Consequences of dietary methyl donor supplements: Is more always better? [0.03%]
饮食甲基供体补充剂的影响：更多总是更好吗？
Kimberly R Shorter,Michael R Felder,Paul B Vrana
Kimberly R Shorter
Epigenetic mechanisms are now recognized to play roles in disease etiology. Several diseases increasing in frequency are associated with altered DNA methylation. DNA methylation is accomplished through metabolism of methyl donors such as fo...
Multigenerational and transgenerational inheritance of drug exposure: The effects of alcohol, opiates, cocaine, marijuana, and nicotine [0.03%]
药物暴露的多代和跨代遗传：酒精、阿片类、可卡因、大麻和尼古丁的影响
Nicole L Yohn,Marisa S Bartolomei,Julie A Blendy
Nicole L Yohn
Familial inheritance of drug abuse is composed of both genetic and environmental factors. Additionally, epigenetic transgenerational inheritance may provide a means by which parental drug use can influence several generations of offspring. ...
Heath G Pascoe,Yuxiao Wang,Xuewu Zhang
Heath G Pascoe
Signaling through plexin, the major cell surface receptor for semaphorin, plays critical roles in regulating processes such as neuronal axon guidance, angiogenesis and immune response. Plexin is normally kept inactive in the absence of sema...
Structural basis for incision at deaminated adenines in DNA and RNA by endonuclease V [0.03%]
脱氨腺嘌呤内切酶V切割DNA和RNA的结构基础
Bjørn Dalhus,Ingrun Alseth,Magnar Bjørås
Bjørn Dalhus
Deamination of the exocyclic amines in adenine, guanine and cytosine forms base lesions that may lead to mutations if not removed by DNA repair proteins. Prokaryotic endonuclease V (EndoV/Nfi) has long been known to incise DNA 3' to a varie...
The role of TRPV1 in improving VSMC function and attenuating hypertension [0.03%]
TRPV1改善血管平滑肌细胞功能及降压作用的研究进展
Ming-Jie Zhang,Yan-Wei Yin,Bing-Hu Li et al.
Ming-Jie Zhang et al.
The transient receptor potential vanilloid type 1 (TRPV1) channel, a ligand-gated cation channel of the TRP subfamily, can be activated by multiple stimuli, including capsaicin. Currently, cumulative studies have demonstrated an interesting...
Progress in studying intrinsically disordered proteins with atomistic simulations [0.03%]
利用原子模拟研究固有无序蛋白的进展
Nathaniel Stanley,Santiago Esteban-Martín,Gianni De Fabritiis
Nathaniel Stanley
Intrinsically disordered proteins are increasingly the focus of biological research since their significance was acknowledged over a decade ago. Due to their importance in biomolecular interactions, they are found to play key roles in many ...
Maternal diabetes, gestational diabetes and the role of epigenetics in their long term effects on offspring [0.03%]
母体糖尿病和妊娠期糖尿病对后代远期影响的表观遗传机制研究
Ronald C W Ma,Greg E Tutino,Karen A Lillycrop et al.
Ronald C W Ma et al.
There is a global epidemic of obesity and diabetes, and current efforts to curb the diabetes epidemic have had limited success. Epidemiological studies have highlighted increased risk of obesity, diabetes and cardiovascular complications in...
Elusive inheritance: Transgenerational effects and epigenetic inheritance in human environmental disease [0.03%]
难以捉摸的遗产：人类环境疾病的跨世代影响及表观遗传学传承
Suzanne N Martos,Wan-Yee Tang,Zhibin Wang
Suzanne N Martos
Epigenetic mechanisms involving DNA methylation, histone modification, histone variants and nucleosome positioning, and noncoding RNAs regulate cell-, tissue-, and developmental stage-specific gene expression by influencing chromatin struct...
Lilla Ozgyin,Edina Erdős,Dóra Bojcsuk et al.
Lilla Ozgyin et al.
Nuclear Receptors are ligand-activated transcription factors that translate information about the lipid environment into specific genetic programs, a property that renders them good candidates to be mediators of rapid adaptation changes of ...
Adriano Henney,Peter Hunter,Andrew McCulloch et al.
Adriano Henney et al.