Bioelectric pharmacology of cancer: A systematic review of ion channel drugs affecting the cancer phenotype [0.03%]
癌症生物电药理学：影响癌症表型的离子通道药物系统评价
Karina Kofman,Michael Levin
Karina Kofman
Cancer is a pernicious and pressing medical problem; moreover, it is a failure of multicellular morphogenesis that sheds much light on evolutionary developmental biology. Numerous classes of pharmacological agents have been considered as ca...
Exploring the regulatory role of tsRNAs in the TNF signaling pathway: Implications for cancer and non-cancer diseases [0.03%]
tsRNA在TNF信号通路中的调控作用探索：对癌症和非癌症疾病的意义研究
Qurui Wang,Qinyuan Huang,Xiaowei Ying et al.
Qurui Wang et al.
Transfer RNA-derived small RNAs (tsRNAs), a recently identified subclass of small non-coding RNAs (sncRNAs), emerge through the cleavage of mature transfer RNA (tRNA) or tRNA precursors mediated by specific enzymes. The tumor necrosis facto...
Armando Aranda-Anzaldo,Myrna A R Dent,Edith Segura-Anaya et al.
Armando Aranda-Anzaldo et al.
Proteins are acknowledged as the phenotypical manifestation of the genotype, because protein-coding genes carry the information for the strings of amino acids that constitute the proteins. It is widely accepted that protein function depends...
In vitro study of the expression of autophagy genes ATG101, mTOR and AMPK in breast cancer with treatment of lactoferrin and in silico study of their communication networks and protein interactions [0.03%]
体外乳铁蛋白治疗乳腺癌自噬基因ATG101、mTOR和AMPK表达的实验研究及它们通讯网络与蛋白质相互作用的计算模拟研究
Atefeh Mashhadi Kholerdi,Fatemeh Moradian,Havva Mehralitabar
Atefeh Mashhadi Kholerdi
Autophagy is a new window of science that has been noticed due to the importance of specific therapies in cancer. In this study, the effect of lactoferrin (Lf) on the expression level of ATG101, mTOR and AMPK genes in breast cancer cell lin...
Hooshang Nikjoo,Shirin Rahmanian,Reza Taleei
Hooshang Nikjoo
The paper presents a review of mechanistic modelling studies of DNA damage and DNA repair, and consequences to follow in mammalian cell nucleus. We hypothesize DNA deletions are consequences of repair of double strand breaks leading to the ...
William B Miller Jr,František Baluška,Arthur S Reber et al.
William B Miller Jr et al.
Natural selection has a formal definition as the natural process that results in the survival and reproductive success of individuals or groups best adjusted to their environment, leading to the perpetuation of those genetic qualities best ...
Exploring gene regulation and biological processes in insects: Insights from omics data using gene regulatory network models [0.03%]
利用基因调控网络模型探讨昆虫的基因调控及生物过程：组学数据带来的启示
Fong Ting Chee,Sarahani Harun,Kauthar Mohd Daud et al.
Fong Ting Chee et al.
Gene regulatory network (GRN) comprises complicated yet intertwined gene-regulator relationships. Understanding the GRN dynamics will unravel the complexity behind the observed gene expressions. Insect gene regulation is often complicated d...
Cooperative genes in smart systems: Toward an inclusive new synthesis in evolution [0.03%]
智慧系统中的合作基因：通向进化新综合论的包容之路
Peter A Corning
Peter A Corning
For more than half a century, biologist Julian Huxley's term, the "Modern Synthesis", has been used as a label for a model of biological evolution where genetic influences are viewed as a principal source of creativity and change. Over the ...
Zhi Xiong Chong,Wan Yong Ho,Swee Keong Yeap
Zhi Xiong Chong
Dysregulation of long non-coding RNA (lncRNA) HOXA-AS3 has been shown to contribute to the development of multiple cancer types. Several studies have presented the tumour-modulatory role or prognostic significance of this lncRNA in various ...
A hypothesis of teleological evolution, via endogenous acetylcholine, nitric oxide, and calmodulin pathways [0.03%]
一种假说：通过内源性乙酰胆碱、一氧化氮和钙调素通路的目的论进化
Amelia Lewis
Amelia Lewis
The Extended Evolutionary Synthesis (EES) addresses the issues in evolutionary biology which cannot be explained by neo-Darwinian theory. The EES paradigm recognises teleology and agency in living systems, and identifies that organisms can ...