Serum untargeted metabolomics analysis of the preventive mechanism of TAETEA Prebiotea on non-alcoholic fatty liver in rats [0.03%]
TAETEA益生元对预防大鼠非酒精性脂肪肝作用机制的无靶代谢组学研究
Shijiao Zhang,Jiahang Li,Yingfan Zhai et al.
Shijiao Zhang et al.
Pu-erh tea belongs to the six tea categories of black tea, according to the processing technology and quality characteristics, is divided into two types of raw tea and ripe tea. Raw tea is made from fresh leaves of tea as raw materials, thr...
In vitro identification of single-stranded DNA aptamers targeting human IL-23 using the protein-SELEX strategy [0.03%]
利用蛋白-SELEX技术体外筛选人IL-23单链DNA适配体分子
Mohammad Ali Rezaee,Saeideh Sadat Shobeiri,Malihe Moghadam et al.
Mohammad Ali Rezaee et al.
Interleukin (IL)-23 inhibitor monoclonal antibodies shown significant efficacy in treating autoimmune diseases. DNA or RNA aptamers exhibit comparable specificity to antibodies, are cost-effective, non-immunogenic, and do not have batch to ...
NMR-based metabolomics approach to study the effect and related molecular mechanisms of Saffron essential oil against depression [0.03%]
基于核磁共振代谢组学的郁金精油抗抑郁作用及机制研究
Ying Zhou,Ziwei Chen,Feng Su et al.
Ying Zhou et al.
Depression currently ranks as the fourth leading cause of disability globally, affecting approximately 20% of the world's population. we established a chronic restraint stress (CRS) induced depression model in mice and employed fluoxetine a...
Comments Regarding "Solubility determination and thermodynamic model analysis of L-α-glyceryl phosphorylcholine in different organic solvents of 278.15-323.15 K" [0.03%]
关于“L-α-甘油磷胆碱在不同有机溶剂中的溶解度测定及热力学模型分析（278.15-323.15K）”一文的讨论
Audrey Chen,Jocelyn Chen,William E Acree Jr
Audrey Chen
A polemic is given regarding several of the calculated curve-fit parameters that Zhou and coworkers reported in their published paper. The calculated curve-fit parameters for the Combined Nearly Ideal Binary Solvent/Redlich-Kister, Jouyban-...
Comprehensive evaluation of the mechanism of Banxia Baizhu Tianma Decoction in ameliorating posterior circulation ischemia vertigo based on integrating fecal short-chain fatty acids and 16S rRNA sequencing [0.03%]
基于粪便短链脂肪酸和16S rRNA测序整合的半夏白术天麻汤改善后循环缺血性眩晕机制综合评价研究
Fangfang Huang,Zilin Wang,Zilong Zhang et al.
Fangfang Huang et al.
Posterior circulation ischemia vertigo (PCIV) is vertebrobasilar insufficiency resulting in vertigo. Banxia Baizhu Tianma Decoction (BBTD) is broadly applied to treat PCIV in China, but its efficacy and detailed mechanism remains unclear. T...
Transacylation and hydrolysis of the acyl glucuronides of ibuprofen and its α-methyl-substituted analogues investigated by 1H NMR spectroscopy and computational chemistry: Implications for drug design [0.03%]
乙基酯和甲基类似物的酰基葡萄糖苷的转乙酰化和水解作用：通过¹H核磁共振光谱学和计算化学进行研究并对其在药物设计中的影响加以说明
Selena E Richards,Peter R Bradshaw,Caroline H Johnson et al.
Selena E Richards et al.
Drugs and drug metabolites containing a carboxylic-acid moiety can undergo in vivo conjugation to form 1-β-O-acyl-glucuronides (1-β-O-AGs). In addition to hydrolysis, these conjugates can undergo spontaneous acyl migration, and anomerisat...
Bezhan Chankvetadze,Lukasz Ciesla,Sandra Furlanetto et al.
Bezhan Chankvetadze et al.
Metabolomic and biochemical changes in the plasma and liver of toxic milk mice model of Wilson disease [0.03%]
毒奶小鼠Wilson病模型血浆和肝脏代谢组及生化改变研究
Qiao Liu,Xiaoyuan Wu,Cuicui Liu et al.
Qiao Liu et al.
Wilson disease (WD) is an inherited disorder characterized by abnormal copper metabolism with complex pathological features. Currently, this mechanism of copper overload-induced hepatic injury remains unclear. In this study, male toxic milk...
Analytical Quality by Design as applied to the development of a SEC-HPLC platform procedure for the determination of monoclonal antibody purity without mobile phase additives [0.03%]
作为设计应用于开发无流动相添加剂的单克隆抗体SEC-HPLC平台测定纯度的分析质量_by_设计
Terezie Cernosek,Matthew Dalphin,Nitin Jain et al.
Terezie Cernosek et al.
This work presents the application of AQbD principles to the development of a size exclusion chromatography (SEC) HPLC procedure for the determination of monoclonal antibody (mAb) product purity using state-of-the-art column technology avai...
Development of a quantification method for arginase inhibitors by LC-MS/MS with benzoyl chloride derivatization [0.03%]
苯甲酰氯衍生化结合LC-MS/MS测定瓜氨酸和精氨代琥珀酸及其作为一氧化氮合酶底物活性的方法学研究
Eric Gosselin,Petar Pop-Damkov,Aixiang Xue et al.
Eric Gosselin et al.
Arginase is an enzyme responsible for converting arginine, a semi-essential amino acid, to ornithine and urea. Arginine depletion suppresses immunity via multiple mechanisms including inhibition of T-cell and NK cell proliferation and activ...