From creativity to perception: The conditions of possibility for a true biology [0.03%]
从创新到认知：真正的生物学之可能条件
Roland Cazalis
Roland Cazalis
The phenomenologist Renaud Barbaras defends an alternative conception of life against the well-known proposals that view life as self-preserving or seeking to replicate its own means of replication in the form of repetition instead of creat...
Targeting protein-protein interactions (PPIs) of transcription factors: Challenges of intrinsically disordered proteins (IDPs) and regions (IDRs) [0.03%]
转录因子的蛋白质-蛋白质相互作用(PPIs)靶向：内在无序蛋白(IDPs)和内在无序区(IDRs)面临的挑战
Susan Sammak,Giovanna Zinzalla
Susan Sammak
In this review we discuss recent progress in targeting the protein-protein interactions made by oncogenic transcription factors. We particularly focus on the challenges posed by the prevalence of intrinsically disordered regions in this cla...
A current perspective on the compensatory effects of urea and methylamine on protein stability and function [0.03%]
尿素和甲胺对蛋白质稳定性和功能的补偿效应的最新研究进展
Safikur Rahman,Marina Warepam,Laishram R Singh et al.
Safikur Rahman et al.
Urea is a strong denaturant and inhibits many enzymes but is accumulated intracellularly at very high concentrations (up to 3-4 M) in mammalian kidney and in many marine fishes. It is known that the harmful effects of urea on the macromolec...
Stabilization of Protein-Protein Interactions in chemical biology and drug discovery [0.03%]
化学生物和药物发现中蛋白质-蛋白质相互作用的稳定化
David Bier,Philipp Thiel,Jeroen Briels et al.
David Bier et al.
More than 300,000 Protein-Protein Interactions (PPIs) can be found in human cells. This number is significantly larger than the number of single proteins, which are the classical targets for pharmacological intervention. Hence, specific and...
How to awaken your nanomachines: Site-specific activation of focal adhesion kinases through ligand interactions [0.03%]
如何激活你的纳米机器：通过配体相互作用在特定位置激活粘着斑激酶
Katarzyna W Walkiewicz,Jean-Antoine Girault,Stefan T Arold
Katarzyna W Walkiewicz
The focal adhesion kinase (FAK) and the related protein-tyrosine kinase 2-beta (Pyk2) are highly versatile multidomain scaffolds central to cell adhesion, migration, and survival. Due to their key role in cancer metastasis, understanding an...
Andrew J Wilson
Andrew J Wilson
The development of protein-protein interaction (PPIs) inhibitors represents a challenging goal in chemical biology and drug discovery. PPIs are problematic targets because they involve large surfaces with less well defined features and reco...
The master switchers in the aging of cardiovascular system, reverse senescence by microRNA signatures; as highly conserved molecules [0.03%]
心血管系统衰老的主调控开关，通过作为高度保守分子的微RNA特征逆转衰老
Fatemeh Pourrajab,Abbas Vakili Zarch,Seyedhossein Hekmatimoghaddam et al.
Fatemeh Pourrajab et al.
The incidence of CVD increases with aging, because of long-term exposure to risk factors/stressors. Aging is a complex biological process resulting in progressive loss of physiological integrity, leading to impaired function and increased v...
Protein-protein interactions within the ensemble, eukaryotic V-ATPase, and its concerted interactions with cellular machineries [0.03%]
真核V-ATP酶系统内的蛋白质-蛋白质相互作用及其与细胞机器的协同相互作用
Asha Manikkoth Balakrishna,Malathy Sony Subramanian Manimekalai,Gerhard Grüber
Asha Manikkoth Balakrishna
The V1VO-ATPase (V-ATPase) is the important proton-pump in eukaryotic cells, responsible for pH-homeostasis, pH-sensing and amino acid sensing, and therefore essential for cell growths and metabolism. ATP-cleavage in the catalytic A3B3-hexa...
How B cells remember? A sophisticated cytoplasmic tail of mIgG is pivotal for the enhanced transmembrane signaling of IgG-switched memory B cells [0.03%]
B细胞如何记住？mIgG的复杂胞质尾对IgG转换的记忆B细胞中增强的跨膜信号转导至关重要
Xiangjun Chen,Gen Li,Zhengpeng Wan et al.
Xiangjun Chen et al.
Antibody memory is critical for protection against many human infectious diseases and is the basis for nearly all current human vaccines. Isotype switched immunoglobulin (Ig) G-expressing memory B cells are considered as one of the fundamen...
Probing the dynamics of growth factor receptor by single-molecule fluorescence imaging [0.03%]
通过单分子荧光成像探测生长因子受体的动力学特性
Yahong Sun,Nan Li,Xiaohong Fang
Yahong Sun
Single-molecule fluorescence imaging with living cells offers a new approach to visualize and monitor individual proteins during their cellular activities. It facilities the study of cell signaling proteins whose structures and interactions...