An automated system using spatial oversampling for optical mapping in murine atria. Development and validation with monophasic and transmembrane action potentials [0.03%]
一种用于小鼠心房光学映射的自动空间过取样系统。开发与单向和跨膜动作电位验证
Ting Yue Yu,Fahima Syeda,Andrew P Holmes et al.
Ting Yue Yu et al.
We developed and validated a new optical mapping system for quantification of electrical activation and repolarisation in murine atria. The system makes use of a novel 2nd generation complementary metal-oxide-semiconductor (CMOS) camera wit...
Living cardiac tissue slices: an organotypic pseudo two-dimensional model for cardiac biophysics research [0.03%]
体外心脏组织片：一种心脏生物物理学研究的器官型伪二维模型
Ken Wang,Derek Terrar,David J Gavaghan et al.
Ken Wang et al.
Living cardiac tissue slices, a pseudo two-dimensional (2D) preparation, have received less attention than isolated single cells, cell cultures, or Langendorff-perfused hearts in cardiac biophysics research. This is, in part, due to difficu...
Advantages of crystallographic fragment screening: functional and mechanistic insights from a powerful platform for efficient drug discovery [0.03%]
基于晶体学片段筛选的优势：一个高效药物发现平台的功能和机制见解
Disha Patel,Joseph D Bauman,Eddy Arnold
Disha Patel
X-ray crystallography has been an under-appreciated screening tool for fragment-based drug discovery due to the perception of low throughput and technical difficulty. Investigators in industry and academia have overcome these challenges by ...
Interrogation of living myocardium in multiple static deformation states with diffusion tensor and diffusion spectrum imaging [0.03%]
应用弥散张量及弥散频谱成像技术研究心肌在多种静态形变状态下的生理功能
Maelene Lohezic,Irvin Teh,Christian Bollensdorff et al.
Maelene Lohezic et al.
Diffusion tensor magnetic resonance imaging (MRI) reveals valuable insights into tissue histo-anatomy and microstructure, and has steadily gained traction in the cardiac community. Its wider use in small animal cardiac imaging in vivo has b...
Pablo Lamata,Ramón Casero,Valentina Carapella et al.
Pablo Lamata et al.
Computational models have become a fundamental tool in cardiac research. Models are evolving to cover multiple scales and physical mechanisms. They are moving towards mechanistic descriptions of personalised structure and function, includin...
Patient-specific modeling of ventricular activation pattern using surface ECG-derived vectorcardiogram in bundle branch block [0.03%]
基于束支传导阻滞的体表心电导联向量心电图的患者特异性建模心室激活模式
Christopher T Villongco,David E Krummen,Paul Stark et al.
Christopher T Villongco et al.
Patient-specific computational models have promise to improve cardiac disease diagnosis and therapy planning. Here a new method is described to simulate left-bundle branch block (LBBB) and RV-paced ventricular activation patterns in three d...
O Solovyova,L B Katsnelson,P V Konovalov et al.
O Solovyova et al.
This paper reviews the development and application of paired muscle preparations, called duplex, for the investigation of mechanisms and consequences of intra-myocardial electro-mechanical heterogeneity. We illustrate the utility of the und...
Patient-specific flexible and stretchable devices for cardiac diagnostics and therapy [0.03%]
柔性可伸缩心脏诊疗设备
Sarah R Gutbrod,Matthew S Sulkin,John A Rogers et al.
Sarah R Gutbrod et al.
Advances in material science techniques and pioneering circuit designs have led to the development of electronic membranes that can form intimate contacts with biological tissues. In this review, we present the range of geometries, sensors,...
Visualizing Cardiovascular Magnetic Resonance (CMR) imagery: challenges and opportunities [0.03%]
心血管磁共振(CMR)图像的可视化：挑战和机遇
Simon Walton,Kai Berger,Jeyarajan Thiyagalingam et al.
Simon Walton et al.
Cardiovascular Magnetic Resonance (CMR) imaging is an essential technique for measuring regional myocardial function. However, it is a time-consuming and cognitively demanding task to interpret, identify and compare various motion character...
Role of endo-epicardial dissociation of electrical activity and transmural conduction in the development of persistent atrial fibrillation [0.03%]
房室解剖结构异常在持续性心房颤动发病机制中的作用
Sander Verheule,Jens Eckstein,Dominik Linz et al.
Sander Verheule et al.
Atrial fibrillation (AF) is an arrhythmia that occurs as a result of numerous pathophysiological processes in the atria. High rate, neurohumoral activation, aging and chronic stretch activate a variety of signaling pathways leading to elect...