Recent Advances in Targeting Regions of Interest for In Situ Cryo-Electron Tomography of Cellular Architecture [0.03%]
用于细胞结构就地 cryo-电子层析成像的定位兴趣区域的最新进展
Christopher Eugenio Williem,Viranitasya Stephanie Himawan,Maykel T E Manawan et al.
Christopher Eugenio Williem et al.
Cryogenic electron tomography (cryo-ET) enables in situ structural analysis of macromolecular assemblies within their native cellular environments, spanning more than four orders of magnitude in spatial scale, from micrometre-level cellular...
Kevser Kübra Kırboğa,Ecir Uğur Küçüksille
Kevser Kübra Kırboğa
Energy models play a crucial role in the advancement of computational de novo protein engineering, enabling the design of novel proteins with tailored functionalities. Proteins serve as the foundation of biochemical processes, making their ...
Modulating bone remodeling through magnetic field: approach targeting metabolic dysregulation in diabetic osteoporosis [0.03%]
磁场调节骨重建：靶向糖尿病性骨质疏松代谢紊乱的治疗策略
Chunqin Li,Xige Dong,Mengxu Sun et al.
Chunqin Li et al.
Diabetes mellitus, a chronic metabolic disorder associated with high risk of cardiovascular disease, kidney disease, neuropathy and bone disorder, has emerged as a globally epidemic public health issue. Osteoporosis, the most common bone di...
Impact of Hypoxia-inducible factor 1 in the oncogenic progression of Kaposi's sarcoma-associated herpes virus [0.03%]
缺氧诱导因子HIF-1在卡波西肉瘤疱疹病毒致癌过程中的作用
Koushik Chakraborty,Monalisha Ghosh,Dristi Majumdar et al.
Koushik Chakraborty et al.
The development of modern molecular biology helps us to identify the link between Kaposi's sarcoma-associated herpesvirus (KSHV) and multiple human malignancies by infecting B-lymphocyte or endothelial cells. Infection with KSHV plays a cru...
Unraveling cerebral ultrastructural alterations in TLR4-mediated neuroinflammation via transmission electron microscopy: a systematic preclinical review [0.03%]
通过透射电子显微镜解构 toll 样受体 4 介导的神经炎症相关的脑室壁结构变化：系统性临床前研究综述
Eulália Rebeca Silva-Araújo,Raul Manhães-de-Castro,Ana Elisa Toscano et al.
Eulália Rebeca Silva-Araújo et al.
Ultrastructural alterations in the central nervous system-such as synaptic dysfunction, axonal injury, and demyelination-contribute to the cognitive and sensorimotor deficits observed in neurological damage, in which TLR4-mediated neuroinfl...
Progress in constitutive modeling of arterial wall tissue mechanics: from theoretical frameworks to clinical application [0.03%]
动脉壁组织力学的本构模型研究进展：从中观理论框架到临床应用
Qian Fan,Dezhong Qi,Qiang Xiao et al.
Qian Fan et al.
Cardiovascular disease (CVD) is a leading cause of mortality worldwide, and the mechanical behavior of arterial wall tissue (AWT) is central to its initiation and progression. This review surveys advances in constitutive models of AWT over ...
Field potential duration and its variability as essential parameters for revealing proarrhythmia: problematic aspects of analysis in cardiomyocytes derived from human pluripotent stem cells [0.03%]
心室易发生异常参数的重要参数：源自人类多能干细胞的心肌细胞分析中存在的问题方面
Martin Král,Olga Švecová,Pavel Jurák et al.
Martin Král et al.
The microelectrode array (MEA) is an easy, high-throughput method, ideal for obtaining a large amount of data from excitable cells, including cardiomyocytes. However, the analysis can be problematic, especially the analysis of the field pot...
Eugenio Frixione,Lourdes Ruiz-Zamarripa
Eugenio Frixione
Water, elected as Molecule of the Year 2024 by the American Society for Biochemistry and Molecular Biology, is the substance in which life originated on this planet and became then involved in numerous cell functions of all animal and veget...
Amirhamzeh Farajollahi
Amirhamzeh Farajollahi
The past decade has seen growing interest in injectable hydrogels for cancer therapy due to their tunable polymer backbones and high chemical versatility. Researchers are engineering injectable hydrogel platforms for chemotherapy, immunothe...
Quantum mechanics as a tool to decipher the mutational landscape of human disease [0.03%]
量子力学作为解读人类疾病突变图谱的工具
Eustathia-Irene Zavitsanou,Argyris Dallis,Athanasios Balaskas et al.
Eustathia-Irene Zavitsanou et al.
Quantum mechanics (QM) is emerging as a powerful framework for studying disease-related mutations at the atomic and subatomic levels, providing mechanistic insights beyond those of classical models. In this review, we examined primary resea...