Unraveling liver complexity from molecular to organ level: challenges and perspectives [0.03%]
从分子到器官水平解开肝脏的复杂性：挑战与展望
L A D&#x;Alessandro,S Hoehme,A Henney et al.
L A D&#x;Alessandro et al.
Biological responses are determined by information processing at multiple and highly interconnected scales. Within a tissue the individual cells respond to extracellular stimuli by regulating intracellular signaling pathways that in turn de...
Identifying functional gene regulatory network phenotypes underlying single cell transcriptional variability [0.03%]
识别功能性基因调控网络表型以研究单细胞转录差异
James Park,Babatunde Ogunnaike,James Schwaber et al.
James Park et al.
Recent analysis of single-cell transcriptomic data has revealed a surprising organization of the transcriptional variability pervasive across individual neurons. In response to distinct combinations of synaptic input-type, a new organizatio...
Claire A Shepherd,Andrew L Hopkins,Iva Navratilova
Claire A Shepherd
Surface plasmon resonance (SPR) is one of the primary biophysical methods for the screening of low molecular weight 'fragment' libraries, due to its low protein consumption and 'label-free' methodology. SPR biosensor interaction analysis is...
Richard J Hall,Paul N Mortenson,Christopher W Murray
Richard J Hall
Screening methods seek to sample a vast chemical space in order to identify starting points for further chemical optimisation. Fragment based drug discovery exploits the superior sampling of chemical space that can be achieved when the mole...
Virtual ablation for atrial fibrillation in personalized in-silico three-dimensional left atrial modeling: comparison with clinical catheter ablation [0.03%]
个性化三维左心房建模的房颤虚拟消融法及其与临床导管消融的比较研究
Minki Hwang,Soon-Sung Kwon,Jin Wi et al.
Minki Hwang et al.
Background: Although catheter ablation is an effective rhythm control strategy for atrial fibrillation (AF), empirically-based ablation has a substantial recurrence rate. The purposes of this study were to develop a compu...
Randomized Controlled Trial
Progress in biophysics and molecular biology. 2014 Sep;116(1):40-7. DOI:10.1016/j.pbiomolbio.2014.09.006 2014
A novel patient-specific model to compute coronary fractional flow reserve [0.03%]
一种新颖的个性化计算冠脉衍生血流储备分数的模型
Soon-Sung Kwon,Eui-Chul Chung,Jin-Seo Park et al.
Soon-Sung Kwon et al.
The fractional flow reserve (FFR) is a widely used clinical index to evaluate the functional severity of coronary stenosis. A computer simulation method based on patients' computed tomography (CT) data is a plausible non-invasive approach f...
Recent progress and prospects in Sasang constitutional medicine: a traditional type of physiome-based treatment [0.03%]
近来萨桑体质医学的进展与展望：一种基于生理模型的治疗方法
Jong Yeol Kim,Denis Noble
Jong Yeol Kim
The history of the constitution perspective in medical care dates back thousands of years and extends from the East to the West. Among the various forms of constitutional medicine, Sasang constitutional medicine (SCM) is a holistic, tailore...
Modeling of stochastic behavior of pacemaker potential in interstitial cells of Cajal [0.03%]
Cajal间质细胞起搏电位随机行为的建模研究
Jae Boum Youm,Chae Hun Leem,Sung Ryul Lee et al.
Jae Boum Youm et al.
It is widely accepted that interstitial cells of Cajal (ICCs) generate pacemaker potentials to propagate slow waves along the whole gastrointestinal tract. Previously, we constructed a biophysically based model of ICCs in mouse small intest...
Clinical application of the fibrillation number in patients with an implantable cardioverter defibrillator [0.03%]
植入型心律转复除颤器患者的纤维化数量的临床应用
Minki Hwang,Hancheol Lee,Young-Seon Lee et al.
Minki Hwang et al.
Introduction: Although ventricular tachycardia/fibrillation (VT/VF) develops suddenly with catastrophic results, its prediction is limited. We tested the fibrillation number (FibN) for potential predictor of VT/VF using c...
Controlled Clinical Trial
Progress in biophysics and molecular biology. 2014 Sep;116(1):33-9. DOI:10.1016/j.pbiomolbio.2014.09.004 2014
Computational prediction of proarrhythmogenic effect of the V241F KCNQ1 mutation in human atrium [0.03%]
计算预测V241F KCNQ1突变在人体心房中的致心律失常效应
Riski Imaniastuti,Hyun Seung Lee,Nari Kim et al.
Riski Imaniastuti et al.
Genetic factors play an important role in the pathogenesis of atrial flutter (AF). Although mutation in KCNQ1 has been widely correlated with AF, the mechanism by which mutation promotes AF remains poorly understood. The purpose of this stu...