Can the new adipokine asprosin be a metabolic troublemaker for cardiovascular diseases? A state-of-the-art review [0.03%]
新型脂肪细胞因子asprosin或成为心血管疾病的代谢不良因素？最新综述
Zhengbin Zhang,Liwen Zhu,Ziqian Wang et al.
Zhengbin Zhang et al.
Adipokines play a significant role in cardiometabolic diseases. Asprosin, a newly discovered adipokine, was first identified as a glucose-raising protein hormone. Asprosin also stimulates appetite and regulates glucose and lipid metabolism....
Endocannabinoid signaling in adult hippocampal neurogenesis: A mechanistic and integrated perspective [0.03%]
成人海马神经发生中的内源大麻素信号：机制和整体视角
Sergio Oddi,Maria Teresa Fiorenza,Mauro Maccarrone
Sergio Oddi
Dentate gyrus of the hippocampus continuously gives rise to new neurons, namely, adult-born granule cells, which contribute to conferring plasticity to the mature brain throughout life. Within this neurogenic region, the fate and behavior o...
Lipidomics in pathogenesis, progression and treatment of nonalcoholic steatohepatitis (NASH): Recent advances [0.03%]
脂质组学在非酒精性脂肪肝病发生、发展及治疗中的作用:最新研究进展
Giovanni Musso,Francesca Saba,Maurizio Cassader et al.
Giovanni Musso et al.
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease affecting up to 30% of the general adult population. NAFLD encompasses a histological spectrum ranging from pure steatosis to non-alcoholic steatohepatitis (NASH). NASH can...
Archaeal lipids [0.03%]
古菌脂类
Tomáš Řezanka,Lucie Kyselová,Denis J Murphy
Tomáš Řezanka
The major archaeal membrane glycerolipids are distinguished from those of bacteria and eukaryotes by the contrasting stereochemistry of their glycerol backbones, and by the use of ether-linked isoprenoid-based alkyl chains rather than ester...
The pathophysiological role of dihydroceramide desaturase in the nervous system [0.03%]
神经系统的二氢脑苷单加氧酶病理生理作用
Fei-Yang Tzou,Thorsten Hornemann,Jui-Yu Yeh et al.
Fei-Yang Tzou et al.
Dihydroceramide desaturase 1 (DEGS1) converts dihydroceramide (dhCer) to ceramide (Cer) by inserting a C4-C5 trans (∆4E) double bond into the sphingoid backbone. Low DEGS activity causes accumulation of dhCer and other dihydrosphingolipid ...
Volodymyr Petrenko,Flore Sinturel,Howard Riezman et al.
Volodymyr Petrenko et al.
Lipids play important roles in energy metabolism along with diverse aspects of biological membrane structure, signaling and other functions. Perturbations of lipid metabolism are responsible for the development of various pathologies compri...
Systematic crosstalk in plasmalogen and diacyl lipid biosynthesis for their differential yet concerted molecular functions in the cell [0.03%]
系统调控鞘磷脂和二酰基脂质生物合成以实现其在细胞中的差异化协同分子功能
Tomohiro Kimura,Atsuko K Kimura,Richard M Epand
Tomohiro Kimura
Plasmalogen is a major phospholipid of mammalian cell membranes. Recently it is becoming evident that the sn-1 vinyl-ether linkage in plasmalogen, contrasting to the ester linkage in the counterpart diacyl glycerophospholipid, yields differ...
Mammalian lipid droplets: structural, pathological, immunological and anti-toxicological roles [0.03%]
哺乳动物脂滴：结构、病理、免疫和抗毒性作用
Nour Hammoudeh,Chadi Soukkarieh,Denis J Murphy et al.
Nour Hammoudeh et al.
Mammalian lipid droplets (LDs) are specialized cytosolic organelles consisting of a neutral lipid core surrounded by a membrane made up of a phospholipid monolayer and a specific population of proteins that varies according to the location ...
Monomethyl branched-chain fatty acids: Health effects and biological mechanisms [0.03%]
单甲基支链脂肪酸：健康影响及生物学机制
Paulina Gozdzik,Faidon Magkos,Tomasz Sledzinski et al.
Paulina Gozdzik et al.
Branched-chain fatty acids (BCFA) are a group of lipids that are widely present in various organisms; they take part in numerous biochemical processes and affect multiple signaling pathways. However, BCFA are not well explored in terms of t...
The Niemann-Pick type diseases - A synopsis of inborn errors in sphingolipid and cholesterol metabolism [0.03%]
尼曼匹克症候群-鞘脂与胆固醇代谢先天性异常之概述
Frank W Pfrieger
Frank W Pfrieger
Disturbances of lipid homeostasis in cells provoke human diseases. The elucidation of the underlying mechanisms and the development of efficient therapies represent formidable challenges for biomedical research. Exemplary cases are two rare...