N-Acylethanolamines in cancer: mechanisms and therapeutic potential of lipid regulators of tumor behavior [0.03%]
脂肪调节剂在癌症中的作用机制及其治疗潜能
M F Nanì,M M Rinaldi,M Miraglia et al.
M F Nanì et al.
N-Acylethanolamines (NAEs) are endogenous bioactive lipids generated from membrane glycerophospholipids, with key members including arachidonoylethanolamide (anandamide, AEA), oleoylethanolamide (OEA), and palmitoylethanolamide (PEA). These...
Yukihiko Sugimoto,Shizu Aikawa,Tomoaki Inazumi et al.
Yukihiko Sugimoto et al.
Embryo implantation and subsequent decidualization are crucial processes for the establishment of a healthy pregnancy, but the molecular mechanisms underlying these processes remain unclear. Prostaglandins (PGs), which are synthesized from ...
Omega-3 polyunsaturated fatty acids in neurodegenerative disorders: Mixed designs = mixed results [0.03%]
欧米伽3多不饱和脂肪酸与神经退行性疾病：混合研究设计得出的结论莫衷一是
Simon C Dyall,Mélanie Plourde
Simon C Dyall
Epidemiological studies consistently show an elevated intake of fish and long-chain omega-3 polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), reduces the risk of developing neurodegener...
Homeocurvature: A new dimension of membrane adaptation to extreme environments [0.03%]
极端环境下的膜适应新维度：โฮモエカRVATURE
Jacob R Winnikoff,Itay Budin
Jacob R Winnikoff
Adaptation to abiotic factors is essential for life's radiation across the planet. Lipids, particularly sensitive to pressure and temperature (P and T), play a critical role in biochemical adaptation. In oceanic depths, lower temperatures a...
Different chains for different gains: How acyl chain diversity shapes S-acylated protein function [0.03%]
不同的脂肪链产生不同的功能效益：酰基链多样性如何影响蛋白的棕榈酰化功能
Carla Busquets Hernández,Alexandra Tsiotsia,Ludovico Pipitò et al.
Carla Busquets Hernández et al.
S-Acylation is a critical post-translational modification involving the attachment of fatty acyl chains to a large and diverse array of soluble and membrane proteins. The last two decades have witnessed a substantial acceleration in our und...
Targeting fatty acid-binding protein 4: A therapeutic intersection of obesity and cancer via lipid metabolism [0.03%]
靶向长链脂肪酸结合蛋白4：肥胖和癌症中的代谢治疗途径
Katarzyna Smolińska,Aleksandra Szopa,Piotr Dobrowolski et al.
Katarzyna Smolińska et al.
Fatty acid-binding protein 4 (FABP4) has emerged as a multifunctional regulator in cancer biology, linking dysregulated lipid metabolism, immune modulation, and tumor progression. Initially recognized for its role in fatty acid transport an...
Apolipoproteins in circulation: At the interface of thrombosis and stroke initiation [0.03%]
循环中的载脂蛋白：在血栓形成和卒中起始的交汇处
Tamara Etuze,Denis Vivien,Fatemeh Dubois
Tamara Etuze
Ischemic stroke, a leading cause of death and disability worldwide, arises predominantly from atherosclerosis and thromboembolic occlusion of cerebral arteries. While advancements in acute interventions such as thrombolysis and thrombectomy...
The endocannabinoid system & malignant hyperthermia: From molecular signaling towards clinical implications [0.03%]
内源大麻素系统与恶性高热：从分子信号转导到临床意义
Simon Dalle,Sebastiaan Dalle
Simon Dalle
Malignant hyperthermia (MH) is a life-threatening pharmacogenetic disorder triggered by volatile anaesthetics and depolarizing muscle relaxants. MH is characterized by excessive calcium release from the sarcoplasmic reticulum, often due to ...
The balancing act between lipid droplets and lysosomes for membrane functionality in age-related neurodegeneration and inflammation [0.03%]
脂滴和溶酶体在年龄相关神经退行性病变和炎症中的膜功能平衡调控作用
Mariana I Tsap,Halyna R Shcherbata
Mariana I Tsap
Age-related neurodegenerative disorders are often associated with disruptions in lipid metabolism. A critical aspect is the impairment of the interaction between lipid droplets (LDs) and lysosomal function, leading to the accumulation of to...
Phospholipids and their metabolites as diagnostic biomarkers of human diseases [0.03%]
磷脂及其代谢产物作为人类疾病的诊断生物标志物
Jeong-Hun Kang,Riki Toita,Takahito Kawano et al.
Jeong-Hun Kang et al.
Phospholipids that occur predominantly in the plasma membrane of mammalian cells are phosphatidylcholine (PC), phosphatidylserine (PS), phosphatidylethanolamine (PE), sphingomyelin (SM), and phosphatidylinositol (or phosphoinositide; PI). T...