Bridging the gap: A systematic approach to integrating serum and plasma proteomic datasets for biomarker studies [0.03%]
搭建桥梁：整合血清和血浆蛋白组数据集用于生物标志物研究的系统方法学 접근策略
Coren Lahav,Nili Dahan,Michal Harel et al.
Coren Lahav et al.
Serum and plasma are widely used in proteomic biomarker discovery, but differences between their proteomes have hindered the integration of data from the two specimen types. Here, we describe a computational approach for bridging between se...
Physicochemical and biological characterization of GNR-087, a Tocilizumab biosimilar [0.03%]
GNR-087的理化和生物特性分析——托珠单抗类似药
Valentina D Gusarova,Ivan V Lyagoskin,Maksim B Degterev et al.
Valentina D Gusarova et al.
GNR-087 developed by IBC Generium, Russia is a biosimilar candidate to Tocilizumab reference product. A comprehensive analytical assessment of the structural and functional similarity of GNR-087 and Tocilizumab reference product is one of t...
In vitro metabolic profiling of weight-loss-inducing amylin receptor agonists in the context of preventive doping research [0.03%]
预防性反兴奋剂研究中的减肥诱导胰岛素生长抑素受体激动剂的体外代谢谱分析
Hana Alhalabi,Lisa Borschel,Christelle Le Foll et al.
Hana Alhalabi et al.
Peptide hormone-based weight-loss therapeutics have gained increasing attention, driven amongst other reasons, by the clinical and commercial success of semaglutide. Their increasing accessibility raises concerns about their potential misus...
Integrating plasma metabolomics using UPLC-Q Exactive Orbitrap HRMS and targeted amino acid and neurotransmitter analysis in plasma and cerebrospinal fluid by LC-MS/MS to explore biomarkers in pregnancy women with insomnia [0.03%]
采用UPLC-Q Exactive Orbitrap高分辨质谱非靶向血浆代谢组学整合及LC-MS/MS技术血浆与脑脊液中氨基酸和神经递质靶向分析探索失眠孕妇的生物标志物
Yang Han,Jindong Chen,Guangxue Chen et al.
Yang Han et al.
Insomnia is a common sleep issue among pregnant women. This study aimed to explore the metabolic characteristics of pregnant women with insomnia and identify potential biomarkers through plasma and cerebrospinal fluid (CSF) metabolomics ana...
3-mercaptopropionic acid agent-based biosensor system using gold-screen printed electrode for aflatoxin B1 detection [0.03%]
一种使用金-丝网印刷电极的基于3-巯基丙酸药物的生物传感器系统用于黄曲霉毒素B1检测
Burçak Demi̇rbakan,Ahmet Çeti̇nkaya,Evrim Güneş Altuntaş et al.
Burçak Demi̇rbakan et al.
A novel electrochemical biosensor was constructed for the ultrasensitive detection of aflatoxin B1 (AFB1) in food samples. The biosensor design was based on a 3-mercaptopropionic acid (3-MPA)-modified self-assembled monolayer (SAM) construc...
Corrigendum to "Integrative analysis of transcriptome and metabolome provide new insights into mechanisms of capilliposide A against cisplatin-induced nephrotoxicity" [J. Pharm. Biomed. Anal. 238 (2024), 115814] [0.03%]
“转录组和代谢组整合分析为帽利波苷A对抗顺铂所致肾毒性的机制提供新见解”一文的勘误[Journal of Pharmaceutical and Biomedical Analysis, Volume 238, January 2024, 115814]
Jiaxi Fang,Luping Wang,Di Zhang et al.
Jiaxi Fang et al.
Metabolomics technology combined with O2PLS analysis reveals the active components of Paeoniae Radix Alba in preventing renal damage in rheumatoid arthritis [0.03%]
结合代谢组学及O2PLS分析技术揭示白芍预防类风湿性关节炎肾损伤的活性成分
Shuyi Lv,Jiayi Lin,Yu Sun et al.
Shuyi Lv et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by symmetrical, erosive polyarthritis and multi-organ involvement, with renal complications posing a life-threatening risk. Paeoniae Radix Alba, known as BaiShao (BS) ...
A novel thin layer chromatography based method for the quantification of quillaic acid saponins [0.03%]
一种用于定量拟南芥皂苷的新型薄层色谱法
Fabian E Bülow,Adam Matkowski,Alexander Weng
Fabian E Bülow
Saponins display medicinal properties such as enhancing the drug delivery of biologicals, and boosting immune responses within vaccinations. As plant derived molecules, their phytochemical analysis is key to ensure pharmaceutical quality. T...
Serum metabolomics reveal metabolic changes in coal workers' pneumoconiosis progression [0.03%]
血清代谢组学揭示煤工尘肺病进展中的代谢变化
Jiyu Xu,Mingyao Wang,Zhifei Hou et al.
Jiyu Xu et al.
Chronic inhalation of coal dust causes coal workers' pneumoconiosis (CWP), which is one of the leading occupational diseases. Coal workers' pneumoconiosis is currently incurable, posing a serious public health threat. Identifying the underl...
Construction of bio-layer interferometry biosensors via cell-free synthesized proteins for fishing bioactive compounds from Chinese herbs [0.03%]
通过无细胞合成蛋白质构建生物干涉测量法生物传感器从中药中筛选生物活性化合物
Yanting Wang,Xiaofei Wang,Ningqi Xia et al.
Yanting Wang et al.
The application of Bio-Layer Interferometry (BLI) is contingent upon the immobilization of highly purified target proteins onto the sensor. The cumbersome and time-consuming nature of traditional protein expression and purification processe...