Pharmaceutical insights into nanoscale drug delivery systems and chromatographic approaches for melanoma treatment [0.03%]
纳米药物输送系统及用于治疗黑色素瘤的色谱方法的药学见解
Armineh Deljavan Ghodrati,Weldejeworgis Gebrehiwot,Gulin Amasya et al.
Armineh Deljavan Ghodrati et al.
Due to its potential for metastasis and resistance to standard treatments, melanoma, a very aggressive type of skin cancer, presents substantial challenges in clinical care. Nanocarrier based approaches have become a viable tactic to overco...
Investigation of distinct metabolic profiles in the phloem and xylem of Rehmanniae Radix using untargeted metabolomics coupled with quantification of glycosides [0.03%]
基于非靶向代谢组学结合糖苷类化合物定量的丹参根茎输导组织差异分析研究
Ting Shang,Hanxiao Liu,Jianguang Zhu et al.
Ting Shang et al.
This study aimed to investigate the composition and differences in phytochemicals between the phloem and xylem of Rehmanniae Radix (RR). The metabolic profiles of two tissues were comprehensively characterized using untargeted metabolomics,...
Ultra-sensitive HPLC-ESI-MS/MS quantitation of N-nitroso-phenylephrine in phenylephrine-containing anticold products [0.03%]
含伪麻黄碱抗感冒制剂中N-亚硝基伪麻黄碱的超痕量测定(HPLC-ESI-MS/MS)
Pál T Szabó,András Darcsi,Gábor Turczel et al.
Pál T Szabó et al.
Phenylephrine is widely used in anticold medications and contains a secondary amine moiety capable of forming N-nitroso-phenylephrine (NNPE), a potentially carcinogenic nitrosamine impurity. Despite increasing attention to nitrosamine conta...
Pharmacokinetic profiling of the bioactive components of Sijunzi Decoction in a rat model of breast cancer: Insights into herb-drug interactions with cyclophosphamide [0.03%]
四君子汤活性成分在乳腺癌大鼠模型中的药代动力学特征研究：与环磷酰胺药物-药物相互作用的启示
Zaimei Zhang,Yumeng Zhang,Rongrong Gao et al.
Zaimei Zhang et al.
This study investigated the pharmacokinetics of Sijunzi Decoction (SJZD) components and their interactions with cyclophosphamide (CTX) in breast cancer (BC) rats. The BC model was induced using 7,12-dimethylbenz[a]anthracene (DMBA). Using U...
Identification of characteristic volatile compounds in Artemisiae argyi Levl. et Vant. from diverse origins using E-nose and HS-GC-IMS [0.03%]
基于电子鼻和HS-GC-IMS技术的艾叶特征挥发性成分识别
Rui Ma,Ruiying Zhang,Weimeng Feng et al.
Rui Ma et al.
Artemisia argyi Levl. et Vant., a traditional Chinese medicinal herb, is highly regarded for its therapeutic properties, including antimicrobial, anti-inflammatory, analgesic, and anticancer effects. However, the quality of A. argyi varies ...
Corrigendum to "High-throughput quantitation of serological dimethylarginines by LC/MS/MS: Potential cardiovascular biomarkers for rheumatoid arthritis", [J. Pharm. Biomed. Anal., vol. 232, Article Number 115336] [0.03%]
“高通量定量测定自身免疫疾病患者血清中不对称二甲基精氨酸的含量：潜在的心血管生物标志物”文章的勘误(卷232，115336)
Qianyang Huang,Ying Liu,Yuna Cheng et al.
Qianyang Huang et al.
Systematic characterization of chemical constituents and in vivo metabolites of Jiuwei Qianghuo Granules by UPLC-Q-TOF-MS/MS [0.03%]
基于UPLC-Q-TOF-MS/MS技术的九味羌活颗粒体内化学成分及代谢产物系统分析方法学研究
Zihang Xu,Chen Zhou,Mengru Wu et al.
Zihang Xu et al.
Jiuwei Qianghuo Granules (JWQHG), a classical traditional Chinese medicinal preparation composed of nine herbs, has been widely used in clinical practice for centuries. However, its chemical composition and metabolic fate in vivo remain ins...
Plasma-based near-infrared spectroscopy combined with aquaphotomics for colorectal cancer screening [0.03%]
结合Aquaphotomics的近红外光谱法在结直肠癌筛查中的应用研究
Zhongjian Chen,Wenya Zhang,Juan Ni et al.
Zhongjian Chen et al.
Fast, noninvasive and cost-effective methods for screening colorectal cancer (CRC) before uncomfortable colonoscopy are highly desirable. This study aimed to explore the feasibility of using near-infrared spectroscopy (NIRS) combined with a...
In-depth source characterization and analytical control strategy for the charge variants of antibody drug conjugates: Case study and discussion [0.03%]
抗体偶联药物的电荷异构体的深入来源表征及分析控制策略：案例研究与讨论
Gangling Xu,Sihan Wei,Gang Wu et al.
Gangling Xu et al.
Antibody-drug conjugates (ADCs) combine the dual characteristics of antibody targeting and high payload potency. ADCs represent a key technology in targeted therapy and have become a major direction in "precision" medicine. Charge variants ...
Spatio-temporal analysis deciphers the energy metabolism disorders in depression based on stable isotope-resolved metabolomics [0.03%]
基于稳定同位素解析代谢组学的抑郁症时空分析揭示能量代谢障碍
Ting Linghu,Xubin Gu,Yunhao Zhao et al.
Ting Linghu et al.
The significant impact of depression on human life has attracted great attention. However, the unclear and highly complex pathogenesis of depression has resulted in the limited efficacy of currently available antidepressants. Therefore, it ...