Metabolic fate of saturated and monounsaturated dietary fats: the Mediterranean diet revisited from epidemiological evidence to cellular mechanisms [0.03%]
饱和和单不饱和膳食脂肪的代谢命运：从流行病学证据到细胞机制再探地中海饮食
Audrey Bergouignan,Iman Momken,Dale A Schoeller et al.
Audrey Bergouignan et al.
Increasing evidence indicates favourable effects of the Mediterranean diet, partly associated to its monounsaturated fatty acids (MUFA) content on both obesity and diabetes. However, neither the underlying mechanisms by which the Mediterran...
Alexandra Andreou,Florian Brodhun,Ivo Feussner
Alexandra Andreou
Lipid peroxidation is common to all biological systems, appearing in developmentally-regulated processes and as a response to environmental changes. Products derived from lipid peroxidation are collectively named oxylipins. Initial lipid pe...
Tsuyoshi Iwanaga,Ryouhei Tsutsumi,Jun Noritake et al.
Tsuyoshi Iwanaga et al.
Protein S-palmitoylation, the most common lipid modification with the 16-carbon fatty acid palmitate, provides an important mechanism for regulating protein trafficking and function. The unique reversibility of protein palmitoylation allows...
Structuring food emulsions in the gastrointestinal tract to modify lipid digestion [0.03%]
胃肠乳化剂结构设计及其对脂质消化的影响
Harjinder Singh,Aiqian Ye,David Horne
Harjinder Singh
The importance of nutrient lipids in the human diet has led to major advances in understanding the mechanisms of lipid digestion and absorption. With these advances has come new recognition that the matrix in which lipids are presented (i.e...
The evolution of plasma cholesterol: direct utility or a "spandrel" of hepatic lipid metabolism? [0.03%]
胆固醇的进化：直接有益还是肝脏脂质代谢的“副产品”？
Patrick J Babin,Geoffrey F Gibbons
Patrick J Babin
Fats provide a concentrated source of energy for multicellular organisms. The efficient transport of fats through aqueous biological environments raises issues concerning effective delivery to target tissues. Furthermore, the utilization of...
Asim K Duttaroy
Asim K Duttaroy
Essential fatty acids and their long chain polyunsaturated fatty acid derivatives (20C) such as docosahexaenoic and arachidonic acids are critical for proper fetal growth and development. Dietary intake as well as metabolism of these fatty ...
Ulf Risérus,Walter C Willett,Frank B Hu
Ulf Risérus
Although type 2 diabetes is determined primarily by lifestyle and genes, dietary composition may affect both its development and complications. Dietary fat is of particular interest because fatty acids influence glucose metabolism by alteri...
Metabolism of sphingolipids in the gut and its relation to inflammation and cancer development [0.03%]
肠道鞘脂代谢及其与炎症和癌症发生的关系
Rui-Dong Duan,Ake Nilsson
Rui-Dong Duan
Sphingolipids are abundant in the microvillar membrane of intestinal epithelial cells where they are essential for structural integrity and may act as receptors for toxins, virus and bacteria. Metabolism of dietary and membrane sphingolipid...
Innate immune mechanisms linking non-esterified fatty acids and respiratory disease [0.03%]
非酯化脂肪酸与呼吸道疾病之间的固有免疫机制联系
Lisa G Wood,Hayley A Scott,Manohar L Garg et al.
Lisa G Wood et al.
Local airway inflammation in chronic respiratory disease is well described. Recently it has been recognised that chronic obstructive respiratory disease, asthma and obstructive sleep apnoea, all involve a systemic inflammatory component. Ov...
Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD) [0.03%]
非酒精性脂肪肝病（NAFLD）肝脏脂质代谢的最新见解
Giovanni Musso,Roberto Gambino,Maurizio Cassader
Giovanni Musso
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries and is considered the hepatic manifestation of metabolic syndrome. The hallmark of NAFLD is hepatic neutral lipid accumulation, mainly tr...