Development and validation of a GC-MS method for the simultaneous determination of bisphenols, phthalate monoesters, and triclosan in human meconium for comprehensive prenatal exposure assessment [0.03%]
人胎粪中双酚类、邻苯二甲酸单酯和三氯叔丁醇的同时测定法的发展与验证，以全面评估宫内接触情况
Kenan Can Tok,Mehmet Gumustas,Khaled Mohamed Masoud et al.
Kenan Can Tok et al.
Determining in utero exposure to endocrine-disrupting chemicals (EDCs) is crucial for public health, given their widespread presence and high production volumes. Analyzing EDCs, such as bisphenols, phthalate monoesters, and triclosan in mec...
Monitoring disulfide scrambling of monoclonal antibody biologics using liquid chromatography-mass spectrometry coupled to online electrochemical reduction [0.03%]
基于电化学还原的液相色谱-质谱抗体二硫键异构化检测方法研究
Lushuang Huang,Yunlong Zhao,Yuan Mao et al.
Lushuang Huang et al.
Electrochemical flow-cell (EC) devices have been used to perform online reduction of disulfide bonds found in both peptides and full-length proteins. This study demonstrates the use of a liquid chromatography-EC-mass spectrometry (LC-EC-MS)...
Illuminating biomarkers: Metal-based strategies and fluorescence nanosensors for clinical monitoring [0.03%]
基于金属的策略和荧光纳米传感器在临床监测中的应用及生物标志物的研究
Galal Magdy,Mohamed A M Ali,Rehab H Elattar et al.
Galal Magdy et al.
Plasmonic and fluorescence nanosensors have become vital tools for recent diagnostic applications due to their great sensitivity, rapid response, and capacity to determine very small amounts of biological targets. Plasmonic sensors rely on ...
Corrigendum to "Characterizing the metabolites of the tyrosine-kinase inhibitor pexidartinib in mouse feces, urine, plasma, and liver" [J. Pharm. Biomed. Anal. 265 (2025) 117034] [0.03%]
“表征酪氨酸激酶抑制剂pexidartinib在小鼠粪便、尿液、血浆和肝脏中的代谢产物”一文的勘误注释[J. Pharm. Biomed. Anal. 265 (2021) 117034]
Xuan Qin,Si Chen,John M Hakenjos et al.
Xuan Qin et al.
Illuminating the Dark Host Cell Proteome: A host cell protein coverage method for LC-MS impurity assays [0.03%]
点亮“暗宿主蛋白组”——一种适用于LC-MS杂质测定的宿主细胞蛋白覆盖度方法
Victor G Chrone,Mads Kofoed,Anette H Draborg et al.
Victor G Chrone et al.
Host cell protein (HCP) analysis by liquid chromatography-mass spectrometry (LC-MS) enables identification and quantification of individual impurities in biopharmaceutical products, supporting risk-based impurity assessment. However, unlike...
Identification, toxicity evaluation, and HPLC-based quality control method development of process-related impurities and degradation products of belumosudil mesylate [0.03%]
贝勒莫舒第硫酸盐工艺相关杂质和降解产物的识别、毒性评价及HPLC质量控制方法研究
Yabo Wang,Zhengwei Wu,Zhangjian Han et al.
Yabo Wang et al.
As an oral small-molecule drug that selectively inhibits ROCK2, Belm exhibits unique advantages in the treatment of hormone-dependent/refractory cGVHD. However, impurity control and stability during the production of its API remain key chal...
Sensitive and selective quantification of elcatonin in equine plasma and urine using LC-FAIMS-MS/MS [0.03%]
基于LC-FAIMS-MS/MS的马血浆和尿液中尔康肽的灵敏度及选择性测定法
Kohei Ohnuma,Minori Fukazawa,Taiga Uchida et al.
Kohei Ohnuma et al.
The use of drugs for enhancing bone strength is prohibited under international regulations governing horse racing and equestrian sports. Elcatonin, a synthetic peptide with analgesic and bone-strengthening properties, is routinely monitored...
A validated ligand binding assay for the determination of etalanetug, a novel anti-tau therapeutic antibody, in rats and monkeys for nonclinical pharmacokinetic studies [0.03%]
一种用于大鼠和猴体内eticsatug（抗tau蛋白治疗性抗体）药代动力学研究的生物分析方法的验证
Muneo Aoyama,Yumiko Noritake,Kenji Kita et al.
Muneo Aoyama et al.
Etalanetug (E2814) is a novel human monoclonal antibody targeting tau that is currently being developed as a biotherapeutic for Alzheimer's disease. To inform pharmacological and toxicological evaluations in nonclinical settings and to guid...
Investigation of excipient-related artifacts observed in the leachables study of tiragolumab by LC-HRMS and GC-MS [0.03%]
液相色谱高分辨率质谱和气相色谱质谱在替拉珠单抗浸出物研究中观察到的辅料相关衍生杂质研究调查
Jie Du,Richard Pearson,Yuyin Zhou et al.
Jie Du et al.
Leachables studies of protein formulations are faced with many analytical challenges arising from relatively high levels of complex formulation components. In the stressed sample of the monoclonal antibody drug tiragolumab with the main exc...
Comprehensive impurity profiling and stability assessment of indacaterol maleate integrating LC-MS and in silico genotoxicity [0.03%]
马来酸茚地特罗的综合杂质谱分析及稳定性研究结合LC-MS和计算致突变性评估
Çağla Aydın,Yücel Yazar,Halil Yılmaz et al.
Çağla Aydın et al.
This study describes the development and validation of stability-indicating analytical methods for indacaterol maleate, an ultra-long-acting β2-adrenoceptor agonist used in asthma and chronic obstructive pulmonary disease (COPD). RP-HPLC-U...