Aggregation-induced luminescence probe based lateral flow immunoassay for the simultaneous quantitative detection of IL-6/PCT [0.03%]
一种基于聚集诱导发光探针的侧向流动免疫层析试纸条同时定量检测IL-6和PCT的方法
Rong He,Yanjie Zhu,Weiping Zhou et al.
Rong He et al.
The detection of important inflammatory biomarkers possesses substantial advantages in guiding clinical decision-making. In particular, simultaneous detection of interleukin-6 (IL-6) and procalcitonin (PCT) significantly improves the differ...
Simultaneous determination of three phosphatidylethanol homologues, 12 drugs and metabolites in whole blood by LC-MS/MS [0.03%]
一种同时检测全血中三种磷脂乙醇同系物和12种药物及其代谢产物的LC-MS/MS方法
Marisa H Maria,Nuno R Neng,Thomas Berg
Marisa H Maria
The use of alcohol, legal and illicit substances poses great negative consequences on health and economy worldwide. LC-MS/MS allow simultaneous determination of multiple compounds in biological matrices. The aim of this study was to develop...
Identification of blood-absorbed components of Qingkui Yuyang decoction and its mechanistic roles in ulcerative colitis based on UPLC-Q-Exactive Orbitrap-MS/MS and network pharmacology [0.03%]
基于UPLC-Q-Exactive Orbitrap-MS和网络药理学研究清溃愈疡方的入血成分及其在溃疡性结肠炎中机制作用
Yunwang Chen,Long Liu,Yinting Wei et al.
Yunwang Chen et al.
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by recurrent episodes of intestinal inflammation and mucosal injury. Qingkui Yuyang decoction (QKY), a clinically validated traditional Chinese medicinal formula,...
Determination of Gentamicin C-subtypes in Inner Ear Perilymph Using Liquid Chromatography with Fluorescence Detection [0.03%]
应用荧光检测高效液相色谱法测定内耳围淋巴中庆大霉素C亚型
Shreshtha Dash,Molly T McDevitt,D David Smith et al.
Shreshtha Dash et al.
Gentamicin is a broad-spectrum aminoglycoside used frequently to treat gram-positive and gram-negative bacterial infections. In this study, a new, simple, fast, and sensitive isocratic reversed-phase high performance liquid chromatography (...
Temperature as the primary risk factor for sevoflurane degradation: Identification and toxicological risk assessment of novel degradants by nuclear magnetic resonance (NMR) spectroscopy [0.03%]
温度为主要的异氟烷降解风险因素：利用核磁共振(NMR)光谱鉴定新型降解产物并评估其毒性风险
Yi Jin,Yaning Li,Haoran Yang et al.
Yi Jin et al.
Sevoflurane is an inhalation anesthetic, which is widely favored by anesthesiologists in modern clinical practice. It is reported that sevoflurane readily degrades under certain conditions. Forced degradation studies are essential for eluci...
Three-dimensional high-performance liquid chromatographic determination of serine, threonine and allothreonine enantiomers in the d-amino acid oxidase deficient mice and rats [0.03%]
三维高效液相色谱法测定丝氨酸、苏氨酸和高苏氨酸对映体在d型氨基酸氧化酶缺陷小鼠和大鼠中的含量
Mai Oyaide,Takeyuki Akita,Chiharu Ishii et al.
Mai Oyaide et al.
The amounts of the serine (Ser), threonine (Thr) and allothreonine (aThr) enantiomers were determined in tissues (cerebrum, cerebellum, pancreas, liver and kidney) and physiological fluids (plasma and urine) of rats and mice with deficiency...
Development and validation of a sensitive and rapid UHPLC-MS/MS method for the simultaneous quantification of CG-0255 and its active metabolite in human plasma and its application to Phase I studies [0.03%]
一种灵敏快速的UHPLC-MS/MS法同时测定人体血浆中CG-0255及其活性代谢产物浓度的方法学建立及验证及其在I期临床试验中的应用
Hanjing Chen,Jiali Li,Fei Yuan et al.
Hanjing Chen et al.
CG-0255, a thiol prodrug of clopidogrel's active metabolite H4 (CG-0236), is a novel thienopyridine P2Y12 receptor antagonist under initial clinical development for the treatment of acute coronary syndromes. Unlike clopidogrel, CG-0255 is c...
A streamlined workflow for early phase formulation development of monoclonal antibodies comprising multi-attribute method and ligand binding assay [0.03%]
一种针对单克隆抗体早期阶段配方开发的简化工作流程，包括多属性方法和配体结合测定
Rachel Smith,Colin Guy,Rosie Upton et al.
Rachel Smith et al.
A streamlined early phase formulation development workflow has been developed for monoclonal antibodies (mAbs) to provide a more efficient process, driving down costs and reducing timelines, without compromising the quality and hence patien...
Determination of antigen components in inactivated SARS-CoV-2 vaccine using ultra-high-performance liquid chromatography tandem mass spectrometry [0.03%]
使用超高效液相色谱-串联质谱法测定灭活新型冠状病毒疫苗抗原组分
Jiexia Shi,Fenfang Deng,Yongxian Li et al.
Jiexia Shi et al.
Accurate and reliable quantification of antigen components in vaccines is critical in vaccine quality control and evaluation of immunogenic consistency. However, conventional immunoassays often suffer from limited specificity, trace-level a...