The accuracy of biochemical interactions is ensured by endothermic stepwise kinetics [0.03%]
内能分步动力学确保生化交互的准确性
Denis Michel,Benjamin Boutin,Philippe Ruelle
Denis Michel
The discerning behavior of living systems relies on accurate interactions selected from the lot of molecular collisions occurring in the cell. To ensure the reliability of interactions, binding partners are classically envisioned as finely ...
Early afterdepolarizations promote transmural reentry in ischemic human ventricles with reduced repolarization reserve [0.03%]
缺血性心室复极储备下降时早期后除极促进壁内折返形成
Sara Dutta,Ana Mincholé,Ernesto Zacur et al.
Sara Dutta et al.
Aims: Acute ischemia is a major cause of sudden arrhythmic death, further promoted by potassium current blockers. Macro-reentry around the ischemic region and early afterdepolarizations (EADs) caused by electrotonic curre...
Yuan Liu,Xiao-Li Zhang,Li Chen et al.
Yuan Liu et al.
Bone regeneration is a promising avenue for osteoporosis (OP) treatment. It consists of several procedures, such as the osteogenic differentiation of mesenchymal stem cells as well as the proliferation and maturation of osteoblasts. Many ep...
Dispersion in ventricular repolarization in the human, canine and porcine heart [0.03%]
人、犬和猪心室复极的离散化
Tobias Opthof,Michiel J Janse,Veronique M F Meijborg et al.
Tobias Opthof et al.
Dispersion in repolarization is important for the genesis of the T wave, and for the induction of reentrant arrhtyhmias. Because the T wave differs across species our intent here is to review the epicardial, endocardial and transmural repol...
The nervous heart [0.03%]
患愁的心fgets(stdin);fgets(stdin);fgets(stdin);fgets(stdin);fgets(stdin);fgets(stdin);fgets(stdin);fgets(stdin);fgets(stdin);fgets(stdin);fgets(stdin);fgets(stdin);fgets(stdin);fgets(stdin);fgets(stdin);fgets(stdin);fgets(stdin);fgets(stdin);fgets(stdin);
Crystal M Ripplinger,Sami F Noujaim,Dominik Linz
Crystal M Ripplinger
Many cardiac electrophysiological abnormalities are accompanied by autonomic nervous system dysfunction. Here, we review mechanisms by which the cardiac nervous system controls normal and abnormal excitability and may contribute to atrial a...
Cell viability modulation through changes of Ca(2+)-dependent signalling pathways [0.03%]
通过改变钙离子依赖性信号通路调节细胞活力
Karolina Wójcik-Piotrowicz,Jolanta Kaszuba-Zwoińska,Eugeniusz Rokita et al.
Karolina Wójcik-Piotrowicz et al.
The aim of the study was to determine the correlations between intracellular calcium ion level and a cell's ability to survive. The intracellular concentration of Ca(2+) ions, maintained through different mechanisms, plays an important role...
T Alexander Quinn,Crystal M Ripplinger
T Alexander Quinn
The protective effect of ursodeoxycholic acid in an in vitro model of the human fetal heart occurs via targeting cardiac fibroblasts [0.03%]
熊去氧胆酸在体外人类胎儿心脏保护模型中通过靶向心肌纤维细胞发挥作用
Francisca Schultz,Alveera Hasan,Anita Alvarez-Laviada et al.
Francisca Schultz et al.
Bile acids are elevated in the blood of women with intrahepatic cholestasis of pregnancy (ICP) and this may lead to fetal arrhythmia, fetal hypoxia and potentially fetal death in utero. The bile acid taurocholic acid (TC) causes abnormal ca...
Calcium/calmodulin-dependent protein kinase IV: A multifunctional enzyme and potential therapeutic target [0.03%]
钙/钙调素依赖性蛋白激酶IV：多功能的酶及潜在的治疗靶点
Huma Naz,Asimul Islam,Faizan Ahmad et al.
Huma Naz et al.
The calcium/calmodulin-dependent protein kinase IV (CAMKIV) belongs to the serine/threonine protein kinase family, and is primarily involved in transcriptional regulation in lymphocytes, neurons and male germ cells. CAMKIV operates the sign...
The Popeye domain containing protein family--A novel class of cAMP effectors with important functions in multiple tissues [0.03%]
新颖的cAMP效应物波佩蛋白家族在多个组织中发挥重要作用
Roland F R Schindler,Thomas Brand
Roland F R Schindler
Popeye domain containing (Popdc) proteins are a unique family, which combine several different properties and functions in a surprisingly complex fashion. They are expressed in multiple tissues and cell types, present in several subcellular...