Rapid, precise and multi-excipient benchtop 1H NMR method to monitor drug substance and drug product process consistency [0.03%]
Kyle Esposito,Adam T Sutton,Richard R Rustandi et al.
Kyle Esposito et al.
Vaccine and biologic manufacturing processes and formulations include a series of purification, filtration, and buffer exchanges. The complexity associated with these processes is increased with drug product images or multiple component dru...
Environmental sustainability assessment of reverse-phase liquid chromatography for retention and ionization profiling of angiotensin-converting enzyme inhibitors [0.03%]
Erdem Kuzucanlı,Ebru Çubuk Demiralay,Yaşar Doğan Daldal et al.
Erdem Kuzucanlı et al.
This paper presents a sustainable chromatographic framework using reverse-phase liquid chromatography (RPLC) method with an ultraviolet detector (UV) to determine the ionization behavior of three angiotensin-converting enzyme (ACE) inhibito...
A distinct plasma lipidomic signature and multi-omics network in depression of polycystic ovary syndrome [0.03%]
Furong Yan,Ming Sui,Hongzhi Gao et al.
Furong Yan et al.
Patients with polycystic ovary syndrome (PCOS) are at an elevated risk of depression, yet the underlying mechanisms remain elusive. Emerging evidence implicates the gut-brain axis and systemic lipid homeostasis alterations as potential key ...
NMR-based serum metabolomics reveals diabetes-linked metabolic reprogramming in early-stage chronic kidney disease [0.03%]
Upasna Gupta,Amrita Sahu,Anupama Kaul et al.
Upasna Gupta et al.
Early-stage chronic kidney disease (CKD) is usually asymptomatic, and the presence of type 2 diabetes mellitus (T2DM) accelerates metabolic alterations long before conventional clinical markers detect changes. Despite their strong clinical ...
Simultaneous analysis of various anticancer drugs by supercritical fluid chromatography-mass spectrometry. Part II: Method validation and comparison with liquid chromatography [0.03%]
Virginie Vallet,Nathalie Nguyen,Serge Rudaz et al.
Virginie Vallet et al.
A complete SFC-MS/MS method validation enabling the simultaneous trace-level analysis of 27 conventional anticancer drugs (CADs) was performed. The selected drugs were the following: 5-fluorouracil, azacitidine, busulfan, carboplatin, cispl...
First enantioselective determination of N-ethylpentedrone and its major phase-1 metabolites using supercritical fluid chromatography coupled with tandem mass spectrometry and its application to human oral fluid and urine samples [0.03%]
Saba Jorbenadze,Aluda Tchelidze,Giorgia Sprega et al.
Saba Jorbenadze et al.
The enantioselective bioanalysis of synthetic cathinones and their metabolites remains analytically challenging. Due to the basic nature of these compounds, mobile phases with elevated pH are preferable for their analysis in high-performanc...
Optimized UHPLC-derivatization method for low-level nitrite detection in pharmaceutical excipients [0.03%]
Róbert Kormány
Róbert Kormány
This work presents a method optimization strategy for determining nitrite ions in pharmaceutical excipients. After derivatization, nitrite ions were analyzed using ultra-high-pressure liquid chromatography with UV detection. The article det...
Microstructural analysis of PLGA-PEG-PLGA copolymer based on NMR spectroscopy using model compounds [0.03%]
Bartosz Strus,Jerzy Sitkowski,Arkadiusz Szterk
Bartosz Strus
This study presents a novel strategy for studying the microstructure of PLGA-PEG-PLGA triblock copolymers synthesized via the ROP mechanism using various organic catalysts. The use of model copolymers (PLG-PEG-PLG, PLA-PEG-PLA) and multidim...
A universal immunocapture LC-MS/MS method for humanized IgG1-based drugs in cynomolgus monkeys [0.03%]
Pei Pang,Pingping Yin,Yimin Tao et al.
Pei Pang et al.
The application of immunocapture LC-MS/MS in drug testing has expanded considerably over the past decade, offering significant advantages in analysis, development, and identification. In this study, we developed and validated a universal im...
Pharmacokinetic-pharmacodynamic modeling of Laportea bulbifera extract in adjuvant-induced arthritis rats via joint cavity microdialysis [0.03%]
Siying Chen,Dan Lu,Kang Yang et al.
Siying Chen et al.
This study developed a local pharmacokinetic-pharmacodynamic (PK-PD) model for Laportea bulbifera extract (LBE) in the joint cavity of adjuvant-induced arthritis (AA) rats using microdialysis technology. A stable intra-articular microdialys...