Development and validation of an UHPLC-MS/MS method for simultaneous quantification of Tazobactam, Meropenem, Vancomycin, Linezolid and Piperacillin in human plasma: Application in critically ill patients [0.03%]
一种用于同时定量人血浆中他唑巴坦、美罗培南、万古霉素、利奈唑胺和哌拉西林的UHPLC-MS/MS方法的开发与验证：在重症患者中的应用
Jacopo Lucchetti,Claudia Fracasso,Davide Cesana et al.
Jacopo Lucchetti et al.
Antibiotic treatment for severe infections in critically ill patients might be challenging. The pathophysiological changes occurring in these patients can alter the pharmacokinetic profiles of antibiotics, resulting in ineffective or incorr...
Deep eutectic solvent-assisted magnetic nanoparticle extraction of curdione from Curcuma wenyujin for analytical and bioactivity evaluation [0.03%]
分析和生物活性评价中利用深吴太溶剂辅助磁纳米颗粒提取姜黄素疣柄菌中的 curdione
Hao Yuan,Jianliang Li,Shoujun Chen et al.
Hao Yuan et al.
To improve the extraction efficiency of hydrophobic bioactive compounds and reduce organic solvent consumption, a deep eutectic solvent-assisted magnetic nanoparticle (DES-MNPs) extraction method was developed for the determination of curdi...
Development and validation of a rapid UPLC-MS/MS method for quantifying bevacizumab in human plasma and application in Chinese cancer patients [0.03%]
人血浆中贝伐单抗的快速UPLC-MS/MS测定方法的建立及验证和在中国癌症患者中的应用
Hua Yang,Weiwei Song,Ming Yang et al.
Hua Yang et al.
Bevacizumab, a monoclonal antibody targeting vascular endothelial growth factor, is widely used in the treatment of various cancers. Despite its efficacy, the drug exhibits significant interindividual variability in pharmacokinetics and cli...
A sustainable optical nanosensor based on biogenic mesoporous silica and a chromophore for ultra-trace Fe³ ⁺ determination in environmental and pharmaceutical samples [0.03%]
一种基于生物介孔二氧化硅和发色的可持续性光学纳米传感器用于环境和药学样品中Fe³⁺的超痕量测定
Abdu Subaihi,Ahmed Alharbi,Wesam M Hussein et al.
Abdu Subaihi et al.
In this work, a highly responsive chemo-sensor was designed for the trace determination of Fe³ ⁺ ions in industrial wastewater. The sensing platform is constructed by anchoring the 3-allyl-5-[(4-nitrophenylazo)-2-thioxothiazolidin-4-one (...
Validation of a quantitative analysis method for tryptophan metabolites in asthmatic mice and bacteria using GC-MS/MS [0.03%]
基于GC-MS/MS技术的哮喘小鼠及细菌中色氨酸代谢物定量方法学研究
Weichen Xu,Mengqing Shang,Zichen Luo et al.
Weichen Xu et al.
This study established a gas chromatography-tandem mass spectrometry (GC-MS/MS) method for the simultaneous quantification of 25 tryptophan (TRP) metabolites encompassing the kynurenine pathway, serotonin pathway, and indole pathway. The me...
UHPLC-Orbitrap-HRMS-based metabolite identification and profiling of methylophiopogonone A, A bioactive constituent from Ophiopogon japonicus [0.03%]
基于UHPLC-Orbitrap-HRMS的甲基麦角硫明A的代谢物鉴定及代谢轮廓研究
Yujie Zhu,Peng Zhang,Mengying Cao et al.
Yujie Zhu et al.
Methylophiopogonone A (MON-A), an anti-inflammatory constituent of Ophiopogon japonicus, demonstrates therapeutic potential for liver fibrosis in patients with chronic hepatitis B and SARS-CoV-2 infection. This study aimed to investigate it...
A novel pharmacokinetics-pharmacodynamics strategy for effective components exploration combined with metabolomics and proteomics: Application to Xingbei Zhike granule [0.03%]
一种结合代谢组学和蛋白质组学的药代动力学-药效学策略的新方法用于有效成分探索及其在醒脾止渴颗粒中的应用研究
Xia Gao,MingKe Yin,Jing Liu et al.
Xia Gao et al.
Traditional Chinese medicine (TCM) is characterized by its complex and diverse components, difficult to identify the effective components. In this study, a pharmacokinetics (PK)-pharmacodynamics (PD) strategy, integrating chemical component...
Targeted phytocannabinomics provides new insights into the biosynthetic origin of cis-Δ⁹-THCA in Cannabis sativa L [0.03%]
针对大麻植物 cannabinoid 的目标研究为 Cannabis sativa L.中cis-Δ⁹-THCA的生物合成起源提供了新的见解
Luca Buccolieri,Roberta Paris,Flavia Fulvio et al.
Luca Buccolieri et al.
Recent studies have reported the occurrence of cis-Δ⁹-tetrahydrocannabinol (cis-Δ⁹-THC) and its carboxylated precursor, cis-Δ⁹-tetrahydrocannabinolic acid (cis-Δ⁹-THCA), minor isomers of the well-known trans counterparts. However, t...
Simultaneous quantification and aerodynamic particle size distribution analysis of tiotropium bromide and olodaterol in nebulized aerosol using UHPLC-MS/MS [0.03%]
超高效液相色谱串联质谱法同时测定雾化气溶剂中噻托溴铵和奥达特罗及其粒径分布
Jing Dou,Yawen Hong,Renyun Qian et al.
Jing Dou et al.
Fixed-dose combination (FDC) inhaled aerosols require precise characterization of both active pharmaceutical ingredients (APIs) and aerodynamic properties to ensure therapeutic efficacy and safety. This study established and validated a sen...
The drug substance of traditional Japanese Kampo medicines retains exosome-like nanoparticles derived from crude drugs [0.03%]
传统日本汉方药中的活性成分中含有源自生药的外泌体样纳米颗粒
Naoko Tsuchiya,Takashi Matsumoto,Masashi Hiramoto et al.
Naoko Tsuchiya et al.
Recent studies have highlighted the diverse roles of extracellular vesicles, which have been detected in natural products such as ginger and ginseng. This study examined whether traditional Japanese Kampo medicines also contain extracellula...