Isolation and identification of the designer benzodiazepine cyclopropylflualprazolam in pressed candies marketed for sleep improvement [0.03%]
从宣称为改善睡眠而销售的压片糖果中分离和鉴定新型合成大麻素HHC-β-CYCLE及精神药物环丙利福拉唑氨酚
Xiaopu Liu,Lihong Zhao,Peizhi Dong et al.
Xiaopu Liu et al.
A novel alprazolam analog was detected as an illegal additive in pressed candies marketed for sleep improvement using high-performance liquid chromatography (HPLC)-diode array detection (DAD). The compound was further isolated and purified ...
E-nose, HS-SPME-GC-MS and untargeted metabolomics reveal effects on 60Co gamma irradiation of Neng-An-Jun-Ning Pills: Changes in odor and chemical compositions [0.03%]
电子鼻、HS-SPME-GC-MS和非靶标代谢组学揭示了~(60)Coγ射线辐照对宁安君宁片的影响：气味及化学成分的变化
Zihong Wang,Juhong An,Renqing Daji et al.
Zihong Wang et al.
Tibetan medicinal preparations are mainly composed of crude medicinal powder, which are susceptible to microbial contamination. Due to its high efficiency and low-treatment characteristics, ⁶⁰Co gamma irradiation is currently the most com...
Polysaccharide-driven quality control of Gastrodia elata Blume: A multidimensional strategy integrating LC-MS/MS-based quantitative analysis, machine learning, and anti-neuroinflammatory bioactivity [0.03%]
基于LC-MS/MS定量分析、机器学习和抗神经炎症生物活性的天麻多糖质量控制：一种多维策略
Xinqin Kong,Sihan Chen,Liling Shen et al.
Xinqin Kong et al.
Gastrodia elata Blume (GE), a highly regarded traditional Chinese medicinal herb, is widely recognized for its diverse pharmacological activities. Current quality control primarily relies on small molecule biomarkers, yet critical research ...
Detection and quantification of ezetimibe and its major glucuronide in patients with hepatic impairment via liquid chromatography-tandem mass spectrometry [0.03%]
LC-MS/MS测定肝功能不全患者血浆中依折麦布及其主要葡萄糖醛酸结合物的方法及应用
Dominique O Farrera,Max M Maloney,Christopher S LaMadrid et al.
Dominique O Farrera et al.
Following administration of ezetimibe (EZE), levels of the glucuronidated metabolite ezetimibe-glucuronide (EZEG) are altered in patients with hepatic impairment. A rapid and sensitive liquid chromatography-tandem mass spectrometry method (...
Metabolic profile of 25E-NBOH in human liver microsomes, rat urine, and fungus Cunninghamella elegans [0.03%]
一种新型致幻剂25E-NBOMe的人肝微粒体代谢、大鼠尿液和真菌 Cunninghamella elegans代谢轮廓研究
Magdaléna Vágnerová,Petr Palivec,Monika Mrňavá et al.
Magdaléna Vágnerová et al.
N-benzylphenethylamines are a class of new psychoactive substances (NPS) that are increasingly being used as recreational drugs with a wide range of adverse effects, possibly even death. Currently, the appearance of new N-benzylphenethylami...
Corrigendum to "Systematic characterization of chemical constituents and in vivo metabolites of Jiuwei Qianghuo Granules by UPLC-Q-TOF-MS/MS" [J. Pharm. Biomed. Anal. 274 (2026) 117443] [0.03%]
“九味羌活颗粒化学成分及体内代谢产物的系统表征”（Journal of Pharmaceutical and Biomedical Analysis，2021年第274卷117443号）的勘误表
Zihang Xu,Chen Zhou,Mengru Wu et al.
Zihang Xu et al.
Untargeted LC-MS-based metabolic fingerprinting of Escherichia coli-associated urinary tract infections and urosepsis: Insights into the urine, serum, and bacterial interactomes [0.03%]
基于LC-MS的未靶标代谢指纹分析：尿液，血清和细菌互作组在大肠杆菌相关性尿路感染及败血症中的作用
Paweł Wityk,Joanna Raczak-Gutknecht,Margot Biesemans et al.
Paweł Wityk et al.
Urinary tract infections (UTIs) and urosepsis necessitate a deeper understanding of host-pathogen interactions at the metabolic level. We use LC-MS and GC-MS techniques to characterize metabolic pathway alterations in patients and Escherich...
Unraveling the heterogeneity of hyperuricemia using untargeted metabolomics and statistical modeling [0.03%]
基于非靶向代谢组学和统计模型解析高尿酸血症的异质性
Juan Wang,Zhongda Zeng,Wei Duan et al.
Juan Wang et al.
Hyperuricemia is the second most prevalent metabolic disorder globally and exhibits pronounced heterogeneity in clinical practice. Only about 10% of individuals with asymptomatic hyperuricemia (HUA) progress to gout, yet the lack of specifi...
Development of a MS binding assay to analyze the interactions of drugs with the ifenprodil binding site of NMDA receptors with GluN2B subunit [0.03%]
一种分析药物与含GluN2B亚单位的N-甲基-D天冬氨酸受体ifenprodil结合位点相互作用的MS结合测定法的研究开发
Lucie Grey,Jörg Fabian,Dirk Schepmann et al.
Lucie Grey et al.
Negative allosteric modulators interacting with the ifenprodil binding site of NMDA receptors with GluN2B subunit are of particular interest for the treatment of psychiatric and neurodegenerative disorders. In order to eliminate the radioli...
Development and validation of an efficient and sensitive LC-MS/MS assay for simultaneous determination of the high frequency used antibody drug conjugate payload MMAE and anti-vascular tyrosine kinase inhibitor lenvatinib in human plasma [0.03%]
一种高效、灵敏的液相色谱串联质谱检测法的同时测定人血浆中抗体药物偶联物高频率使用有效载荷MMAE和抗血管酪氨酸激酶抑制剂乐伐替尼的方法学建立与验证
Yongqing Wen,Wenjuan Wang,Xu Ma et al.
Yongqing Wen et al.
Antibody drug conjugates (ADCs)-based combination therapies are increasingly studied in clinics. Monomethyl auristatin E (MMAE) is the most frequently used payload in approved ADCs and lenvatinib is a classic anti-vascular tyrosine kinase i...