Development of an electrochemical sensor for the quantification of ascorbic acid and acetaminophen in pharmaceutical samples [0.03%]
一种用于测定药物样品中抗坏血酸和对乙酰氨基酚的电化传感器的开发
Alejandro Gutiérrez,María Guadalupe Ramírez-Ledesma,Gustavo A Rivas et al.
Alejandro Gutiérrez et al.
This work presents the modification of glassy carbon electrodes (GCE) by using a dispersion resulting from the non-covalent functionalization of multi-walled carbon nanotubes (MWCNT) with polyarginine (polyArg). MWCNT-polyArg is used for th...
Indicator displacement-based colorimetric assay for dibutyl phthalate in pharmaceutical products with titanium(IV)-pyridylazo resorcinol (PAR) [0.03%]
基于指示剂位移的酒石酸钛(IV)-偶氮苯酚红色反应树脂试剂测定医药产品中邻苯二甲酸二丁酯的比色法
Ülkü Nida Çolak,Elif Yılmaz,Selen Durmazel et al.
Ülkü Nida Çolak et al.
Taking advantage of the competitive binding affinity towards Ti(IV) between 4-(2-pyridylazo) resorcinol (PAR) and phthalate, a simple indicator displacement (ID)-based colorimetric assay was designed for indirect determination of a well-kno...
In vitro biotransformation of 3-methylmethcathinone (3-MMC) through incubation with human liver microsomes and cytosol and application to in vivo samples [0.03%]
人肝微粒体和细胞质孵育结合体内样品分析探讨3-甲基меthкatinоne（3-MMC）的生物转化
Natan Van Wichelen,Andrea Estévez-Danta,Lidia Belova et al.
Natan Van Wichelen et al.
Synthetic cathinones are the second largest group of new psychoactive substances (NPS) monitored by the European Monitoring Centre for Drugs and Drug Addiction. Although 3-methylmethcathinone (3-MMC, C11H15NO) is legally banned in many coun...
Development and validation of a sensitive and simultaneous liquid chromatography tandem mass spectrometry method for the determination of eight phytocannabinoids in various CBD products [0.03%]
一种同时测定各种CBD产品中八种植物大麻素的灵敏液相色谱-质谱联用法的发展与验证
Kyosuke Minamoto,Takahiro Takayama,Hidenao Katehashi et al.
Kyosuke Minamoto et al.
In this study, we developed and validated a liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the simultaneous determination of eight phytocannabinoids in various cannabidiol (CBD) products from Japanese market. This meth...
Anti-atherosclerotic effect of tetrahydroxy stilbene glucoside via dual-targeting of hepatic lipid metabolisms and aortic M2 macrophage polarization in ApoE-/- mice [0.03%]
藤黄茋苷通过同时靶向肝脏脂代谢和主动脉M2型巨噬细胞极化抑制ApoE基因敲除小鼠动脉粥样硬化作用的研究
Minghui Li,Yuanyuan Meng,Xuelian Hong et al.
Minghui Li et al.
Tetrahydroxy stilbene glucoside (TSG) is a water-soluble natural product that has shown potential in treating atherosclerosis (AS). However, its underlying mechanisms remain unclear. Here, we demonstrate that an 8-week TSG treatment (100 mg...
A combination of multiple LC-MS approaches for the comprehensive characterization of cysteine-linked ADCs [0.03%]
多种LC-MS方法结合用于半胱氨酸连接的ADCs的全面表征
Gang Wu,Jialiang Du,Meng Li et al.
Gang Wu et al.
Antibody-drug conjugates (ADCs) represent the forefront of the next generation of biopharmaceuticals. An ADC typically comprises an antibody covalently linked to a cytotoxic drug via a linker, resulting in a highly heterogeneous product. Th...
A rapid LC-MS/MS method for the simultaneous quantification of ivacaftor, lumacaftor, elexacaftor, tezacaftor, hexyl-methyl ivacaftor and ivacaftor carboxylate in human plasma [0.03%]
一种快速的LC-MS/MS方法同时定量人血浆中 Ivacaftor、Lumacaftor、Elexacaftor、Tezacaftor、Hexyl-Methyl-Ivacaftor 和 Ivacaftor Carboxylate 的方法
Yi Zheng,Steeve Rouillon,Mohamed Khemakhem et al.
Yi Zheng et al.
Cystic fibrosis is one of the most common genetic diseases among caucasian population. This disease is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene encoding for the CFTR protein. Lumacaftor, ele...
Determination of eleven components in rat plasma by UPLC-MS/MS and GC-MS for pharmacokinetic studies after oral administration of Citri Reticulatae Pericarpium extract [0.03%]
一种橘皮提取物口服给药后血液中11个成分的测定及药代动力学研究
Yameng Zhu,Fanjiao Zuo,Huizi Ouyang et al.
Yameng Zhu et al.
Citri Reticulatae Pericarpium (CRP) is used as common health-care food and traditional Chinese medicine (TCM), which exerts pharmacological effects, such as anti-cardiovascular, anti-tumor, anti-oxidant, anti-inflammatory, anti-virus, hepat...
Measurement of cellular MDA content through MTBE-extraction based TBA assay by eliminating cellular interferences [0.03%]
通过MTBE萃取法消除细胞干扰后测定TBA法测定细胞内MDA含量
Han Wu,Yuwen Kong,Wenjie Zhao et al.
Han Wu et al.
Malondialdehyde (MDA) has long been served as a crucial indicator for assessing cellular oxidative stress levels. In this study, we introduce a new approach to determine cellular MDA levels based on a methyl tert-butyl ether (MTBE) extracti...
Challenges encountered in the enantioselective analysis of new psychoactive substances exemplified by clephedrone (4-CMC) [0.03%]
手性新精神活性物质氯苯他酮（4-氯甲卡西酮）的对映体拆分分析挑战案例研究
Saba Jorbenadze,Tamar Khatiashvili,Lasha Giunashvili et al.
Saba Jorbenadze et al.
In this study we report on efforts to develop an enantioselective method for the detection of the drug of abuse clephedrone (1-(4-chlorophenyl)-2-(methylamino)-1-propanone (4-chloromethcathinone, also known as 4-CMC or para-chloro-methcathi...