Krishnendu Mukherjee,Richard M Twyman,Andreas Vilcinskas
Krishnendu Mukherjee
Epigenetic inheritance refers to changes in gene expression that are heritable across generations but are not caused by changes in the DNA sequence. Many environmental factors are now known to cause epigenetic changes, including the presenc...
Epigenetic inheritance and evolution: A paternal perspective on dietary influences [0.03%]
表观遗传学的继承和演变：关于饮食影响的父系视角
Adelheid Soubry
Adelheid Soubry
The earliest indications for paternally induced transgenerational effects from the environment to future generations were based on a small number of long-term epidemiological studies and some empirical observations. Only recently have exper...
Strategies to interfere with PDZ-mediated interactions in neurons: What we can learn from the rabies virus [0.03%]
来自狂犬病毒的启示：干扰神经元中PDZ介导相互作用的策略
Célia Caillet-Saguy,Pierre Maisonneuve,Florent Delhommel et al.
Célia Caillet-Saguy et al.
PDZ (PSD-95/Dlg/ZO-1) domains play a major role in neuronal homeostasis in which they act as scaffold domains regulating cellular trafficking, self-association and catalytic activity of essential proteins such as kinases and phosphatases. B...
In silico design of low molecular weight protein-protein interaction inhibitors: Overall concept and recent advances [0.03%]
基于计算的低分子量蛋白质-蛋白质相互作用抑制剂的设计：总体概念及最新进展
Mélaine A Kuenemann,Olivier Sperandio,Céline M Labbé et al.
Mélaine A Kuenemann et al.
Protein-protein interactions (PPIs) are carrying out diverse functions in living systems and are playing a major role in the health and disease states. Low molecular weight (LMW) "drug-like" inhibitors of PPIs would be very valuable not onl...
Bashar Ibrahim
Bashar Ibrahim
Reproduction and natural selection are the key elements of life. In order to reproduce, the genetic material must be doubled, separated and placed into two new daughter cells, each containing a complete set of chromosomes and organelles. In...
Diverse binding modes, same goal: The receptor recognition mechanism of botulinum neurotoxin [0.03%]
多种结合模式，相同目标：肉毒神经毒素的受体识别机制
Kwok-Ho Lam,Guorui Yao,Rongsheng Jin
Kwok-Ho Lam
Botulinum neurotoxins (BoNTs) are among the most deadly toxins known. They act rapidly in a highly specific manner to block neurotransmitter release by cleaving the soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNAR...
Phosphopeptide interactions with BRCA1 BRCT domains: More than just a motif [0.03%]
BRCA1 BRCT 结构域与磷酸肽的相互作用：不仅仅是保守基序的问题
Qian Wu,Harry Jubb,Tom L Blundell
Qian Wu
BRCA1 BRCT domains function as phosphoprotein-binding modules for recognition of the phosphorylated protein-sequence motif pSXXF. While the motif interaction interface provides strong anchor points for binding, protein regions outside the m...
Insights from a decade of biophysical studies on MutL: Roles in strand discrimination and mismatch removal [0.03%]
十年来MutL生物物理研究的见解：在链区分和错配移除中的作用
Alba Guarné,Jean-Baptiste Charbonnier
Alba Guarné
DNA mismatch repair (MMR) is a conserved pathway that safeguards genome integrity by correcting replication errors. The coordinated actions of two proteins (MutS and MutL) initiate the mismatch repair response and defects in the genes encod...
Sukhendu B Dev
Sukhendu B Dev
Many outstanding problems have been solved in biology and medicine for which scientists have been awarded prestigious prizes including the Nobel Prize, Lasker Award and Breakthrough Prizes in life sciences. These have been the fruits of yea...
Flexibility and small pockets at protein-protein interfaces: New insights into druggability [0.03%]
蛋白质-蛋白质相互作用界面的灵活性和小口袋：可药物性新见解
Harry Jubb,Tom L Blundell,David B Ascher
Harry Jubb
The transient assembly of multiprotein complexes mediates many aspects of cell regulation and signalling in living organisms. Modulation of the formation of these complexes through targeting protein-protein interfaces can offer greater sele...