Uncertainty quantification of fast sodium current steady-state inactivation for multi-scale models of cardiac electrophysiology [0.03%]
心脏电生理多尺度模型中快速钠电流稳态失活的不确定性量化
Pras Pathmanathan,Matthew S Shotwell,David J Gavaghan et al.
Pras Pathmanathan et al.
Perhaps the most mature area of multi-scale systems biology is the modelling of the heart. Current models are grounded in over fifty years of research in the development of biophysically detailed models of the electrophysiology (EP) of card...
Endogenous molecular-cellular hierarchical modeling of prostate carcinogenesis uncovers robust structure [0.03%]
内源性分子-细胞层次建模发现前列腺癌生成的稳健结构
Xiaomei Zhu,Ruoshi Yuan,Leroy Hood et al.
Xiaomei Zhu et al.
We explored endogenous molecular-cellular network hypothesis for prostate cancer by constructing relevant endogenous interaction network model and analyzing its dynamical properties. Molecular regulations involved in cell proliferation, apo...
Li Fan,Kevin T DuPrez
Li Fan
XPB is a 3'-5' DNA helicase belonging to the superfamily 2 (SF2) of helicases. XPB is an essential core subunit of the eukaryotic basal transcription factor complex TFIIH which plays a dual role in transcription and DNA repair: 1) to facili...
Branching and oscillations in the epigenetic landscape of cell-fate determination [0.03%]
细胞命运决定的表观遗传景观中的分支和振荡现象
Jomar Fajardo Rabajante,Ariel Lagdameo Babierra
Jomar Fajardo Rabajante
The well-known Waddington's epigenetic landscape of cell-fate determination is not static but varies because of the dynamic gene regulation during development. However, existing mathematical models with few state variables and fixed paramet...
Molecular underpinnings of Aprataxin RNA/DNA deadenylase function and dysfunction in neurological disease [0.03%]
Aprataxin 的 RNA/DNA 去腺苷酸酶功能及其在神经疾病中的失活机制的分子机理研究
Matthew J Schellenberg,Percy P Tumbale,R Scott Williams
Matthew J Schellenberg
Eukaryotic DNA ligases seal DNA breaks in the final step of DNA replication and repair transactions via a three-step reaction mechanism that can abort if DNA ligases encounter modified DNA termini, such as the products and repair intermedia...
Can systems biology help to separate evolutionary analogies (convergent homoplasies) from homologies? [0.03%]
系统生物学能帮助人们把进化类比（趋同同像）和同源区别开来吗？
Malcolm S Gordon,Julia C Notar
Malcolm S Gordon
Convergent evolutionary analogies (homoplasies) of many kinds occur in diverse phylogenetic clades/lineages on both the animal and plant branches of the Tree of Life. Living organisms whose last common ancestors lived millions to hundreds o...
Rossana Occhipinti,Walter F Boron
Rossana Occhipinti
pH is one of the most important parameters in life, influencing virtually every biological process at the cellular, tissue, and whole-body level. Thus, for cells, it is critical to regulate intracellular pH (pHi) and, for multicellular orga...
T C Hodgman,I Ajmera
T C Hodgman
Plant biology has had longstanding successes from applying mathematical models to plant systems. Of the >160 models that have been developed to date, a closer study is made of crop models and more recent plant models. The latter focus on ho...
Piero R Bianco
Piero R Bianco
RecG is a potent, atypical, monomeric DNA helicase. It simultaneously couples ATP hydrolysis to duplex unwinding and rewinding, and to the displacement of proteins bound to the DNA. A model is presented for the localization of the enzyme to...
Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair [0.03%]
构想Mre11-Rad50-Nbs1复合物的动态及灵活性以诠释其在DNA复制和修复中的作用
Julien Lafrance-Vanasse,Gareth J Williams,John A Tainer
Julien Lafrance-Vanasse
The Mre11-Rad50-Nbs1 (MRN) complex is a dynamic macromolecular machine that acts in the first steps of DNA double strand break repair, and each of its components has intrinsic dynamics and flexibility properties that are directly linked wit...