Simultaneous quantification of fat- and water-soluble vitamins in serum by valve-mediated dual LC-MS/MS [0.03%]
基于阀切换的双UPLC-MS/MS测定血清中脂溶性和水溶性维生素的方法
Weifeng Li,Ka Luo,Hou Qian et al.
Weifeng Li et al.
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the benchmark platform for multiplex vitamin quantification, yet simultaneous determination of chemically disparate fat-soluble (FSVs) and water-soluble vitamins (WSVs) remains an...
Counterfeit thyroid medications: A comprehensive analysis of the composition of products seized by law enforcement using liquid chromatography coupled with mass spectrometry [0.03%]
假冒甲状腺药物的全面分析：法律执行机关扣押的产品中使用液相色谱-串联质谱法研究其组成成分
Agnieszka Kalicka,Anna Kierasińska,Piotr Woźniak et al.
Agnieszka Kalicka et al.
Drug counterfeiting is a global public health challenge affecting both developed and developing countries. This study reports the first comprehensive quality assessment of falsified medicinal products containing thyroid hormones (liothyroni...
Digital multidimensional fingerprinting and monolinear method quantitation for quality consistency of traditional chinese medicine injection [0.03%]
数字化多维度指纹图谱及单线性方法一致性评价用于中药注射剂质量控制
Kaining Zhou,Yu Ren,Jianglei Zhang et al.
Kaining Zhou et al.
Traditional Chinese medicine (TCM) injections require stringent batch-to-batch quality control. This study established a digital, multidimensional fingerprinting workflow for Ixeris sonchifolia (Bunge) Hance injection (ISHI), integrating: (...
Exploring potential mechanism of Chuanzhi Qingyu recipe for vulnerable atherosclerosis plaques based on UPLC-Q-TOF-MSE, systems biology strategy, and experimental validation [0.03%]
基于UPLC-Q-TOF-MSE、系统生物学策略及实验验证的穿心清淤方防治易损斑块潜在机制探讨研究
Jiajun Weng,Luyao Huan,Shiyu Zhang et al.
Jiajun Weng et al.
Chuanzhi Qingyu (CZQY) recipe is clinically used for the secondary prevention and treatment of cardiovascular diseases associated with atherosclerosis (AS) However, the potential active components and underlying molecular mechanisms require...
Analytical approaches for the determination of nitrate and nitrite in infant and baby foods: Advances and occurrence [0.03%]
婴幼儿食品中硝酸盐和亚硝酸盐测定的分析方法：进展及发生情况
Zeynep Kalaycıoğlu,Ayşegül Gölcü
Zeynep Kalaycıoğlu
Infant and baby foods may contain nitrate and nitrite due to the accumulation of these ions in plant-based ingredients, and although nitrate itself is not acutely toxic, its potential conversion to nitrite and subsequent health risks necess...
Integrating non-targeted metabolomics and machine learning for comprehensive phytochemical profiling and intelligent discrimination of Acorus tatarinowii and its adulterants [0.03%]
基于非目标代谢组学和机器学习的石菖蒲属植物化学全面特征及智能判别体系建立
Jia-Wei Wang,Xiao-Kang Liu,Fei Huang et al.
Jia-Wei Wang et al.
The dried rhizome of Acorus tatarinowii Schott (SCP) is a valued medicinal material in traditional Chinese medicine (TCM). However, its quality and efficacy are often compromised by adulteration with morphologically and chemically similar s...
Insights into the mechanism of treatment of ulcerative colitis with pre- and post-processed dried ginger through perspective of metabolomics and intestinal microbiomics research [0.03%]
基于代谢组学和肠道微生物组学研究透解炮制姜对溃疡性结肠炎治疗作用机制的初步洞察
Siming Han,Xiaotong Yang,Jie Du et al.
Siming Han et al.
Numerous experiments and clinical practices have demonstrated the distinct therapeutic effect of dried ginger (DG) and processed ginger (PG) in the treatment of ulcerative colitis (UC), while, the differences in efficacy and mechanisms are ...
Simultaneous quantification of chondroitin sulfate and dermatan sulfate in crude heparins using 1H NMR and independent component analysis [0.03%]
利用核磁共振和独立成分分析同时量化粗肝素中的硫酸软骨素和 dermatan 硫酸素
René Burger,Xuan Tung Do,Bernd W K Diehl et al.
René Burger et al.
Heparin, an essential anticoagulant in clinical practice, is susceptible to contamination with chondroitin sulfate (CS) and dermatan sulfate (DS). Ensuring the reliable quantification of these polysaccharides in crude heparins is critical f...
Development and validation of a robust UPLC-MS/MS method for the analysis of polyamines in cells, biofluids and tissues [0.03%]
一种用于分析细胞、生物体液和组织中聚胺的稳健型UPLC-MS/MS方法的研发与验证
Michele Iannone,Liesbeth Vereyken,Elien Grajchen et al.
Michele Iannone et al.
Loss of function (LoF) of the ATP13A2 protein, a polyamines transporter, has been linked to lysosomal and mitochondrial dysfunctions that play an important role in the early onset of Parkinson's disease (PD) and related neurodegenerative di...
An integrative strategy combining network pharmacology, metabolomics, and gut microbiota analyses to elucidate the bioactive ingredients and underlying mechanisms of Xin-Shu-Ning tablets against myocardial ischemia [0.03%]
整合网络药理学、代谢组学和肠道微生物组分析的策略，阐明新舒宁片抗心肌缺血活性成分及机制
Yipeng Gu,Haixia Huang,Yanrong Liu et al.
Yipeng Gu et al.
Xin-Shu-Ning tablets (XSNT) are clinically used for the treatment of angina pectoris and coronary insufficiency; however, their bioactive constituents and cardioprotective mechanisms remain insufficiently clarified. In this study, an integr...