PCN-224/β-Cyclodextrin dual-modified magnetic nanocomposite for efficient extraction and determination of nobiletin and tangeretin in Chenpi-based beverages [0.03%]
一种用于陈皮饮料中诺比酮和光柑橘素的高效提取及测定的PCN-224/β-环糊精双修饰磁性纳米复合材料
Renyan Liu,Linqi Su,Yu Zhang et al.
Renyan Liu et al.
Polymethoxylated flavonoids such as nobiletin and tangeretin are the primary bioactive constituents of Chenpi. However, their accurate quantification in complex beverage matrices remains challenging. In this study, a novel dual-modified mag...
Antiproliferative effects of pachymic acid on thyroid cancer cells and characterization of its metabolites [0.03%]
香菇酸对甲状腺癌细胞的抗增殖作用及其代谢产物的表征
Feng Wang,Jing Li,Bin Hu et al.
Feng Wang et al.
Thyroid cancer (THCA) is the most prevalent endocrine malignancy, underscoring the need for novel therapies. Pachymic acid (PA), a key bioactive triterpenoid from P. cocos, possesses documented anticancer activity, yet its role in thyroid c...
A rapid 2-minute LC-MS/MS method with simple protein precipitation for simultaneous determination of tryptophan and its two metabolites kynurenine and kynurenic acid in human serum [0.03%]
一种快速的两步LC-MS/MS方法（简单的蛋白质沉淀法）用于同时测定人血清中色氨酸及其两种代谢产物犬尿酸和夸伦酸的方法
Hui Yan,Haoyang Lu,Shanqing Huang et al.
Hui Yan et al.
Dysregulation of the tryptophan (TRP) metabolic pathway is closely linked to the pathophysiology of neuropsychiatric disorders, such as depression. This study aimed to develop and validate a sensitive, rapid, and robust liquid chromatograph...
Heterologous internal calibration for multiplexed internal quantification in targeted LC-MS/MS bioanalysis [0.03%]
异源内标法在靶向液质联用生物分析中的倍式内部定量应用
Oriane Strassel,Max Feinberg,Gioele Visconti et al.
Oriane Strassel et al.
Absolute quantification is crucial in bioanalysis for both clinical and non-clinical applications but remains challenging, especially for endogenous metabolites. In external calibration, the absence of a true blank matrix complicates calibr...
GC-MS method development and validation for the determination of Short Chain Fatty Acids in human feces [0.03%]
人体粪便中挥发性脂肪酸的气相色谱-质谱分析方法的建立及验证
Gkanali Vasiliki,Farantatou Konstantina,Begou Olga et al.
Gkanali Vasiliki et al.
Short Chain Fatty Acids (SCFAs), the end products of microbial fermentation of dietary fibers, appear to be key mediators of the beneficial effects elicited by the gut microbiome and have been shown to exert multiple effects on metabolism. ...
Methyl orange-enhanced DNA hybridization: A gene sensor approach for hepatitis delta detection [0.03%]
甲基橙增强型DNA杂交：一种用于检测丁型肝炎的基因传感器方法
Dayane D Moraes,Luiz F G Luz,Márcia M C N Soares et al.
Dayane D Moraes et al.
Hepatitis delta is an infection triggered by the hepatitis delta virus (HDV), a defective virus that requires the hepatitis B virus (HBV) to replicate. Coinfection with both viruses can result in more severe complications, including progres...
Sorbent-coated metal discs: A hybrid active/passive exhaled breath sampling alternative for early lung cancer screening [0.03%]
涂有吸附剂的金属盘：用于早期肺癌筛查的呼出气主动/被动联合采样方法
Robert Lundberg,Thomas Lundeberg,Jan Andrasko et al.
Robert Lundberg et al.
In this new breath sampling method, a metal disc with carbopack X sorbent was exposed to prolonged exhalation. Sampled volatile organic compounds (VOCs) were transferred to a solid phase micro-extraction (SPME) fiber for gas chromatography-...
A holistic strategy for the preparation and quality control of sugar-free Fufang Ciwujia granules: Comprehensive quality evaluation through fingerprint and QAMS [0.03%]
无糖复方刺五加颗粒制备及质量控制的系统策略研究——基于指纹图谱和QAMS的综合评价体系
Zhiyu Zhan,Zexuan Chen,Xueyee Lim et al.
Zhiyu Zhan et al.
Fufang Ciwujia granule (FCG), a herbal extract formulation effective for treating insomnia and dream-disturbed sleep, is limited for sugar-restricted populations due to its high sucrose content. Furthermore, its quality control (QC), relian...
Biosensor based on hybrid composite and Concanavalin a lectin for microorganisms differentiation [0.03%]
基于杂化复合材料和Concanavalin A的微生物鉴别型生物传感器
Alice M N Souza,Alberto G Silva-Junior,Maurilia P Costa et al.
Alice M N Souza et al.
For the treatment of candidemia, especially in critical care settings, rapid identification of Candida species remains essential. Hybrid compounds have emerged as a powerful strategy to address challenges in microbiological detection and co...
Development and validation of an online extraction HPLC-HRMS method for the quantification of carbapenems in FecalSwab™ samples [0.03%]
在线萃取HPLC-HRMS法测定FecalSwab样品中碳青霉烯类抗生素的方法建立及验证
Matthieu Holub,Assaf Mizrahi,Thibaut Genty et al.
Matthieu Holub et al.
Quantifying carbapenems in fecal samples is analytically challenging due to their instability and the complexity of intestinal matrices. We developed and validated a novel HPLC-HRMS method enabling direct quantification of imipenem and mero...