Structural and sequential context of p53: A review of experimental and theoretical evidence [0.03%]
p53的结构和序列背景：实验与理论证据述评
Taniya Saha,Rajiv K Kar,Gaurisankar Sa
Taniya Saha
Approximately 27 million people are suffering from cancer that contains either an inactivating missense mutation of TP53 gene or partially abrogated p53 signaling pathway. Concerted action of folded and intrinsically disordered domains acco...
The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis [0.03%]
DNA依赖型蛋白激酶：参与DNA双链断裂修复和有丝分裂的多功能蛋白激酶
Nicholas Jette,Susan P Lees-Miller
Nicholas Jette
The DNA-dependent protein kinase (DNA-PK) is a serine/threonine protein kinase composed of a large catalytic subunit (DNA-PKcs) and the Ku70/80 heterodimer. Over the past two decades, significant progress has been made in elucidating the ro...
Characteristics and concepts of dynamic hub proteins in DNA processing machinery from studies of RPA [0.03%]
来自RPA的研究揭示DNA加工装置中动态核心蛋白的特征及概念
Norie Sugitani,Walter J Chazin
Norie Sugitani
DNA replication, damage response and repair require the coordinated action of multi-domain proteins operating within dynamic multi-protein machines that act upon the DNA substrate. These modular proteins contain flexible linkers of various ...
Systems approaches in integrative cardiac biology: illustrations from cardiac heterocellular signalling studies [0.03%]
系统方法在心脏整合生物学中的应用：来自心脏异细胞信号转导研究的例证
Hieu T Nim,Sarah E Boyd,Nadia A Rosenthal
Hieu T Nim
Understanding the complexity of cardiac physiology requires system-level studies of multiple cardiac cell types. Frequently, however, the end result of published research lacks the detail of the collaborative and integrative experimental de...
Has Neo-Darwinism failed clinical medicine: does systems biology have to? [0.03%]
neo-达尔文主义在临床医学上失败了吗：系统生物学就注定如此吗？
Michael J Joyner
Michael J Joyner
In this essay I argue that Neo-Darwinism ultimately led to an oversimplified genotype equals phenotype view of human disease. This view has been called into question by the unexpected results of the Human Genome Project which has painted a ...
Towards novel therapeutics for HIV through fragment-based screening and drug design [0.03%]
基于片段的筛选和药物设计在艾滋病新药研究中的应用
Theresa Tiefendbrunn,C David Stout
Theresa Tiefendbrunn
Fragment-based drug discovery has been applied with varying levels of success to a number of proteins involved in the HIV (Human Immunodeficiency Virus) life cycle. Fragment-based approaches have led to the discovery of novel binding sites ...
Chae Hun Leem,Eun Bo Shim,Denis Noble
Chae Hun Leem
Ivana Pajic-Lijakovic
Ivana Pajic-Lijakovic
Various modeling approaches have been applied to describe structural changes of the erythrocyte constituents under osmotic stress. The constituents: (1) the lipid bilayer, (2) the actin-spectrin cortex, (3) the trans-membrane protein band 3...
Jonathan Cooper,Jon Olav Vik,Dagmar Waltemath
Jonathan Cooper
Experimentation is fundamental to the scientific method, whether for exploration, description or explanation. We argue that promoting the reuse of virtual experiments (the in silico analogues of wet-lab or field experiments) would vastly im...