Ben Cools,Michaela B Smith,Pierre Boutouyrie et al.
Ben Cools et al.
Spaceflight exposes humans to a unique environment characterized by altered gravity, cosmic radiation and psychological stress, resulting in extensive physiological adaptations across multiple organ systems. This review provides a state-of-...
Mechanical signature of cancer cells: From cytoskeletal alterations to cell rheology [0.03%]
癌细胞的机械特征：从细胞骨架变化到细胞流变学
Ibrahim Ghoytasi,Mahsa Salehi,Alireza Fotouhi et al.
Ibrahim Ghoytasi et al.
The continued rise in cancer-related deaths suggests that the precise nature of the disease remains poorly understood. In the field of cellular mechanics, researchers have identified mechanobiological aspects of cancer cells by examining th...
The Regulated Cell Death Nexus: From Molecular Mechanisms to NINJ1-Mediated Membrane Rupture [0.03%]
受调控细胞死亡通路：从分子机制到NINJ1介导的膜破裂
Ye Tao,Tianming Qiu,Jingyuan Zhang et al.
Ye Tao et al.
Regulated cell death (RCD) is a fundamental, genetically programmed process essential for maintaining intracellular homeostasis and orchestrating physiological functions. Mounting evidence has established that distinct RCD pathways-includin...
Reframing Antibacterial Strategies Through Physical Targeting: Mechanisms and Future Directions [0.03%]
通过物理靶向重构抗菌策略：机制与未来方向
Mohammad Varzandeh,Mohammad Ehsan Ehsani Nasab,Minoo Karbasi et al.
Mohammad Varzandeh et al.
Development of novel antibacterial techniques and targeting is essential due to increased antibiotic resistance of bacteria. Nano- and microparticles (MPs) provided a viable platform that addresses the limitations of conventional antibacter...
Voltage-gated sodium channels in pain: Which channels, which blockers, and where NaV1.7 fits [0.03%]
电压门控钠通道与疼痛：哪些通道，哪些阻断剂以及NaV1.7的位置在哪？
J A Sutemieva,D V Sobenin
J A Sutemieva
Chronic pain remains difficult to treat because the clinical utility of many analgesics is limited by dose-limiting adverse effects, tolerance, and addiction liability. Voltage-gated sodium channels (NaV), which govern the initiation and pr...
Classical and modern differential scanning calorimetry of proteins: Integrating equilibrium thermodynamics with emerging diagnostic and pharmaceutical applications [0.03%]
经典和现代差示扫描量热法在蛋白质中的应用：平衡热力学与新兴诊断和制药应用的结合
Mousa Bohlooli,Ali Akbar Saboury,Mansour Ghaffari-Moghaddam et al.
Mousa Bohlooli et al.
Differential scanning calorimetry (DSC) remains a cornerstone technique for quantifying protein stability, unfolding cooperativity, and thermodynamic reversibility. While the classical calorimetric framework-rooted in excess heat-capacity a...
Molecular mechanisms of α4β7 engagement by HIV-1 and implications for vaccine design [0.03%]
HIV-1与α4β7结合的分子机制及其对疫苗设计的意义
Mahmoud M Yaseen,Nizar M Abuharfeil,Homa Darmani
Mahmoud M Yaseen
HIV-1 transmission is initiated at mucosal surfaces, where the virus engages the gut-homing integrin α4β7 to enhance infectivity and promote early pathogenesis. This review synthesizes molecular, structural, and immunological evidence to ...
Serum albumin-ligand interactions: Experimental and computational approaches [0.03%]
血清白蛋白-配体相互作用的实验和计算方法研究
Nicoleta Cazacu,Claudia G Chilom
Nicoleta Cazacu
Biomolecular interactions, naturally occurring in living organisms, mediate most of the cellular functions, contribute to understanding the nature, function, and behavior of macromolecules, like proteins, and help to predict the biological ...
NRF2-KEAP1 as a Redox Signal-Resolution Circuit: Beyond the Antioxidant Switch [0.03%]
NRF2-KEAP1作为氧化还原信号解析回路：抗氧化开关的作用之外
Ardie Barry Sailis
Ardie Barry Sailis
The NRF2-KEAP1 pathway is classically described as an inducible antioxidant switch, yet this binary framework fails to explain why transient NRF2 activation is broadly cytoprotective whereas sustained activation drives pathology across canc...
Massimiliano Zaniboni
Massimiliano Zaniboni
The electrical activity of the atrial chambers of the heart is currently investigated by means of the most advanced techniques like electrocardiographic imaging and three-dimensional numerical modeling. Studies on the electrotonic interacti...