Too complex to fail? Targeting fatty acid metabolism for cancer therapy [0.03%]
过于复杂而不能失败？针对脂肪酸代谢进行癌症治疗
Rimsha Munir,Jan Lisec,Johannes V Swinnen et al.
Rimsha Munir et al.
Given the central role of fatty acids in cancer pathophysiology, the exploitation of fatty acid metabolism as a potential antineoplastic therapy has gained much attention. Several natural and synthetic compounds targeting fatty acid metabol...
Bill Lands
Bill Lands
This review examines lipids and lipid-binding sites on proteins in relation to cardiovascular disease. Lipid nutrition involves food energy from ingested fatty acids plus fatty acids formed from excess ingested carbohydrate and protein. Non...
Mapping the myristoylome through a complete understanding of protein myristoylation biochemistry [0.03%]
通过全面了解蛋白质肉豆蔻酰化生物化学来绘制肉豆蔻酰组地图
Carmela Giglione,Thierry Meinnel
Carmela Giglione
Protein myristoylation is a C14 fatty acid modification found in all living organisms. Myristoylation tags either the N-terminal alpha groups of cysteine or glycine residues through amide bonds or lysine and cysteine side chains directly or...
Hello from the other side: Membrane contact of lipid droplets with other organelles and subsequent functional implications [0.03%]
来自另一边的问候：脂滴与其他细胞器的膜接触及其功能影响
Rebekah Rakotonirina-Ricquebourg,Vítor Costa,Vitor Teixeira
Rebekah Rakotonirina-Ricquebourg
Lipid droplets (LDs) are ubiquitous organelles that play crucial roles in response to physiological and environmental cues. The identification of several neutral lipid synthesizing and regulatory protein complexes have propelled significant...
An updated ANGPTL3-4-8 model as a mechanism of triglyceride partitioning between fat and oxidative tissues [0.03%]
作为脂肪组织和氧化组织之间甘油三酯分布机制的更新版ANGPTL3-4-8模型
Ren Zhang,Kezhong Zhang
Ren Zhang
In mammals, triglyceride (TG), the main form of lipids for storing and providing energy, is stored in white adipose tissue (WAT) after food intake, while during fasting it is routed to oxidative tissues (heart and skeletal muscle) for energ...
Plant monounsaturated fatty acids: Diversity, biosynthesis, functions and uses [0.03%]
植物单不饱和脂肪酸：多样性、生物合成、功能及用途
Sami Kazaz,Romane Miray,Loïc Lepiniec et al.
Sami Kazaz et al.
Monounsaturated fatty acids are straight-chain aliphatic monocarboxylic acids comprising a unique carbon‑carbon double bond, also termed unsaturation. More than 50 distinct molecular structures have been described in the plant kingdom, and...
Biophysical insights into modulating lipid digestion in food emulsions [0.03%]
食品乳化液中脂质消化的生物物理见解及其调控机制
Alejandra Acevedo-Fani,Harjinder Singh
Alejandra Acevedo-Fani
During the last decade, major scientific advances on understanding the mechanisms of lipid digestion and metabolism have been made, with a view to addressing health issues (such as obesity) associated with overconsumption of lipid-rich and ...
Making extra room for carotenoids in plant cells: New opportunities for biofortification [0.03%]
在植物细胞中为类胡萝卜素腾出更多空间：生物强化的新机遇
Salvador Torres-Montilla,Manuel Rodriguez-Concepcion
Salvador Torres-Montilla
Plant carotenoids are essential for photosynthesis and photoprotection and provide colors in the yellow to red range to non-photosynthetic organs such as petals and ripe fruits. They are also the precursors of biologically active molecules ...
A comprehensive review on the lipid and pleiotropic effects of pitavastatin [0.03%]
匹伐他汀的血脂和多效作用的全面综述
Amirhossein Sahebkar,Nasim Kiaie,Armita Mahdavi Gorabi et al.
Amirhossein Sahebkar et al.
The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, or statins, are administered as first line therapy for hypercholesterolemia, both in primary and secondary prevention. There is a growing body of evidence showing tha...
Magdolna Szántó,Rebecca Gupte,W Lee Kraus et al.
Magdolna Szántó et al.
PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases were originally identified as DNA repair factors, nevertheless, recent advances have shed light on their role in lipid metabolism. To date, PARP1, PARP2, PA...