of-flight mass spectrometry [0.03%]
基于探针电喷雾离子化四极杆飞行时间质谱的托吡酯及其结构类似物的快速检测方法研究
Meiting Lin,Zhen Zhang,Qun He et al.
Meiting Lin et al.
Etomidate and its structural analogues, which have anesthetic effects, are classified as controlled psychotropic drugs. Electronic cigarettes (e-cigarettes) have become more and more popular. With the increase of adding etomidate and its an...
Cellulose filter paper immobilized acetylcholinesterase for rapid screening of enzyme inhibitors in Phyllanthus emblica L [0.03%]
用石蜡固定滤纸结合的乙酰胆碱酯酶快速筛选木果素中酶抑制剂
Yangzom Dawa,Yong-Chen Hua,Fang-Di Hu et al.
Yangzom Dawa et al.
Acetylcholinesterase (AChE) is widely recognized as a promising therapeutic target enzyme for Alzheimer's disease (AD). The screening of AChE inhibitors (AChEIs) holds great significance for the treatment of AD. In this study, cellulose filte...
Chromatographic analysis and pKa evaluation of active pharmaceutical ingredients in anti-metastatic breast cancer: Green vs. conventional RPLC [0.03%]
高效液相色谱法在抗乳腺癌转移药物中的应用及活性成分pKa值的评价：绿色化学vs传统化学
Fatmanur Kalkir,Ebru Çubuk Demi Ralay,Yaşar Doğan Daldal et al.
Fatmanur Kalkir et al.
This study aimed to determine the chromatographic retention and dissociation/protonation constant (pKa) values of lapatinib and tamoxifen, key drugs used in metastatic breast cancer treatment, at 37°C using both conventional and green high...
Hydrophilic interaction liquid chromatography-tandem mass spectrometry analysis of oligosaccharides and iridoid glycosides in rat plasma: Pharmacokinetic characterization of previously overlooked oligosaccharides from Radix Rehmanniae [0.03%]
大鼠血浆中寡糖和环木脂内酯苷的亲水作用色谱-串联质谱分析： radix rehmanniae 中先前被忽略的寡糖的药代动力学特征化
Hanyang Wang,Yue Du,Chunwei Zhou et al.
Hanyang Wang et al.
Radix Rehmanniae (RR) is a widely used herb in traditional Chinese Medicine with properties of tonifying the kidneys and nourishing the blood. Both raw and processed RR are effective for the treatment of diabetes in clinical practice. Oligo...
A reliable LC-MS/MS method for the quantification of natural amino acids in human plasma and its application in clinic [0.03%]
一种人血浆中天然氨基酸定量的可靠LC-MS/MS方法及临床应用
Junhuan Lin,Yibo Song,Yangrui Zhang et al.
Junhuan Lin et al.
A simple and fast LC-MS/MS method was developed and validated for simultaneous quantification of 20 L-amino acids (AAs) in human plasma. Chromatographic separation was achieved on an Agilent AdvanceBio Hilic column within 15 min via gradien...
Investigation and elimination of noncovalent artificial aggregates during non-reduced capillary electrophoresis-sodium dodecyl sulfate analysis of a multi-specific antibody [0.03%]
非还原毛细管电泳-十二烷基硫酸钠分析多特异抗体时非共价人工聚集体的检测与消除
Jianhui Cheng,Qianchuan Lv,Yuanzhao Ji et al.
Jianhui Cheng et al.
Capillary electrophoresis-sodium dodecyl sulfate (CE-SDS) is widely used in the biopharmaceutical industry for monitoring purity and analyzing impurities. The accuracy of the method may be compromised by artificial species resulting from sa...
Differentiation of the chronic lymphocytic leukemia response to ibrutinib and acalabrutinib treatment by single-cell MALDI-TOF MS imaging [0.03%]
基于单细胞基质辅助激光解析电离飞行时间质谱成像的慢性淋巴细胞白血病对Ibrutinib和Acalabrutinib治疗反应的区分方法研究
Ivana Marković,Iva Lukić,Maja Lukić et al.
Ivana Marković et al.
Ibrutinib and acalabrutinib, Bruton's tyrosine kinase inhibitors (BTKi) used for chronic lymphocytic leukemia (CLL) treatment, aim the same target but their off-target effects are different. The aim of this study was to use single-cell MALD...
Research on the metabolites and key metabolic enzymes of allocryptopine in chicken liver microsomes via stable isotope tracing technology [0.03%]
稳定同位素示踪技术结合鸡肝微粒体代谢试验对 Allocryptopine 代谢产物及关键代谢酶的研究
Zhiyong Wu,Xinhao Wang,Lin Wang et al.
Zhiyong Wu et al.
Allocryptopine (ALL), a principal active component of the novel veterinary medicine Bopu Powder®, has gained widespread application in the poultry farming sector for the effective management of Escherichia coli (E. coli) diarrhea. In order...
Whole-cell aptamer-based techniques for rapid bacterial detection: Alternatives to traditional methods [0.03%]
用于快速细菌检测的全细胞适配子技术：传统方法的替代品
Juliette Nourry,Pauline Chevalier,Emmanuelle Laurenceau et al.
Juliette Nourry et al.
Controlling the spread of bacterial infectious diseases is a major public health issue, particularly in view of the pandemic of bacterial resistance to antibiotics. In this context, the detection and identification of pathogenic bacteria is...