Fatty acids and evolving roles of their proteins in neurological, cardiovascular disorders and cancers [0.03%]
脂肪酸及其蛋白质在神经、心血管疾病和癌症中的作用及演变
Rahul Mallick,Sanjay Basak,Asim K Duttaroy
Rahul Mallick
The dysregulation of fat metabolism is involved in various disorders, including neurodegenerative, cardiovascular, and cancers. The uptake of long-chain fatty acids (LCFAs) with 14 or more carbons plays a pivotal role in cellular metabolic ...
Regulation of EGFR activation and signaling by lipids on the plasma membrane [0.03%]
细胞膜脂质对EGFR活化和信号传导的调节作用
Do-Hyeon Kim,Hong Minh Triet,Sung Ho Ryu
Do-Hyeon Kim
Lipids on the plasma membrane are not only components of the membrane biophysical structures but also regulators of receptor functions. Recently, the critical roles of lipid-protein interactions have been intensively highlighted. Epidermal ...
Imaging lipids in biological samples with surface-assisted laser desorption/ionization mass spectrometry: A concise review of the last decade [0.03%]
表面辅助激光解吸电离质谱在生物样本脂质成像中的应用：过去十年的综述
Wendy H Müller,Edwin De Pauw,Johann Far et al.
Wendy H Müller et al.
Knowing the spatial location of the lipid species present in biological samples is of paramount importance for the elucidation of pathological and physiological processes. In this context, mass spectrometry imaging (MSI) has emerged as a po...
Potential modulatory mechanisms of action by long-chain polyunsaturated fatty acids on bone cell and chondrocyte metabolism [0.03%]
长链多不饱和脂肪酸对骨细胞和软骨细胞代谢作用的潜在调节机制
Maryam Abshirini,Bolaji Lilian Ilesanmi-Oyelere,Marlena C Kruger
Maryam Abshirini
Long-chain polyunsaturated fatty acids (LCPUFAs) and their metabolites are considered essential factors to support bone and joint health. The n-6 PUFAs suppress the osteoblasts differentiation via increasing peroxisome proliferator-activate...
Phosphatidylserine-specific phospholipase A1: A friend or the devil in disguise [0.03%]
磷脂酶A1：有益的帮手还是潜在的恶魔？
Yang Zhao,Stephan Hasse,Sylvain G Bourgoin
Yang Zhao
Various human tissues and cells express phospholipase A1 member A (PLA1A), including the liver, lung, prostate gland, and immune cells. The enzyme belongs to the pancreatic lipase family. PLA1A specifically hydrolyzes sn-1 fatty acid of pho...
Plasmalogens - Ubiquitous molecules occurring widely, from anaerobic bacteria to humans [0.03%]
卵磷脂葡萄糖基甘油酯：从厌氧细菌到人类广泛存在的普遍物质
Milada Vítová,Andrea Palyzová,Tomáš Řezanka
Milada Vítová
Plasmalogens are a group of lipids mainly found in the cell membranes. They occur in anaerobic bacteria and in some protozoa, invertebrates and vertebrates, including humans. Their occurrence in plants and fungi is controversial. They can p...
Molecular insights into lipoxygenases for biocatalytic synthesis of diverse lipid mediators [0.03%]
脂氧合酶的分子见解在生物催化合成多种脂质介质中的应用
Jung-Ung An,Seong-Eun Kim,Deok-Kun Oh
Jung-Ung An
Oxylipins derived mainly from C20- and C22-polyunsaturated fatty acids (PUFAs), termed lipid mediators (LMs), are essential signalling messengers involved in human physiological responses associated with homeostasis and healing process for ...
Hepatic cholesterol transport and its role in non-alcoholic fatty liver disease and atherosclerosis [0.03%]
胆汁胆固醇运输及其在非酒精性脂肪肝病和动脉粥样硬化中的作用
Heng Li,Xiao-Hua Yu,Xiang Ou et al.
Heng Li et al.
Non-alcoholic fatty liver disease (NAFLD) is a quickly emerging global health problem representing the most common chronic liver disease in the world. Atherosclerotic cardiovascular disease represents the leading cause of mortality in NAFLD...
Lipid homeostasis and mevalonate pathway in COVID-19: Basic concepts and potential therapeutic targets [0.03%]
冠状病毒病(COVID-19)中的脂质稳态和甲羟戊酸途径：基本概念与潜在治疗靶点
Maria Chiara Proto,Donatella Fiore,Chiara Piscopo et al.
Maria Chiara Proto et al.
Despite encouraging progresses achieved in the management of viral diseases, efficient strategies to counteract infections are still required. The current global challenge highlighted the need to develop a rapid and cost-effective strategy ...
Regulation of hippocampal synaptic function by the metabolic hormone leptin: Implications for health and disease [0.03%]
代谢激素瘦素对海马突触功能的调节：健康和疾病的意义
Andrew Irving,Jenni Harvey
Andrew Irving
Significant advances have been made in our understanding of the hormone, leptin and its CNS actions in recent years. It is now evident that leptin has a multitude of brain functions, that extend beyond its established role in the hypothalam...