Acyl-CoA:diacylglycerol acyltransferase: Properties, physiological roles, metabolic engineering and intentional control [0.03%]
酰基载体蛋白：二脂酰甘油酰基转移酶：性质、生理作用、代谢工程及调控机制研究进展
Guanqun Chen,John L Harwood,M Joanne Lemieux et al.
Guanqun Chen et al.
Acyl-CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) catalyzes the last reaction in the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG). DGAT activity resides mainly in DGAT1 and DGAT2 in eukaryotes and bifunctional wax este...
Lucie Kyselová,Milada Vítová,Tomáš Řezanka
Lucie Kyselová
Very long chain fatty acids (VLCFAs) are important components of various lipid classes in most organisms, from bacteria to higher plants and mammals, including humans. VLCFAs, or very long chain polyunsaturated fatty acids (VLCPUFAs), can b...
Intestinal fatty acid binding protein: A rising therapeutic target in lipid metabolism [0.03%]
肠道脂肪酸结合蛋白：脂质代谢治疗靶点新星闪烁
Xi Huang,Youci Zhou,Yunwei Sun et al.
Xi Huang et al.
Fatty acid binding proteins (FABPs) are key proteins in lipid transport, and the isoforms are segregated according to their tissue origins. Several isoforms, such as adipose-FABP and epidermal-FABP, have been shown to participate in multipl...
Challenges and opportunities for prevention and removal of unwanted variation in lipidomic studies [0.03%]
脂质组学研究中减少和剔除非理想变异的挑战与机遇
Gavriel Olshansky,Corey Giles,Agus Salim et al.
Gavriel Olshansky et al.
Large 'omics studies are of particular interest to population and clinical research as they allow elucidation of biological pathways that are often out of reach of other methodologies. Typically, these information rich datasets are produced...
V K Sharma,E Mamontov
V K Sharma
The plasma membrane is one of the principal structural components of the cell and, therefore, one of the key components of the cellular life. Because the membrane's dynamics links the membrane's structure and function, the complexity and th...
Understanding the nitrolipidome: From chemistry to mass spectrometry and biological significance of modified complex lipids [0.03%]
了解硝基脂质组学：从化学到质谱及修饰复杂脂质的生物学意义
Bruna Neves,Dolores Pérez-Sala,Helena Beatriz Ferreira et al.
Bruna Neves et al.
Complex lipids, phospholipids (PLs) and triacylglycerides (TAGs), are prone to modifications induced by reactive nitrated species and reactive oxygen species, generating a range of nitrated, nitrosated or nitroxidized derivatives, as nitro ...
The constellation of cholesterol-dependent processes associated with SARS-CoV-2 infection [0.03%]
与SARS-CoV-2感染相关的胆固醇依赖性过程的构成星座
Francisco J Barrantes
Francisco J Barrantes
The role of cholesterol in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronavirus-host cell interactions is currently being discussed in the context of two main scenarios: i) the presence of the neutral lipid in ...
Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions [0.03%]
多不饱和脂肪酸及其衍生物近期研究进展：生物合成、结构与功能
Simon C Dyall,Laurence Balas,Nicolas G Bazan et al.
Simon C Dyall et al.
Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids, and influence cellular function via effects on membrane properties, and also by acting as a precursor pool for lipid mediators. These lipid mediators a...
Genetic variation and intestinal cholesterol absorption in humans: A systematic review and a gene network analysis [0.03%]
人类遗传变异与肠道胆固醇吸收的系统评价及基因网络分析
Fatma B A Mokhtar,Jogchum Plat,Ronald P Mensink
Fatma B A Mokhtar
Intestinal cholesterol absorption varies widely between individuals, which may translate into differences in responsiveness to cholesterol-lowering drugs or diets. Therefore, understanding the importance of genetic variation on cholesterol ...
Structural and functional roles of non-bilayer lipid phases of chloroplast thylakoid membranes and mitochondrial inner membranes [0.03%]
叶绿体类囊体膜和线粒体内膜非双层脂质相的结构与功能作用
Győző Garab,Lev S Yaguzhinsky,Ondřej Dlouhý et al.
Győző Garab et al.
The 'standard' fluid-mosaic membrane model can provide a framework for the operation of the photosynthetic and respiratory electron transport systems, the generation of the proton motive force (pmf) and its utilization for ATP synthesis acc...