Determination of fifteen compounds in rat plasma by UHPLC-QTRAP-MS/MS for pharmacokinetic study after oral administration of Euonymi herba extract [0.03%]
一种番木通提取物口服给药后 rats 血浆中15种化合物的UHPLC-QTRAP-MS/MS法及其药动学研究
Fanjiao Zuo,Peng Zhao,Xueyu Liu et al.
Fanjiao Zuo et al.
Euonymi herba (EH) was one of the traditional characteristic national medicines of Guangxi, which had various pharmacological activities such as hemostasis, anti-myocardial hypoxia, and anti-aging. This study established a reliable ultra-hi...
Investigation of the stability profile of therapeutic α-MSH analogue: Insights from liquid chromatography-high resolution mass spectrometry analysis of afamelanotide [0.03%]
治疗性α-MSH类似物仿制药稳定性研究：高分辨率液相色谱质谱法测定Afamelanotide的杂质剖面图分析方法开发及应用 investigación
Ashwini Chawathe,Nitish Sharma
Ashwini Chawathe
Afamelanotide, also known as melanotan-1, is a synthetic 13-amino acid peptidomimetic of α-melanocyte stimulating hormone (α-MSH), and is a critical peptide orphan drug used for the management of erythropoietic protoporphyria. It contains...
Unraveling excretion behavior of polyethylene glycol 1000 with 13-26 subunits in rats by UHPLC-MS/MS [0.03%]
超高效液相色谱-多级质谱法研究大鼠体内聚乙二醇1000的13-26亚基排泄行为
Xiaoyan Zhang,Shuang Feng,Ziluo Zhang et al.
Xiaoyan Zhang et al.
This study established a robust and selective ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method to investigate the excretion behavior of polyethylene glycol 1000 (PEG1K) oligomers (N = 13-26) in rats...
Integrated dual-molecular marker analysis with SSR and UPLC-Q-TOF/MS fingerprints technology reveal the interrelation of the molecule-metabolite in Morus alba L. leaves [0.03%]
基于SSR和UPLC-Q-TOF/MS指纹图谱的双分子标记分析揭示了桑叶中的分子-代谢物关系
Yuqing Tian,Pei Ma,Liang Wang et al.
Yuqing Tian et al.
Morus alba L. (M. alba) leaves, valued for their medicinal and edible properties, possess substantial economic and social importance. Notably, diverse germplasm resources of M. alba exhibit considerable variation in both metabolite composit...
Identification of metabolites from the Himalayan herbal medicine Meconopsis integrifolia total flavonoids fraction in rats using UPLC-Q-exactive orbitrap-MS analysis [0.03%]
基于UPLC-Q-Exactive Orbitrap-MS分析技术的药用植物须弥芥总黄酮代谢产物研究
Enhui Ji,Yuan Liu,Yifan Tian et al.
Enhui Ji et al.
Meconopsis integrifolia total flavonoids (MITF) have been identified as the hepatoprotective fraction of M. integrifolia, with its main components being flavonoid glycosides, along with lower levels of phenolic acids and alkaloids. Since fl...
Exploring the therapeutic potential of Anoectochilus roxburghii in glucose and lipid metabolism disorder: From phenotypic effects to molecular mechanisms and network pharmacology [0.03%]
独荇草治疗糖脂代谢紊乱的疗效初探：从表型到分子机制及网络药理学研究
Wei Li,Yaqian Cheng,Tong Wu et al.
Wei Li et al.
Dysregulation of glucose and lipid metabolism has emerged as a leading cause of cardiovascular diseases worldwide. The current treatment for these diseases is often a combination of drugs. Despite the preference efficacy of combination ther...
A standard-free strategy for the differentiation of isomers and deep profiling of chemicalome in Chinese medicinal formulas [0.03%]
无标准品中药复方配方等位异构体的分离及化学组深度剖析的策略研究
Ying-Shan Li,Xing-Ting Dong,Gui-Zhong Xin et al.
Ying-Shan Li et al.
The precise differentiation of isomers is crucial for comprehensive mass spectrometry-based analysis of complex Chinese medicinal formulas (CMFs). To address this challenge, a standard-free strategy was proposed by integrating chromatograph...
Revolutionizing ELISA development: The transformative impact of automation on monoclonal antibody potency assays [0.03%]
自动化对单克隆抗体效价测定的变革影响：革命化ELISA开发
Xiaoran Xin,Douglas Pung,Amy Hsu et al.
Xiaoran Xin et al.
Enzyme-linked immunosorbent assays (ELISA) are a fundamental technique for determining the potency of monoclonal antibodies (mAbs), yet the traditional ELISA development process is often time-consuming and labor-intensive. In this study, we...
Development of a simple labeling method using fluorescent protein fusion proteins targeting the membrane lipids of small extracellular vesicles [0.03%]
开发一种使用荧光蛋白融合蛋白针对小型细胞外囊泡膜脂质的简单标记方法
Yuki Kobayashi,Yuki Takahashi,Hiroto Otera et al.
Yuki Kobayashi et al.
Extracellular vesicles (EV) are lipid-based nanoparticles naturally released by cells, exhibiting considerable heterogeneity in size, surface charge, and biomolecular composition. Recently, increasing attention has been directed toward the ...
Ease of analysis through unification: One gas chromatographic method for the chemical profiling of essential oils [0.03%]
一体化分析的简便性：一种用于精油化学特征分析的气相色谱法
Dominik Kresnik,Bryan Bajor,Christian Steuer
Dominik Kresnik
The rising interest in essential oils (EOs) for their therapeutic, antibacterial, and antifungal properties has led to an increasing demand for high-quality products in both medicinal and industrial sectors. To meet these stringent quality ...