A progressive screening strategy by combining UHPLCQTOF-MS and machine learning for distinguishing different varieties of Citri Reticulatae Pericarpium [0.03%]
结合UHPLC-Q-TOF-MS和机器学习的分类单元逐步筛选策略用于不同陈皮品种鉴别的研究
Defang Hu,Minyong Zhong,Zerong Pei et al.
Defang Hu et al.
This study employed UHPLC-QTOF-MS-based untargeted metabolomics, integrated with chemometrics and machine learning, to discriminate between varieties of Citri Reticulatae Pericarpium (CRP). To identify specific markers between each pair of ...
Identification of ursolic acid from Wumei as a syk-targeting anti-allergic agent using a piezoresistive cantilever biosensor [0.03%]
基于压阻式力学生物传感器鉴定五味子中Syk靶向抗过敏成分乌索酸
Zhan Xu,Bin Miao,Zhiqi Gu et al.
Zhan Xu et al.
Wumei (WM), a historical food and medicine homology fruit in China, is reported to have anti-allergic effect, yet its active components and mechanisms remain unclear. Here, a novel spleen tyrosine kinase-based piezoresistive cantilever arra...
Matrix-dependent degradation kinetics and impurity fingerprinting of cannabidiol (CBD) in polymeric and lipid preservation systems [0.03%]
基于矩阵的降解动力学和杂质指纹鉴定聚集体和脂质保鲜系统中的大麻二酚(CBD)
Qurat Ul Ain Haidery,Bo Han,Rashid Saeed et al.
Qurat Ul Ain Haidery et al.
Cannabidiol (CBD), a non-psychoactive terpenophenolic compound derived from Cannabis sativa, exhibits broad-spectrum pharmacological activities but is highly susceptible to oxidative, photolytic, and thermal degradation, making it challengi...
Simultaneous quantification of active ingredients after the combination of Shenqi Fuzheng injection and docetaxel in vitro and in rabbits [0.03%]
参附注射液与多西他赛体外以及在兔体内的复方配伍定量分析研究
Yanqiong Luo,Dan Zeng,Jiawen Liu et al.
Yanqiong Luo et al.
Shenqi Fuzheng injection (SFI), known for its ability to replenish Qi and strengthen vital energy, is frequently combined with docetaxel, a first-line chemotherapeutic agent, for the treatment of breast cancer in clinical practice. Although...
Self-assembled precipitates from Gegen Qinlian decoction: Physicochemical characterization, in vivo and in vitro behaviors [0.03%]
基于葛芩连汤的自组装沉淀物：物理化学性质、体内外行为研究
Zhe Chen,Zhenye Luo,Ting Xia et al.
Zhe Chen et al.
Gegen Qinlian decoction (GQD), a traditional Chinese medicine used to treat infectious diarrhea, forms self-precipitates (GQD-P) during decoction. Although GQD-P and the supernatant (GQD-S) share an identical chemical composition, their phy...
Identification of Novel Anti- non-small cell lung cancer (NSCLC) Peptide in toad Skin（Chan Pi） Extract through Integrated Peptidomics and in silico Screening [0.03%]
基于整合肽组学和计算机辅助筛选蟾皮中抗非小细胞肺癌(NSCLC)多肽的研究
Xiaoxin Tu,Jia Wu,Ying Dong et al.
Xiaoxin Tu et al.
Toad skin (Bufo bufo gargarizans Cantor), known as Chan Pi in traditional Chinese medicine, has long been recognized for its therapeutic potential, particularly in cancer treatment. While the pharmacological activities of small molecules in...
Metabolic disparities of potentially toxic components derived from Psoraleae Fructus and Euodiae Fructus within the Sishen wan influenced by varying compatibilities and physiological conditions in an in vitro gut microbiota model [0.03%]
基于体外肠道菌群模型的补骨脂果实和吴茱萸果实四神丸不同配伍及生理条件下潜在毒性成分的代谢差异性研究
Lili Hong,Lingli Ma,Jiamiao Dong et al.
Lili Hong et al.
Sishen wan (SSW) is utilized in the treatment of irritable bowel syndrome (IBS). This study aimed to compare gut microbiota-mediated metabolic profiles of potential toxicants derived from Psoraleae Fructus (PF) and Euodiae Fructus (EF) in m...
Isolation and identification of the designer benzodiazepine cyclopropylflualprazolam in pressed candies marketed for sleep improvement [0.03%]
从宣称为改善睡眠而销售的压片糖果中分离和鉴定新型合成大麻素HHC-β-CYCLE及精神药物环丙利福拉唑氨酚
Xiaopu Liu,Lihong Zhao,Peizhi Dong et al.
Xiaopu Liu et al.
A novel alprazolam analog was detected as an illegal additive in pressed candies marketed for sleep improvement using high-performance liquid chromatography (HPLC)-diode array detection (DAD). The compound was further isolated and purified ...
E-nose, HS-SPME-GC-MS and untargeted metabolomics reveal effects on 60Co gamma irradiation of Neng-An-Jun-Ning Pills: Changes in odor and chemical compositions [0.03%]
电子鼻、HS-SPME-GC-MS和非靶标代谢组学揭示了~(60)Coγ射线辐照对宁安君宁片的影响：气味及化学成分的变化
Zihong Wang,Juhong An,Renqing Daji et al.
Zihong Wang et al.
Tibetan medicinal preparations are mainly composed of crude medicinal powder, which are susceptible to microbial contamination. Due to its high efficiency and low-treatment characteristics, ⁶⁰Co gamma irradiation is currently the most com...
Polysaccharide-driven quality control of Gastrodia elata Blume: A multidimensional strategy integrating LC-MS/MS-based quantitative analysis, machine learning, and anti-neuroinflammatory bioactivity [0.03%]
基于LC-MS/MS定量分析、机器学习和抗神经炎症生物活性的天麻多糖质量控制：一种多维策略
Xinqin Kong,Sihan Chen,Liling Shen et al.
Xinqin Kong et al.
Gastrodia elata Blume (GE), a highly regarded traditional Chinese medicinal herb, is widely recognized for its diverse pharmacological activities. Current quality control primarily relies on small molecule biomarkers, yet critical research ...