Peter Kohl,T Alexander Quinn
Peter Kohl
EAD and DAD mechanisms analyzed by developing a new human ventricular cell model [0.03%]
通过开发新的心室细胞模型来分析EAD和DAD机制
K Asakura,C Y Cha,H Yamaoka et al.
K Asakura et al.
It has long been suggested that the Ca(2+)-mechanisms are largely involved in generating the early afterdepolarization (EAD) as well as the delayed afterdepolarization (DAD). This view was examined in a quantitative manner by applying the l...
Sebastien G M Uzel,Andrea Pavesi,Roger D Kamm
Sebastien G M Uzel
The relatively recent development of microfluidic systems with wide-ranging capabilities for generating realistic 2D or 3D systems with single or multiple cell types has given rise to an extensive collection of platform technologies useful ...
NMR approaches in structure-based lead discovery: recent developments and new frontiers for targeting multi-protein complexes [0.03%]
基于结构的先导化合物发现中的核磁共振方法：针对多蛋白复合物的新前沿和最近进展
David M Dias,Alessio Ciulli
David M Dias
Nuclear magnetic resonance (NMR) spectroscopy is a pivotal method for structure-based and fragment-based lead discovery because it is one of the most robust techniques to provide information on protein structure, dynamics and interaction at...
Amit Livneh,Eitan Kimmel,Andrew R Kohut et al.
Amit Livneh et al.
Ultrasound has been shown to produce Premature Ventricular Contractions (PVC's). Two clinical applications in which acute cardiac pacing by ultrasound may be valuable are: (1) preoperative patient screening in cardiac resynchronization ther...
Personalized metabolic profile estimations using oral glucose tolerance tests [0.03%]
基于口服葡萄糖耐量试验的代谢指标个性化预测模型
Young Boum Lee,Jeong Hoon Lee,Eun Seok Park et al.
Young Boum Lee et al.
Background & objectives: Oral glucose tolerance tests (OGTTs) are used commonly to diagnose diabetes mellitus (DM). However, blood glucose data and the changes in insulin induced by OGTTs contain information regarding int...
Towards a fast and efficient approach for modelling the patient-specific ventricular haemodynamics [0.03%]
一种快速高效的患者特异性心室血流动力学建模方法研究
A de Vecchi,A Gomez,K Pushparajah et al.
A de Vecchi et al.
Computer modelling of the heart has emerged over the past decade as a powerful technique to explore the cardiovascular pathophysiology and inform clinical diagnosis. The current state-of-the-art in biophysical modelling requires a wealth of...
Carl Ludwig's (1847) and Pavel Petrovich Einbrodt's (1860) physiological research and its implications for modern cardiovascular science: translator's notes relating to the English translation of two seminal papers [0.03%]
卡尔·路德维希（1847）和帕维尔·彼得罗维奇·艾恩布罗德（1860）的生理学研究及其对现代心血管科学的影响：两位开山论文英译版译者札记
Jochen Schaefer,Brigitte Lohff,Janke Jörn Dittmer
Jochen Schaefer
Respiratory interactions with the heart have remained a challenging physiological phenomenon since their discovery more than two hundred and fifty years ago. In the course of translating the seminal publications of Carl Ludwig and his disci...
Chemical specificity and conformational flexibility in proteinase-inhibitor interaction: scaffolds for promiscuous binding [0.03%]
蛋白酶-抑制剂相互作用中的化学特异性及构象柔性：多重结合的框架
Sneha Vishwanath,Narayanaswamy Srinivasan
Sneha Vishwanath
One of the most important roles of proteins in cellular milieu is recognition of other biomolecules including other proteins. Protein-protein complexes are involved in many essential cellular processes. Interfaces of protein-protein complex...
Methodology for image-based reconstruction of ventricular geometry for patient-specific modeling of cardiac electrophysiology [0.03%]
基于图像的重建心室几何形态的方法学用于患者特定的心脏电生理建模
A Prakosa,P Malamas,S Zhang et al.
A Prakosa et al.
Patient-specific modeling of ventricular electrophysiology requires an interpolated reconstruction of the 3-dimensional (3D) geometry of the patient ventricles from the low-resolution (Lo-res) clinical images. The goal of this study was to ...