Trametes robiniophila Murr. extract alleviates influenza-induced lung injury by regulating gut microbiota and metabolites [0.03%]
罗布氏孔菌提取物通过调节肠道微生物群和代谢产物缓解流感引起的肺损伤
Jiyuan Cao,Yu Zhang,Yingnan Jiang et al.
Jiyuan Cao et al.
Trametes robiniophila Murr. (Huaier) is a traditional medicinal fungus known for its pharmacological properties, including heat-clearing, detoxifying, anti-inflammatory, and antitumor effects. Our previous research has demonstrated its anti...
Revealing the therapeutic targets, mechanisms, and heterogeneity of Huatan Jieyu Granules for Parkinson's disease through single-cell sequencing [0.03%]
通过单细胞测序揭示化痰解郁颗粒治疗帕金森病的靶点、机制及异质性
Sijia Zhu,Meijun Liu,Shiyu Han et al.
Sijia Zhu et al.
Background: The incidence of Parkinson's disease (PD) increases with age. Previous pharmacological studies have shown the potential of Huatan Jieyu Granules (HGs) for the treatment of PD, but the exact mechanisms remain u...
Simultaneous determination of busulfan, fludarabine, phenytoin, and posaconazole in plasma from patients undergoing hematopoietic stem cell transplantation [0.03%]
造血干细胞移植患者血浆中_busulfan_、_fludarabine_、_苯妥英_和_posaconazole_的同步测定法
Xijuan Jiang,Jia Liu,Xuan Feng et al.
Xijuan Jiang et al.
A simple, fast, sample-saving, and sensitive liquid chromatography-tandem mass spectrometry method was established with a linear range adjusted by in-source collision-induced dissociation. Notably, this could simultaneously determine busulf...
Gastrointestinal motility modulation efficacy-related chemical marker findings and QAMS-based quality control of Agastache rugosa [0.03%]
广藿香调节胃肠动力有效性化学标记物研究及质量控制基原植物鉴定方法学研究
Guo-Zhen Jiang,Zhen-Yue Ma,Hui-Dan Hou et al.
Guo-Zhen Jiang et al.
Agastache rugosa (AR), a traditional edible and medicinal herb, is often used for treating gastrointestinal (GI) motility disorder. But little effort has been done on its gastrointestinal motility modulation (GMM) efficacy-related component...
Chemometric tools to comprehend a recovery process for the bioactive ingredients from purple basil (Ocimum basilicum L.): Box-Behnken design-based optimization and principal component analysis [0.03%]
化学计量学工具用于理解紫罗兰香蜂草（Ocimum basilicum L.）中有益成分的提取过程：Box-Behnken设计优化和主成分分析
İrem Toprakçı,Ebru Kurtulbaş,Selin Şahin
İrem Toprakçı
Medicinal and aromatic plants are alternative products to synthetics because of their antioxidant, antimicrobial, anti-inflammatory and antidiabetic effects. The objective of this study is to investigate the automated solvent extraction (AS...
LC-MS/MS based analytical strategies for the detection of lipid peroxidation products in biological matrices [0.03%]
基于LC-MS/MS的生物基质脂质过氧化产物检测分析策略
Federico Fanti,Manuel Sergi,Dario Compagnone
Federico Fanti
Oxidative stress (OS) arises mainly from exposure to reactive oxygen species (ROS) such as superoxide anion, hydroxyl radical, and hydrogen peroxide. These molecules can cause significant damage to proteins, DNA, and lipids, leading to vari...
Peptide mapping analysis of synthetic semaglutide and liraglutide for generic development of drugs originating from recombinant DNA technology [0.03%]
重组DNA技术来源药物通用名开发中的肽图分析：索马鲁肽和利拉鲁肽的合成品与参比药的一致性研究方法学探讨
Soo Hyun Kim,Sung Soo Kim,Hyun Jun Kim et al.
Soo Hyun Kim et al.
Semaglutide and liraglutide are long-acting glucagon-like peptide-1 receptor agonists used to treat type-2 diabetes and obesity. Recent advances in peptide synthesis and analytical technologies have enabled the development of synthetic gene...
Quantification and clinical performance of serum parathyroid hormone 1-84 via immunocapture coupled to LC-MS/MS in chronic renal failure [0.03%]
免疫捕获结合LC-MS/MS测定慢性肾衰患者血清甲状旁腺激素1-84的含量及其临床意义
Haiwei Cao,Yuting Jin,Yingwu Wang et al.
Haiwei Cao et al.
Accurate measurement of serum parathyroid hormone (PTH) is crucial for diagnosing and managing endocrine and osteological diseases. Conventional immunoassay methods struggle with cross reactivity issues between full-length PTH and truncated...
Targeted and untargeted urinary metabolomics of alkaptonuria patients using ultra high-performance liquid chromatography-tandem mass spectrometry [0.03%]
应用超高效液相色谱-串联质谱技术进行尿黑酸病患者的目标及非目标代谢组分析
Kristian Serafimov,Johanna Ruth Tischlarik,Michael Lämmerhofer
Kristian Serafimov
Alkaptonuria (AKU) is a rare autosomal-recessive disease which is characterized through black urine and ochronosis. It is caused by deficiency of the enzyme Homogentisate 1,2-dioxygenase in the Phenylalanine/Tyrosine degradation pathway whi...
Ganoderma lucidum spore oil attenuates acute liver injury by modulating lipid metabolism and gut microbiota [0.03%]
灵芝孢子油通过调节脂质代谢和肠道菌群减轻急性肝损伤
Jianying Liu,Yan Chen,Zhifeng Cen et al.
Jianying Liu et al.
The incidence of acute liver injury is increasing and poses a significant threat to human health. Ganoderma lucidum spore oil (GLSO), a lipid substance extracted from Ganoderma lucidum spore powder using supercritical CO2 technology, has be...