LC-MS/MS metabolite profiling, molecular networking and cyclooxygenase inhibition activity of Hornstedtia conoidea and Etlingera elatior extracts: In vitro and in silico insights [0.03%]
Jason C Alcano,Anna Karen C Laserna,Mark Tristan J Quimque et al.
Jason C Alcano et al.
Inflammation is a complex physiological response implicated in infectious and metabolic diseases. Although nonsteroidal anti-inflammatory drugs (NSAIDs) effectively reduce inflammation through cyclooxygenase (COX) inhibition, their poor iso...
Unraveling the phenolic profiles of Clinopodium bolivianum (Benth.) Kuntze and Minthostachys mollis (Benth.) Griseb.: A comprehensive LC-QtoF metabolomic study of underexplored Peruvian medicinal plants [0.03%]
Natalia García-Acosta,Ignacio Moratilla-Rivera,Marta Jordán et al.
Natalia García-Acosta et al.
Medicinal plants remain a primary healthcare resource worldwide, particularly in regions with strong cultural traditions and limited economic development. In Peru, muña [Minthostachys mollis (Benth.) Griseb.] and inca muña [Clinopodium bo...
Study of GJKBW against RA based on the Chinmedomics combined LIP-MS molecular fishing technology: A new strategy for discovering the therapeutic material basis [0.03%]
Xin Zha,Long-Yu Yao,Wen-Wei Gong et al.
Xin Zha et al.
Rheumatoid arthritis (RA) is a major chronic autoimmune disease. Current conventional drugs face significant challenges, including severe side effects, high recurrence rates, and unsuitability for long-term use. In contrast, traditional Chi...
A progressive screening strategy by combining UHPLCQTOF-MS and machine learning for distinguishing different varieties of Citri Reticulatae Pericarpium [0.03%]
Defang Hu,Minyong Zhong,Zerong Pei et al.
Defang Hu et al.
This study employed UHPLC-QTOF-MS-based untargeted metabolomics, integrated with chemometrics and machine learning, to discriminate between varieties of Citri Reticulatae Pericarpium (CRP). To identify specific markers between each pair of ...
Identification of ursolic acid from Wumei as a syk-targeting anti-allergic agent using a piezoresistive cantilever biosensor [0.03%]
Zhan Xu,Bin Miao,Zhiqi Gu et al.
Zhan Xu et al.
Wumei (WM), a historical food and medicine homology fruit in China, is reported to have anti-allergic effect, yet its active components and mechanisms remain unclear. Here, a novel spleen tyrosine kinase-based piezoresistive cantilever arra...
Matrix-dependent degradation kinetics and impurity fingerprinting of cannabidiol (CBD) in polymeric and lipid preservation systems [0.03%]
基于矩阵的降解动力学和杂质指纹鉴定聚集体和脂质保鲜系统中的大麻二酚(CBD)
Qurat Ul Ain Haidery,Bo Han,Rashid Saeed et al.
Qurat Ul Ain Haidery et al.
Cannabidiol (CBD), a non-psychoactive terpenophenolic compound derived from Cannabis sativa, exhibits broad-spectrum pharmacological activities but is highly susceptible to oxidative, photolytic, and thermal degradation, making it challengi...
Simultaneous quantification of active ingredients after the combination of Shenqi Fuzheng injection and docetaxel in vitro and in rabbits [0.03%]
参附注射液与多西他赛体外以及在兔体内的复方配伍定量分析研究
Yanqiong Luo,Dan Zeng,Jiawen Liu et al.
Yanqiong Luo et al.
Shenqi Fuzheng injection (SFI), known for its ability to replenish Qi and strengthen vital energy, is frequently combined with docetaxel, a first-line chemotherapeutic agent, for the treatment of breast cancer in clinical practice. Although...
Self-assembled precipitates from Gegen Qinlian decoction: Physicochemical characterization, in vivo and in vitro behaviors [0.03%]
基于葛芩连汤的自组装沉淀物：物理化学性质、体内外行为研究
Zhe Chen,Zhenye Luo,Ting Xia et al.
Zhe Chen et al.
Gegen Qinlian decoction (GQD), a traditional Chinese medicine used to treat infectious diarrhea, forms self-precipitates (GQD-P) during decoction. Although GQD-P and the supernatant (GQD-S) share an identical chemical composition, their phy...
Identification of Novel Anti- non-small cell lung cancer (NSCLC) Peptide in toad Skin（Chan Pi） Extract through Integrated Peptidomics and in silico Screening [0.03%]
基于整合肽组学和计算机辅助筛选蟾皮中抗非小细胞肺癌(NSCLC)多肽的研究
Xiaoxin Tu,Jia Wu,Ying Dong et al.
Xiaoxin Tu et al.
Toad skin (Bufo bufo gargarizans Cantor), known as Chan Pi in traditional Chinese medicine, has long been recognized for its therapeutic potential, particularly in cancer treatment. While the pharmacological activities of small molecules in...
Metabolic disparities of potentially toxic components derived from Psoraleae Fructus and Euodiae Fructus within the Sishen wan influenced by varying compatibilities and physiological conditions in an in vitro gut microbiota model [0.03%]
基于体外肠道菌群模型的补骨脂果实和吴茱萸果实四神丸不同配伍及生理条件下潜在毒性成分的代谢差异性研究
Lili Hong,Lingli Ma,Jiamiao Dong et al.
Lili Hong et al.
Sishen wan (SSW) is utilized in the treatment of irritable bowel syndrome (IBS). This study aimed to compare gut microbiota-mediated metabolic profiles of potential toxicants derived from Psoraleae Fructus (PF) and Euodiae Fructus (EF) in m...