Kimberly R Shorter,Brooke H Miller
Kimberly R Shorter
Epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNAs, have been implicated in a number of complex diseases. Schizophrenia and other major psychiatric and neurodevelopmental disorders are associated...
Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors [0.03%]
在细胞调节系统中实现高信噪比：FGFR和MET受体多蛋白跨膜组装的空间组织结构
Michal Blaszczyk,Nicholas J Harmer,Dimitri Y Chirgadze et al.
Michal Blaszczyk et al.
How is information communicated both within and between cells of living systems with high signal to noise? We discuss transmembrane signaling models involving two receptor tyrosine kinases: the fibroblast growth factor receptor (FGFR) and t...
Wei Wu,Chengsong Yan,Xiaoshan Shi et al.
Wei Wu et al.
T-cell receptor (TCR) is a key receptor in the immune system that can recognize antigen and initiate adaptive immune response. TCR activity needs to be regulated in a precise manner to trigger sufficient response to foreign pathogens but av...
ZNRF3/RNF43--A direct linkage of extracellular recognition and E3 ligase activity to modulate cell surface signalling [0.03%]
ZNRF3/RNF43——介导细胞表面信号通路的外源识别和E3泛素连接酶活性的直接联系
Matthias Zebisch,E Yvonne Jones
Matthias Zebisch
The interactions of extracellular ligands with single membrane spanning receptors, such as kinases, typically serve to agonise or antagonise the intracellular activation of signalling pathways. Within the cell, E3 ligases can act to alter t...
Yong Hwee Foo,Yunfeng Gao,Hongfang Zhang et al.
Yong Hwee Foo et al.
Two-component regulatory systems drive signal transduction in bacteria. The simplest of these employs a membrane sensor kinase and a cytoplasmic response regulator. Environmental sensing is typically coupled to gene regulation. The histidin...
John A Tainer
John A Tainer
Determining the geometry of oligomers of the human epidermal growth factor family on cells with 7 nm resolution [0.03%]
确定人表皮生长因子家族寡聚体在细胞上的几何结构（7纳米分辨率）
Laura C Zanetti-Domingues,Michael Hirsch,Christopher J Tynan et al.
Laura C Zanetti-Domingues et al.
Dimerisation, oligomerisation, and clustering of receptor molecules are important for control of the signalling process. There has been a lack of suitable methods for the study and quantification of these processes in cells. Here we describ...
Signaling mechanism of the netrin-1 receptor DCC in axon guidance [0.03%]
Netrin-1受体DCC在轴突导向中的信号转导机制
L Finci,Y Zhang,R Meijers et al.
L Finci et al.
DCC (Deleted in Colorectal Cancer) is a single-pass transmembrane protein that belongs to the immunoglobulin superfamily. It was originally identified as a prognostic tumor marker and then subsequently found to be a receptor for netrin-1. D...
Analysis on the effect of the distances and inclination angles between human head and mobile phone on SAR [0.03%]
人头部与手机间距及倾斜角度对SAR影响分析
M I Hossain,M R I Faruque,M T Islam
M I Hossain
The aim of this paper is to investigate the effects of the distances between the human head and internal cellular device antenna on the specific absorption rate (SAR). This paper also analyzes the effects of inclination angles between user ...
Phosphorylation of epigenetic "readers, writers and erasers": Implications for developmental reprogramming and the epigenetic basis for health and disease [0.03%]
表观遗传“阅读器、书写器和擦除器”的磷酸化：对发育再编程及表观遗传健康与疾病的潜在影响
Lindsey S Treviño,Quan Wang,Cheryl L Walker
Lindsey S Treviño
Epigenetic reprogramming that occurs during critical periods of development can increase the susceptibility to many diseases in adulthood. Programming of the epigenome during development occurs via the activity of a variety of epigenetic mo...